The effect of Korean red ginseng extract on the relaxation response in isolated rabbit vaginal tissue and its mechanism

Journal of Sexual Medicine

Volumn 5, Issue 9, 2008, Pages 2079-2084

  Kim, Sun Ouck ^a   Kim, Min Kyung ^a   Lee, Hyun Suk ^a   Park, Jong Kwan ^b   Park, Kwangsung ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Korean Red Ginseng; Rabbit; Vagina

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL; GINSENG EXTRACT; GLIBENCLAMIDE; GUANYLATE CYCLASE; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG MECHANISM; FEMALE; FEMALE SEXUAL DYSFUNCTION; GINSENG; HERBAL MEDICINE; HYPERPOLARIZATION; INHIBITION KINETICS; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE; SMOOTH MUSCLE RELAXATION; VAGINA;

EID: 51349121210     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.00946.x     Document Type: Article

References (21)

1. Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr 1986;55:643-9.
2. Chong SK, Oberholzer VG. Ginseng - Is there a use in clinical medicine? Postgrad Med J 1988;64:841-6.
3. Kang SY, Kim ND. The antihypertensive effect of red ginseng saponin and the endothelium-derived vascular relaxation. Korean J Ginseng Sci 1992;16:175-82.
4. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50.
5. Munarriz R, Kim SW, Kim NN, Traish A, Goldstein I. A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model. J Urol 2003;170:S40-4.
6. Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi K. Vasculogenic female sexual dysfunction: The hemodynamic basis of vaginal engorgement insufficiency and clitoral insufficiency. Int J Impot Res 1997;9:27-37.
7. Giraldi A, Marson L, Nappi R, Pfaus J, Traish AM, Vardi Y, Goldstein I. Physiology of female sexual function: Animal models. J Sex Med 2004;1:237-53.
8. Shabsigh A, Buttyan R, Burchardt T, Buchardt M, Hayek OR, D'Agati V, Olsson C, Shabsigh R. The microvascular architecture of the rat vagina revealed by image analysis of vascular corrosion casts. Int J Impot Res 1999;11:S23-30.
9. Berman JR, Adhikari SP, Goldstein I. Anatomy and physiology of female sexual function and dys function: Classification, evaluation and treatment options. Eur Urol 2000;38:20-9.
10. Gillis CN. Panax ginseng pharmacology: A nitric oxide link. Biochem Pharmacol 1997;54:1-8.
11. Chen X. Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol 1996;23:728-32.
12. Tamaoki J, Nakata J, Kawatani K, Tagaya E, Nagai A. Ginsenoside-induced relaxation of human bronchial smooth muscle via release of nitric oxide. Br J Pharmacol 2000;130:1859-64.
13. Ahn TY, Kim Sk, Kim CS, Park TH, Park HS. The effect of ginseng on the relaxation of the penile corpus cavernosal smooth muscle in rabbits. Korean J Ginseng Sci 1996;20:339-43.
14. Park K, Kim GS, Kim SO, Kim DS, Kim MK, Park JK, Nah SY, Kim KK. Effects of ginsenosides on relaxation of rabbit vaginal smooth muscle. Korean J Androl 2003;21:98-102.
15. ++ channels in vascular smooth muscle. Acta Pharmacol Sin 1994;15:392-8.
16. + channels in ginsenosides-induced aortic relaxation in rats. J Cardiovasc Pharmarcol 2001;37:41-7.
17. Choi YD, Xin ZC, Choi HK. Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res 1998;10:37-43.
18. Chen X, Lee TJ. Gisenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115:15-8.
19. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest 1991;88:112-8.
20. Ziessen T, Moncada S, Cellek S. Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol 2002;135:546-54.
21. Azadzoi KM, Tarcan T, Siroky MB, Krane RJ, Goldstein I. Characterization of clitoral cavernosal and vaginal smooth muscle contractility in the rabbit. Int J Impot Res 1998;10(suppl):S58.