Gender role across development in adults with 46,XY disorders of sex development including perineoscrotal hypospadias and small phallus raised male or female

Journal of Pediatric Endocrinology and Metabolism

Volumn 21, Issue 7, 2008, Pages 625-630

  Pappas, Kara B ^a   Wisniewski, Amy B ^b   Migeon, Claude J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Ambiguous genitalia; Disorders of sex differentiation; Intersex; Psychosexual

Indexed keywords

ADULT; ANDROGEN INSENSITIVITY SYNDROME; ARTICLE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMININITY; FEMINIZATION; FOLLOW UP; GONADAL DYSGENESIS; HUMAN; HYPOSPADIAS; KARYOTYPE 46,XY; LEARNING; MALE; MASCULINITY; PENIS DISEASE; PSYCHOSEXUAL DEVELOPMENT; QUESTIONNAIRE; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SELF CONCEPT; SEX DIFFERENTIATION DISORDER; SEX ROLE; SEXUAL DEVELOPMENT; SOCIALIZATION; VIRILIZATION;

EID: 51349118154     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2008.21.7.625     Document Type: Article

References (19)

1. Hines M. Androgen and psychosexual development: core gender identity, sexual orientation, and recalled childhood gender role behavior in women and men with congenital adrenal hyperplasia (CAH). J Sex Res 2004; 41: 75-81.
2. Money J, Ehrhardt AA. Man and Woman, Boy and Girl: The Differentiation and Dimorphism of Gender Identity from Conception to Maturity. Baltimore, MD: Johns Hopkins Press, 1972.
3. Meaney MJ, McEwen BS. Testosterone implants into the amygdala during the neonatal period masculinize the social play of juvenile female rats. Brain Res 1986; 398: 324-328.
4. Goy RW, Bercovitch FB, McBrair MC. Behavioral masculinization is independent of genital masculinization in prenatally androgenized female rhesus macaques. Horm Behav 1988; 22: 552-571.
5. Berenbaum SA, Snyder E. Early hormonal influences on childhood sex-typed activity and playmate preferences: implications for the development of sexual orientation. Dev Psychol 1995; 31: 31-42.
6. Berenbaum SA, Hines M. Early androgens are related to childhood sex-typed toy preferences. Psychol Sci 1992; 3: 203-206.
7. Berenbaum SA. Effects of early androgens on sex-typed activities and interests in adolescents with congenital adrenal hyperplasia. Horm Behav 1999; 35: 102-110.
8. Ehrhardt AA, Baker SW. Fetal androgens, human central nervous system differentiation, and behavior sex differences. In: Friedman RC, Richart RR, Van de Wiele RL, eds. Sex Differences in Behavior. Chichester-New York: Wiley, 1974; 33-51.
9. Dittman RW, Kappes ME, Borger D, Stegner H, Willig RH, Wallis H. Congenital adrenal hyperplasia: gender-related behaviors and attitudes in female patients and their sisters. Psychoneuroendocrinology 1990; 15: 401-420.
10. Mulaikal RM, Migeon CJ, Rock JA. Fertility rates in female patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. N Engl J Med 1987; 316: 178-182.
11. Meyer-Bahlburg HFL, Dolezal C, Baker SW, Ehrhardt AA, New MI. Gender development in women with congenital adrenal hyperplasia as a function of disorder severity. Arch Sex Behav 2006; 35: 667-684.
12. Nordenstrom A, Servin A, Bohlin G, Larsson A, Wedell A. Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia. J Clin Endocrin Metab 2002; 87: 5119-5124.
13. Long DN, Wisniewski AB, Migeon CJ. Gender role across development in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Pediatr Endocrinol Metab 1994; 17: 1367-1373.
14. Quigley CA, de Bellis A, Marschke KB, El-Awady MK, Wilson EM, French FS. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev 1995; 16: 271-321.
15. Mendonca BB, Inacio M, Costa EMF, Arnhold IJP, Silva FAQ, Nicolau W, Bloise W, Russell DW, Wilson JD. Male pseudohermaphroditism due to steroid 5 alpha-reductase 2 deficiency: diagnosis, psychological evaluation and management. Medicine 1996; 75: 64-76.
16. Mendonca BB, Inacio M, Arnhold IJP, Costa EMF, Bloise W, Martin RM, Denes FT, Silva FAQ, Andersson S, Lindqvist A, Wilson JD. Male pseudohermaphroditism due to 12β-hydroxysteroid dehydrogenase 3 deficiency: diagnosis, psychological evaluation, and management. Medicine 2000; 79: 299-309.
17. Migeon CJ, Wisniewski AB, Gearhart JP, Meyer-Bahlburg HFL, Rock JA, Brown TR, Casella SJ, Maret A, Ngai KM, Money J, Berkovitz GD. Ambiguous genitalia with perineoscrotal hypospadias in 46,XY individuals: long-term medical, surgical, and psycho-sexual outcome. Pediatrics 2002; 110: e31.
18. Mazur T. Gender dysphoria and gender change in androgen insensitivity or micropenis. Arch Sex Behav 2005; 34: 411-421.
19. Hines M. Prenatal testosterone and gender-related behaviour. Eur J Endocrinol 2006; 155: S115-S121.