Theoretical model of thalassemic erythrocyte shape transformation

Journal of Theoretical Biology

Volumn 254, Issue 3, 2008, Pages 575-579

  Pawlowski, Piotr H ^a   Burzyńska, Beata ^a   Zielenkiewicz, Piotr ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

Erythrocyte; Erythropoiesis; Reticulocyte; Thalassemia; Theoretical model

Indexed keywords

BLOOD; COMPARATIVE STUDY; METAMORPHOSIS; SIMULATION;

ARTICLE; CELL STRUCTURE; CELL VOLUME; ERYTHROCYTE SHAPE; PRIORITY JOURNAL; SIMULATION; SPLENECTOMY; THALASSEMIA;

CELL SHAPE; COMPUTER SIMULATION; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; ERYTHROPOIESIS; HUMANS; MODELS, BIOLOGICAL; RETICULOCYTES; THALASSEMIA;

EID: 51349119525     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2008.06.029     Document Type: Article

References (17)

1. Bianco I., Cappabianca M.P., Foglietta E., Lerone M., Deidda G., Morlupi L., Grisanti P., Ponzini D., Rinaldi S., and Graziani B. Silent thalassemias genotypem and phenotypes. Haematologica 82 (1997) 269-280
2. Clark B.E., and Tein S.L. Molecular diagnosis of haemoglobin disorders. Clin. Lab. Haematol. 26 (2004) 159-176
3. Evans E.A., Waugh R., and Melnik L. Elastic area compressibility modulus of red cell membrane. Biophys. J. 16 (1976) 585-595
4. Kuypers F.A., Schott M.A., and Scott M.D. Phospholipid composition and organization in model β-thalassemic erythrocytes. Am. J. Hematol. 51 (1996) 45-54
5. Mohandas N., Chasis J.A., and Shohet S.B. The influence of membrane skeleton on red cell deformability, membrane material properties, and shape. Semin. Hematol. 20 (1983) 225-242
6. Pawlowski P.H., Burzynska B., and Zielenkiewicz P. Theoretical model of reticulocyte to erythrocyte shape transformation. J. Theor. Biol. 243 (2006) 24-38
7. Rachmilewitz E.A., Shohet S.B., and Lubin B.H. Lipid membrane peroxidation in beta-thalassemia major. Blood 47 (1976) 495-505
8. Rouyer-Fessard P., Garel M.C., Domenget C., Guetarni D., Bachir D., Colonna P., and Beuzard Y. A study of membrane protein defects and alpha hemoglobin chains of red blood cells in human beta thalassemia. J. Biol. Chem. 264 (1989) 19092-19098
9. Sanghani S.P., Haldankar V.A., Shalia K.K., and Bichile S.K. Comparative analysis of RBC membrane lipids in thalassemia and iron deficiency anemia in relation to hypochromia and oxidant injury. Indian J. Clin. Biochem. 16 (2001) 116-121
10. Schrier S.L. Pathobiology of thalassemic erythrocytes. Curr. Opin. Hematol. 4 (1997) 75-78
11. Schrier, S.L., 2006. Pathophysiology of the thalassaemias. In: Disorders of iron homeostasis, erythrocytes, erythropoesis. European School of haematology, pp. 229-235.
12. Schrier S.L., Rachmilewitz E., and Mohandas N. Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations. Blood 74 (1989) 2194-2202
13. Shinar E., Shalev O., Rachmilewitz E.A., and Schrier S.L. Erythrocyte membrane skeleton abnormalities in severe beta-thalassemia. Blood 70 (1987) 158-164
14. Shinar E., Rachmilewitz E.A., and Lux S.E. Differing Erythrocyte membrane skeletal protein defects in alpha end beta thalassemie. J. Clin. Invest. 83 (1989) 404-410
15. Tillman W., and Schröter W. Rheological properties of erythrocytes in heterozygous and homozygous β thalassaemia. Br. J. Hematol. 43 (1979) 401-411
16. Weatherall D.J. Thalassaemia: the long road from bedside to genome. Nat. Rev. Genet. 5 (2004) 625-631
17. Weatherall D.J., and Clegg J.B. The Thalassaemia Syndromes. fourth ed (2001), Blackwell Science, Oxford