Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality

PLoS ONE

Volumn 2, Issue 3, 2007, Pages

  Fredriksson, Jenny ^a   Anevski, Dragi ^a,b   Almgren, Peter ^a   Sjögren, Marketa ^a   Lyssenko, Valeriya ^a   Carlson, Joyce ^a   Isomaa, Bo ^c   Taskinen, Marja Riitta ^d   Groop, Leif ^a,d,e   Orho Melander, Marju ^a  

^a LUND UNIVERSITY   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c FOLKHÄLSAN RESEARCH CENTER   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; GLYCOGEN SYNTHASE;

ADULT; ALLELE; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; EXERCISE; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; HYPERTENSION; IMMOBILIZATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PREDICTION; RISK FACTOR; SEX DIFFERENCE; SMOKING HABIT; AGED; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETICS; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHYSIOLOGY; PREDICTION AND FORECASTING; SEXUAL DEVELOPMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; APOLIPOPROTEINS E; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; GENETIC VARIATION; GLYCOGEN SYNTHASE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SEX CHARACTERISTICS;

EID: 51349129447     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000285     Document Type: Article

References (44)

1. Bethesda (2002) National Heart, Lung and Blood Institute. NHLBI morbidity and mortality chartbook. www.nhlbi.nih.gov/resources/docs/ cht-book.htm.
2. (1999) Summary of the second report of the National Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult treatment panel II). JAMA 269: 3015-3023.
3. Rinn JL, Snyder M (2005) Sexual dimorphism in mammalian gene expression. Trends Genet 21: 298-305.
4. Groop LC, Kankuri M, Schalin Jantti C, Ekstrand A, Nikula Ijas P, et al. (1993) Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 328: 10-14.
5. Zouali H, Velho G, Froguel P (1993) Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 328: 1568.
6. Schalin-Jäntti C, Harkonen M, Groop LC (1995) Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 41: 598-604.
7. Orho-Melander M, Almgren P, Kanninen T, Forsblom C, Groop LC (1999) A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene. Diabetologia 42: 1138-1145.
8. Fenger M, Poulsen P, Beck-Nielsen H, Vaag A (2000) Impact of the XbaI-polymorphism of the human muscle glycogen synthase gene on parameters of the insulin resistance syndrome in a Danish twin population. Diabet Med 17: 735-740.
9. Kadowaki T, Kadowaki H, Yazaki Y (1993) Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 328: 1568-1569.
10. Rissanen J, Pihlajamaki J, Heikkinen S, Kekalainen P, Mykkanen L, et al. (1997) New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland. Diabetologia 40: 1313-1319.
11. St-Onge J, Joanisse DR, Simoneau JA (2001) The stimulation-induced increase in skeletal muscle glycogen synthase content is impaired in carriers of the glycogen synthase XbaI gene polymorphism. Diabetes 50: 195-198.
12. Pratley RE, Thompson DB, Prochazka M, Baier L, Mott D, et al. (1998) An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 101: 1757-1764.
13. Watanabe RM, Ghosh S, Langefeld CD, Valle TT, Hauser ER, et al. (2000) The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet 67: 1186-1200.
14. Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, et al. (2002) Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 51: 1247-1255.
15. Panhuysen CI, Cupples LA, Wilson PW, Herbert AG, Myers RH, et al. (2003) A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia 46: 579-587.
16. van Tilburg JH, Sandkuijl LA, Strengman E, van Someren H, Rigters-Aris CA, et al. (2003) A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13. J Clin Endocrinol Metab 88: 2223-2230.
17. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, et al. (2005) Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54: 909-914.
18. An P, Teran-Garcia M, Rice T, Rankinen T, Weisnagel SJ, et al. (2005) Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study. Diabetologia 48: 1142-1149.
19. Mahley R (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240: 622-630.
20. Sing CF DJ (1985) Role of apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 37: 268-285.
21. Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Uterman G (1986) Apolipoprotein E polymorphisms in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 27: 227-235.
22. Wilson PW, Schaefer EJ, Larson MG, Ordovas JM (1996) Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler Thromb Vasc Biol 16: 1250-1255.
23. Song Y, Stampfer MJ, Liu S (2004) Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med 141: 137-147.
24. Artiga MJ, Bullido MJ, Sastre I, Recuero M, Garcia MA, et al. (1998) Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett 421: 105-108.
25. Ye S, Dunleavey L, Bannister W, Day LB, Tapper W, et al. (2003) Independent effects of the -219 G>T and epsilon 2/epsilon 3/epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study. Eur J Hum Genet 11: 437-443.
26. Lambert JC, Brousseau T, Defosse V, Evans A, Arveiler D, et al. (2000) Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study. Hum Mol Genet 9: 57-61.
27. Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, et al. (1996) Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 45: 1585-1593.
28. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, et al. (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24: 683-689.
29. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation [see comments]. Diabet Med 15: 539-553.
30. Schalin-Jantti C, Nikula-Ijas P, Huang X, Lehto M, Knudsen P, et al. (1996) Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects. Hypertension 27: 67-71.
31. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
32. Casella G, Berger, R L (1990) Statistical Inference: Duxbury press; 360.
33. Ober C, Abney M, McPeek MS (2001) The genetic dissection of complex traits in a founder population. Am J Hum Genet 69: 1068-1079.
34. Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, et al. (2003) Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population. Eur J Hum Genet 11: 845-850.
35. Bosse Y, Chagnon YC, Despres JP, Rice T, Rao DC, et al. (2004) Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study. J Lipid Res 45: 419-426.
36. Adeyemo AA, Johnson T, Acheampong J, Oli J, Okafor G, et al. (2005) A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population. Atherosclerosis 181: 389-397.
37. Heijmans BT, Beekman M, Putter H, Lakenberg N, van der Wijk HJ, et al. (2005) Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Eur J Hum Genet 13: 1143-1153.
38. Pollin TI, Hsueh WC, Steinle NI, Snitker S, Shuldiner AR, Mitchell BD (2004) A genome-wide scan of serum lipid levels in the Old Order Amish. Atherosclerosis 173: 89-96.
39. Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, et al. (2004) Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Diabetes 53: 1857-1865.
40. Feitosa MF, Rice T, North KE, Kraja A, Rankinen T, et al. (2005) Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE family study. Atherosclerosis.
41. Weiss LA, Pan L, Abney M, Ober C (2006) The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 38: 218-222.
42. Shephard RJ (2000) Exercise and training in women, Part I: Influence of gender on exercise and training responses. Can J Appl Physiol 25: 19-34.
43. Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, et al. (2001) Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 88: 1020-1027.
44. Dupont W, Plummer Jr W. PS: Power and Sample Size Calculation.