A double-dummy, double-blind, placebo-controlled phase III study comparing the efficacy and efficiency of miconazole chewing gum with a known drug (Brentan® gel) and a placebo in patients with oral candidosis

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 98, Issue 4, 2004, Pages 423-428

  Bastian, Henning Lehmann ^a   Rindum, Judith ^b   Lindeberg, Henning ^c  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MICONAZOLE;

ADULT; ARTICLE; CHEWING GUM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EVALUATION; FUNGUS CULTURE; HUMAN; HUMAN TISSUE; HYPOTHESIS; MAJOR CLINICAL STUDY; PHASE 3 CLINICAL TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; THRUSH;

EID: 5144223358     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2003.12.028     Document Type: Article

References (13)

1. Odds F.C. Candida and candidosis. 2nd ed.:1988;Bailliere Tindall, London
2. Lamey P.J., Samaranayake L.P. Oral candidosis: 2. Diagnosis and management. Dent Update. 15:1988;328-331
3. Pedersen M. Tyggegummi som lægemiddelform. 1990; Licentiatafhandling, København
4. Peeters J. Determination of ionization constants in mixed aqueous solvents of varying composition by a single titration. J Pharm Sci. 127:1978;67
5. Pedersen M., Rassing M.R. Miconazole chewing gum as a drug delivery system test of release promoting additives. Drug Dev Ind Pharm. 17:1991;411-420
6. Rindum J.R., Holmstrup P., Pedersen M., Rassing M.R., Stoltze K. Miconazole chewing gum for treatment of chronic oral candidosis. Scand J Dent Res. 6:1993;386-390
7. Holmstrup P., Axéll T. Classification and clinical manifestations of oral yeast infections. Acta Odontol Scand. 48:1990;57-59
8. Arendorf T.M., Walker D.M. Oral candidal populations in health and disease. Brit Dent J. 147:1979;267-272
9. Arendorf T.M., Walker D.M. The prevalence and intraoral distribution of Candida albicans in man. Arch Oral Biol. 25:1980;1-10
10. Kreger-van Rij. The yeasts: a taxonomic study. 3rd ed.:1984;Elsevier, Amsterdam
11. Haley L.D., Callaway C.S. Laboratory methods in medical mycology. 1978;US Centers for Disease Control, Atlanta
12. Hochberg Y., Tamhane A.C. Multiple comparison procedures. 1997;Wiley, New York. p. 91-3
13. Hollander M., Wolfe D.A. Nonparametic statistic of methods. 1973;Wiley, New York. p. 75-8