Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome

Fertility and Sterility

Volumn 82, Issue 4, 2004, Pages 973-975

  Kahsar Miller, Melissa ^a,b   Boots, Larry R ^a   Bartolucci, Alfred ^a   Azziz, Ricardo ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CYTOCHROME P450 17; CYTOSINE; STERYL SULFATASE; THYMINE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC CODE; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL;

ADOLESCENT; ADRENAL GLANDS; ADULT; ALLELES; ANDROGENS; DEHYDROEPIANDROSTERONE SULFATE; DNA; FEMALE; HUMANS; MIDDLE AGED; POLYCYSTIC OVARY SYNDROME; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SOUTHEASTERN UNITED STATES; STEROID 17-ALPHA-HYDROXYLASE; TESTOSTERONE;

EID: 5144219562     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2004.05.068     Document Type: Article

References (28)

1. E.S. Knochenhauer, T.J. Key, M. Kahsar-Miller, W. Waggoner, L.R. Boots, R. Azziz Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study J Clin Endocrinol Metab 83 1998 3078 3082
2. E. Diamanti-Kandarakis, C.R. Kouli, A.T. Bergiele, F.A. Filandra, T.C. Tsianateli, G.G Spina A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile J Clin Endocrinol Metab 84 1999 4006 4011
3. M. Asuncion, R.M. Calvo, J.L. San Millan, J. Sancho, S. Avila, H.F. Escobar-Morreale A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain J Clin Endocrinol Metab A85 2000 2434 2438
4. J.K. Zawadzki, A. Dunaif Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif J.R. Givens F. Haseltine G.R. Merriam Polycystic ovary syndrome 1990 Blackwell Scientific Publications Boston 377 384
5. C. Moran, E.S. Knochenhauer, L.R. Boots, R. Azziz Adrenal androgen excess in hyperandrogenism: relation to age and body mass Fertil Steril 71 1999 671 674
6. L. Ibanez, N. Potau, R. Virdis, M. Zampolli, C. Terzi, M Gussinye Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism J Clin Endocrinol Metab 76 1993 1599 1603
7. L. Lazar, R. Kauli, C. Bruchis, J. Nordenberg, A. Galatzer, A. Pertzelan Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response Eur J Endocrinol 133 1993 403 406
8. R. Azziz, S.M. Slayden Mechanisms of steroid excess in 21-hydroxylase deficient non-classic adrenal hyperplasia J Soc Gynecol Invest 3 1996 297 302
9. Y. Akamine, K. Kato, H. Ibayashi Studies on changes in the concentration of serum adrenal androgens in pubertal twins Acta Endocrinologica 93 1980 356 364
10. J.I. Rotter, F.L. Wong, E.T. Lifrak, L.N. Parker A genetic component to the variation of dehydroepiandrosterone sulfate Metabolism 34 1995 731 736
11. A.W. Meikle, J.D. Stringham, M.G. Woodward, D.T. Bishop Heritability of variation of plasma cortisol levels Metabolism 37 1988 514 517
12. T. Rice, D.L. Sprecher, I.B. Borecki, L.E. Mitchell, P.M. Laskarzewski, D.C. Rao The Cincinnati Myocardial Infarction and Hormone Family Study: family resemblance for dehydroepiandrosterone sulfate in control and myocardial infarction families Metabolism 42 1993 1284 1290
13. J. Picado-Leonard, W.L. Miller Cloning and sequence of the human gene for P450c17 (steroid 17-hydroxylase/17,20 lyase): similarity with the gene for p450c21 DNA (NY) 6 1987 439 448
14. W.L. Miller Androgen biosynthesis from cholesterol to DHEA Mol Cell Endocrinol 198 2002 7 14
15. A.H. Carey, D. Waterworth, K. Patel, D. White, J. Little, P Novelli Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17 Hum Mol Gen 3 1994 1873 1876
16. J.T. Kadonaga, K.A. Jones, R. Tjian Promoter-specific activation of RNA polymerase II transcription by Sp1 Trends Biochem Sci 3 1986 20 23
17. J.M. Zmuda, J.A. Cauley, L.H. Kuller, R.E. Ferrell A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men J Bone Miner Res 16 2001 911 917
18. J. Somner, S. McLellan, J. Cheung, Y.T. Mak, M.L. Frost, K.M Knapp Polymorphisms in the P450 C17 (17-Hydroxylase/17,20-Lyase) and P450 C19 (Aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women J Clin Endocrinol Metab 89 2004 344 351
19. N.E. Allen, M.S. Forrest, T.J. Key The association between polymorphisms in the CYP17 and 5alpha-reductase (SRD5A2) genes and serum androgen concentrations in men Cancer Epidemiol Biomarkers Prev 10 2001 185 189
20. C.A. Haiman, M.J. Stampfer, E. Giovannucci, J. Ma, N.E. Decalo, P.W Kantoff The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer Cancer Epidemiol Biomarkers Prev 10 2001 743 748
21. R.M. Lunn, D.A. Bell, J.L. Mohler, J.A. Taylor Prostate cancer risk and polymorphism in 17-hydroxylase (CYP17) and steroid reductase (SRD5A2) Carcinogenesis 20 1999 1727 1731
22. A. Gsur, G. Bernhofer, S. Hinteregger, G. Haidinger, G. Schatzl, S Madersbacher A polymorphism in the CYP17 gene is associated with prostate cancer risk Int J Cancer 87 2000 434 437
23. J.L. Stanford, E.A. Noonan, L. Iwasaki, S. Kolb, R.B. Chadwick, Z Feng A polymorphism in the CYP17 gene and risk of prostate cancer Cancer Epidemiol Biomarkers Prev 11 2002 243 247
24. R.A. Kittles, R.K. Panguluri, W. Chen, A. Massac, C. Ahaghotu, A Jackson CYP17 promoter variant associated with prostate cancer aggressiveness in African Americans Cancer Epidemiol Biomarkers Prev 10 2001 943 947
25. B. Chang, S.L. Zheng, S.D. Isaacs, K.E. Wiley, J.D. Carpten, G.A Hawkins Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer Int J Cancer 95 2001 354 359
26. Y. Yamada, M. Watanabe, M. Murata, M. Yamanaka, Y. Kubota, H Ito Impact of genetic polymorphisms of 17-hydroxylase cytochrome P-450 (CYP17) and steroid 5alpha-reductase type II (SRD5A2) genes on prostate-cancer risk among the Japanese population Int J Cancer 92 2001 683 686
27. H.S. Feigelson, G.A. Coetzee, L.N. Kolonel, R.K. Ross, B.E. Henderson A polymorphism in the CYP17 gene increases the risk of breast cancer Cancer Res 57 1997 1063 1065
28. C.S. Huang, H.D. Chern, K.J. Chang, C.W. Cheng, S.M. Hsu, C.Y. Shen Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility Cancer Res 59 1999 4870 4875