Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 342-348

  Karasulu, H Yeşim ^a   Şanal, Z Evren ^a   Sözer, Sumru ^a   Güneri, Tamer ^a   Ertan, Gökhan ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

Anti inflammatory activity; Indomethacin; Nasal emulsion; Penetration enhancer

Indexed keywords

CELLULOSE; CETOMACROGOL; CITRIC ACID; INDOMETACIN; NYLON; POLYSORBATE 80; PYROXYLIN; SORBITAN OLEATE; CARRAGEENAN; EMULSIFYING AGENT; HEXOSE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYSORBATE; SOYBEAN OIL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PENETRATION; IN VITRO STUDY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; NOSE MUCOSA; PAW EDEMA; RAT; ANIMAL; ARTIFICIAL MEMBRANE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; EDEMA; EMULSION; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PERMEABILITY; SHEEP; TIME; WISTAR RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CETOMACROGOL; CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; EDEMA; EMULSIFYING AGENTS; EMULSIONS; HEXOSES; INDOMETHACIN; INJECTIONS, INTRAVENOUS; MALE; MEMBRANES, ARTIFICIAL; NASAL MUCOSA; PERMEABILITY; POLYSORBATES; RATS; RATS, WISTAR; SHEEP; SOYBEAN OIL; TIME FACTORS; WATER;

EID: 51449085562     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9053-9     Document Type: Article

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