Enzymatic formation of an unnatural novel tetracyclic sesterterpene by β-amyrin synthase

Tetrahedron Letters

Volumn 45, Issue 45, 2004, Pages 8299-8301

  Noma, Hisashi ^a   Tanaka, Hideya ^a   Noguchi, Hiroshi ^a   Shibuya, Masaaki ^b   Ebizuka, Yutaka ^b   Abe, Ikuro ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Amyrin synthase; Oxidosqualene cyclase; Triterpene synthase; Unnatural sesterterpene

Indexed keywords

BETA AMYRIN; SESTERTERPENE;

ANALYTIC METHOD; ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; ENZYME CHEMISTRY; REACTION ANALYSIS; SYNTHESIS;

PISUM; PISUM SATIVUM;

EID: 5144223773     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.09.075     Document Type: Article

References (11)

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3. R. Xu, G.C. Fazio, and S.P.T. Matsuda Phytochemistry 65 2004 261 291
4. I. Abe, Y. Sakano, H. Tanaka, W. Lou, H. Noguchi, M. Shibuya, and Y. Ebizuka J. Am. Chem. Soc. 126 2004 3462 3463
5. I. Abe, Y. Sakano, M. Sodeyama, H. Tanaka, H. Noguchi, M. Shibuya, and Y. Ebizuka J. Am. Chem. Soc. 126 2004 6880 6881
6. Q. Xiong, X. Zhu, W.K. Wilson, A. Ganesan, and S.P.T. Matsuda J. Am. Chem. Soc. 125 2003 9002 9003
7. I. Abe, H. Tanaka, and H. Noguchi J. Am. Chem. Soc. 124 2002 14514 14515
8. 42O] 358.3240; calcd 358.3236
9. 58O] 494.4472; calcd 494.4488
10. 3CN; 0.3 mL/min) to give 0.3 mg of compound 7, along with 3.5 mg of β-amyrin derived from 2,3-oxidosqualene accumulated in the mutant yeast cells
11. 42O] 358.3241; calcd 358.3236