Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery

Acta Pharmacologica Sinica

Volumn 29, Issue 9, 2008, Pages 1021-1028

  Cui, Li Jun ^a   Sun, Nai Xue ^a   Li, Xing Hua ^a   Huang, Jie ^a   Yang, Jian Gang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

5 fluorouracil; Glaucoma; Intraocular pressure; Microsphere; Polymer; Rabbit; Sustained release

Indexed keywords

FLUOROURACIL; MICROSPHERE; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BIOMICROSCOPY; CONCENTRATION (PARAMETERS); CONJUNCTIVAL BIOPSY; CONTROLLED STUDY; CORNEA ENDOTHELIUM; CORNEA INJURY; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEMALE; FILTERING FISTULA; FISTULA; GLAUCOMA; GLAUCOMA DRAINAGE IMPLANT; HYPEREMIA; INFLAMMATION; INTRAOCULAR PRESSURE; MALE; NONHUMAN; POSTOPERATIVE PERIOD; QUANTITATIVE ANALYSIS; RABBIT; SUSTAINED DRUG RELEASE; TRABECULECTOMY;

ANIMALS; ANTIMETABOLITES; AQUEOUS HUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONJUNCTIVA; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; FLUOROURACIL; GLAUCOMA DRAINAGE IMPLANTS; INDICATORS AND REAGENTS; INTRAOCULAR PRESSURE; LACTIC ACID; MICROSPHERES; OPHTHALMOLOGIC SURGICAL PROCEDURES; PARTICLE SIZE; POLYGLYCOLIC ACID; PROSTHESIS IMPLANTATION; RABBITS; SPECTROPHOTOMETRY, ULTRAVIOLET; SURVIVAL ANALYSIS;

EID: 51349137951     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00833.x     Document Type: Article

References (26)

1. Collignon NJ. Wound healing after glaucoma surgery: how to manage it Bull Soc Beige Ophtalmol 2005 295 : 55 9.
2. Lama PJ, Fechtner RD. Antifibrotics and wound healing in glaucoma surgery. Surv Ophthalmol 2003 48 : 314 46.
3. Tahery MM, Lee DA. Pharmacologic control of wound healing in glaucoma nitration surgery. J Ocul Pharmacol 1989 5 : 155 79.
4. The Fluorouracil Filtering Surgery Study Group. Five-year follow-up of the fluorouracil filtering surgery study. Am J Ophthalmol 1996 121 : 349 66.
5. Joshi AB, Parrish RK 2nd., Feuer WF. 2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. J Glaucoma 2005 14 : 172 4.
6. Abraham LM, Selva D, Casson R, Leibovitch I. The clinical applications of fluorouracil in ophthalmic practice. Drugs 2007 67 : 237 55.
7. Sisto D, Vetrugno M, Trabucco T, Cantatore F, Ruggeri G, Sborgia C. The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate-term follow-up. Acta Ophthalmol Scand 2007 85 : 267 71.
8. Fraser S. Trabeculectomy and antimetabolites. Br J Ophthalmol 2004 88 : 855 6.
9. Elorza B, Elorza MA, Frutos G, Chantres JR. Characterization of 5-fluorouracil loaded liposomes prepared by reverse-phase evaporation or freezing-thawing extrusion methods: study of drug release. Biochim Biophys Acta 1993 1153 : 135 42.
10. Hitzman CJ, Elmquist WF, Wattenberg LW, Wiedmann TS. Development of a respirable, sustained release microcarrier for 5-fluorouracil I: In vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. J Pharm Sci 2006 95 : 1114 26.
11. Aksungur P, Sungur A, Unal S, Iskit AB, Squier CA, Senel S. Chito-san delivery systems for the treatment of oral mucositis: in vitro and in vivo studies. J Control Release 2004 98 : 269 79.
12. Gao H, Gu Y, Ping Q. The implantable 5-fluorouracil-loaded poly(l-lactic acid) fibers prepared by wet-spinning from suspension. J Control Release 2007 118 : 325 32.
13. Pandey SK, Cochener B, Apple DJ, Colin J, Werner L, Bougaran R, et al. Intracapsular ring sustained 5-fluorouracil delivery system for the prevention of posterior capsule opacification in rabbits: a histo-logical study. J Cataract Refract Surg 2002 28 : 139 48.
14. Sastre RL, Olmo R, Teijón C, Muñiz E, Teijón JM, Blanco MD. 5-Fluorouracil plasma levels and biodegradation of subcutane-ously injected drug-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers. Int J Pharm 2007 338 : 180 90.
15. Moritera T, Ogura Y, Honda Y, Wada R, Hyon SH, Ikada Y. Micro-spheres of biodegradable polymers as a drug-delivery system in the vitreous. Invest Ophthalmol Vis Sci 1991 32 : 1785 90.
16. Huang KH, Zhu ZH, Liu JH, Chen QK, Liu XY, Chang J. Preparation and release efficiency of polylactic acid nanoparticle. Ai Zheng 2005 24 : 1023 6.
17. Blandford DL, Smith TJ, Brown JD, Pearson PA, Ashton P. Subcon-junctival sustained release 5-fluorouracil. Invest Ophthalmol Vis Sci 1992 33 : 3430 5.
18. Lee DA, Leong KW, Panek WC, Eng CT, Glasgow BJ. The use of bioerodible polymer and 5-fluorouracil in glaucoma filtering surgery. Invest Ophthalmol Vis Sci 1988 29 : 1692 7.
19. Einmahl S, Behar-Cohen F, D'Hermies F, Rudaz S, Tabatabay C, Re-nard G, et al. A new poly(ortho ester)-based drug delivery system as an adjunct treatment in filtering surgery. Invest Ophthalmol Vis Sci 2001 42 : 695 700.
20. Heller J. Ocular delivery using poly(ortho esters). Adv Drug Deliv Rev 2005 57 : 2053 62.
21. Jampel HD, Leong KW, Dunkelburger GR, Quigley HA. Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride discs. Arch Ophthalmol 1990 108 : 430 5.
22. Hasty B, Heuer DK, Minckler DS. Primate trabeculectomies with 5-fluorouracil collagen implants. Am J Ophthalmol 1990 109 : 721 5.
23. Lee DA, Shapourifar TS, Kitada S. The effect of 5-fluorouracil and cytarabine on human fibroblasts from Tenon's capsule. Invest Ophthalmol Vis Sci 1990 31 : 1848 55.
24. Khaw PT, Word S, Porter A, Grierson I, Hitchings RA, Rice NSC. The long-term effects of 5-fluorourocil and sodium butyrate on human tenon's fibroblasts. Invest Ophthalmol Vis Sci 1992 33 : 2043 52.
25. Mannis MJ, Sweet EH, Lewis RA. The effect of fluorouracil on the corneal endothelium. Arch Ophthalmol 1988 106 : 816 7.
26. Wilkins MR, Occleston NL, Kotecha A, Waters L, Khaw PT. Sponge delivery variables and tissue levels of 5-fluorouracil. Br J Ophthalmol 2000 84 : 92 7.