Structure-activity relationships of estrogen derivatives as aromatase inhibitors. Effects of heterocyclic substituents

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 9, 2008, Pages 1304-1309

  Numazawa, Mitsuteru ^a   Komatsu, Sachiko ^a   Tominaga, Takako ^a   Yamashita, Kouwa ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Aromatase; Competitive inhibitor; Estradiol derivative; Estrone derivative; Inhibition activity; Isonicotinyl derivative

Indexed keywords

2 AMINO 3 BENZYLOXYESTRA 1,3,5 TRIEN 17 ONE; 2 NITRO 3 BENZYLOXYESTRA 1,3,5 TRIEN 17 ONE; 3 BENZYLOXYESTRA 1,3,5 TRIEN 17 ONE DERIVATIVE; 3 TERT BUTYLDIMETHYLSILOXY 17BETA ESTRADIOL DERIVATIVE; 4 AMINO 3 BENZYLOXYESTRA 1,3,5 TRIEN 17 ONE; 4 NITRO 3 BENZYLOXYESTRA 1,3,5 TRIEN 17 ONE; ANDROSTENEDIONE; AROMATASE INHIBITOR; ESTRA 1,3,5 TRIEN 17 ONE; ESTRADIOL DERIVATIVE; ESTROGEN DERIVATIVE; ESTRONE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG ACTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AROMATASE INHIBITORS; CHEMISTRY, PHYSICAL; ESTRADIOL; ESTRONE; FEMALE; HETEROCYCLIC COMPOUNDS; HUMANS; INDICATORS AND REAGENTS; KINETICS; MASS SPECTROMETRY; MICROSOMES; PLACENTA; PREGNANCY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51349140489     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1304     Document Type: Article

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