Structural basis for group A trichothiodystrophy

Nature Structural and Molecular Biology

Volumn 15, Issue 9, 2008, Pages 980-984

  Kainov, Denis E ^a,b   Vitorino, Marc ^a   Cavarelli, Jean ^a   Poterszman, Arnaud ^a   Egly, Jean Marc ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b LABORATOIRE NATIONAL DE SANTÉ   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR B2; TRANSCRIPTION FACTOR B5; TRANSCRIPTION FACTOR IIH; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; DNA REPAIR; ESCHERICHIA COLI; IMMUNOPRECIPITATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SURFACE PLASMON RESONANCE; TRICHOTHIODYSTROPHY; YEAST;

CRYSTALLOGRAPHY, X-RAY; DNA REPAIR; HUMANS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTOR TFIIH; TRANSCRIPTION, GENETIC; TRICHOTHIODYSTROPHY SYNDROMES;

EID: 51349101549     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1478     Document Type: Article

References (23)

1. Feaver, W.J. et al. Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair. Cell 75, 1379-1387 (1993).
2. Schaeffer, L. et al. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science 260, 58-63 (1993).
3. Hanawalt, P.C. Subpathways of nucleotide excision repair and their regulation. Oncogene 21, 8949-8956 (2002).
4. Feaver, W.J. et al. Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J. Biol. Chem. 272, 19319-19327 (1997).
5. Ranish, J.A. et al. Identification of TFB5, a new component of general transcription and DNA repair factor IIH. Nat. Genet. 36, 707-713 (2004).
6. Fregoso, M. et al. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Mol. Cell. Biol. 27, 3640-3650 (2007).
7. Kraemer, K.H. et al. Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship. Neuroscience 145, 1388-1396 (2007).
8. Dubaele, S. et al. Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients. Mol. Cell 11, 1635-1646 (2003).
9. Coin, F. et al. p8/TTD-A as a repair-specific TFIIH subunit. Mol. Cell 21, 215-226 (2006).
10. Zhou, Y., Kou, H. & Wang, Z. Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast. Nucleic Acids Res. 35, 861-871 (2007).
11. Botta, E. et al. Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. Hum. Mol. Genet. 11, 2919-2928 (2002).
12. Giglia-Mari, G. et al. A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Nat. Genet. 36, 714-719 (2004).
13. Marinoni, J.C. et al. Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. EMBO J. 16, 1093-1102 (1997).
14. Jawhari, A. et al. p52 mediates XPB function within the transcription/repair factor TFIIH. J. Biol. Chem. 277, 31761-31767 (2002).
15. Vitorino, M. et al. Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy. J. Mol. Biol. 368, 473-480 (2007).
16. Remaut, H. & Waksman, G. Protein-protein interaction through β-strand addition. Trends Biochem. Sci. 31, 436-444 (2006).
17. Chapados, B.R. et al. A. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell 116, 39-50 (2004).
18. Das, D. et al. The HhH domain of the human DNA repair protein XPF forms stable homodimers. Proteins 70, 1551-1563 (2008).
19. Coin, F., Oksenych, V. & Egly, J.-M. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26, 245-256 (2007).
20. Vermeulen, W. et al. Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder. Nat. Genet. 26, 307-313 (2000).
21. Balch, W.E., Morimoto, R.I., Dillin, A. & Kelly, J.W. Adapting proteostasis for disease intervention. Science 319, 916-919 (2008).
22. Giglia-Mari, G. et al. Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol. 4, e156 (2006).
23. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).