The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2

Biochemical and Biophysical Research Communications

Volumn 324, Issue 2, 2004, Pages 627-633

  Narimatsu, Shizuo ^a   Imoto, Kazuo ^a   Isobe, Takashi ^a   Kiryu, Kimio ^b   Naito, Shinsaku ^b   Hichiya, Hiroyuki ^a   Funae, Yoshihiko ^c   Hanioka, Nobumitsu ^a   Yamamoto, Shigeo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Nutrition Institutes   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bufuralol 1 hydroxylation; CYP2D1; CYP2D2; Debrisoquine 4 hydroxylation; Glycine 45: proline rich region; Leucine 43; Site directed mutagenesis

Indexed keywords

AMINO ACID; BUFURALOL; CYTOCHROME P450 2D; CYTOCHROME P450 2D1; DEBRISOQUINE; GLYCINE; LEUCINE; RECOMBINANT ENZYME; TRYPTOPHAN; VALINE;

ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HUMAN; HYDROXYLATION; MICROSOME; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPECTROSCOPY; SUBSTITUTION REACTION;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CARBON MONOXIDE; DEBRISOQUIN; DNA PRIMERS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ETHANOLAMINES; GLYCINE; KINETICS; LEUCINE; LIVER; MICROSOMES; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; PROLINE; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY; VALINE;

EID: 5144229686     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.089     Document Type: Article

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