Ischaemia-modified albumin: Clinical utility and pitfalls in measurement

Journal of Clinical Pathology

Volumn 61, Issue 9, 2008, Pages 1025-1028

  Collinson, Paul O ^a,b   Gaze, D C ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CREATINE KINASE MB; HUMAN SERUM ALBUMIN; ISCHEMIA MODIFIED ALBUMIN; TROPONIN; TROPONIN I; BIOLOGICAL MARKER; COBALT; SERUM ALBUMIN;

ACUTE CORONARY SYNDROME; ALBUMIN COBALT BINDING TEST; CORONARY ARTERY BLOOD FLOW; DIAGNOSTIC TEST; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE PERFUSION; HUMAN; LABORATORY TEST; MEASUREMENT; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; BLOOD; CHEMISTRY; METABOLISM;

BIOLOGICAL MARKERS; COBALT; HUMANS; MYOCARDIAL ISCHEMIA; SENSITIVITY AND SPECIFICITY; SERUM ALBUMIN;

EID: 51349093435     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2007.053363     Document Type: Review

References (66)

1. Apple FS, Wu AH, Mair J, et al. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem 2005;51:810-24.
2. 3+. Eur J Biochem 1994;220:193-200.
3. Chan B, Dodsworth N, Woodrow J, et al. Site-specific N-terminal auto-degradation of human serum albumin. Eur J Biochem 1995;227:524-8.
4. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63.
5. Levine RL. Ischemia: from acidosis to oxidation. FASEB J 1993;7:1242-6.
6. Cobbe SM, Poole-Wilson PA. The time of onset and severity of acidosis in myocardial ischaemia. J Mol Cell Cardiol 1980;12:745- 60.
7. Berenshtein E, Mayer B, Goldberg C, et al. Patterns of mobilization of copper and iron following myocardial ischemia: possible predictive criteria for tissue injury. J Mol Cell Cardiol 1997;29:3025-34.
8. Chevion M, Jiang Y, Har-EI R, et al. Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury. Proc Natl Acad Sci U S A 1993;90:1102-6.
9. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia - a preliminary report. J Emerg Med 2000;19:311-5.
10. Bar-Or D, Winkler JV, Vanbenthuysen K, et al. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J 2001;141:985-91.
11. 2+ binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem 2001;268:42-7.
12. Marx G, Chevion M. Site-specific modification of albumin by free radicals. Reaction with copper(II) and ascorbate. Biochem J 1986;236:397-400.
13. Bhagavan NV, Lai EM, Rios PA, et al. Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial ischemia and myocardial infarction. Clin Chem 2003;49:581-5.
14. Mothes E, Faller P. Evidence that the principal Coll-binding site in human serum albumin is not at the N-terminus: implication on the albumin cobalt binding test for detecting myocardial ischemia. Biochemistry 2007;46:2267-74.
15. Wu AH, Valdes R Jr, Apple FS, et al. Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction [see comments]. Clin Chem 1994;40:900-7.
16. Collinson PO, Gaze DC, Stubbs PJ, et al. Diagnostic and prognostic role of cardiac troponin I (cTnI) measured on the DPC Immulite. Clin Biochem 2006.
17. Wu AH, Morris DL, Fletcher DR, et al. Analysis of the Albumin Cobart Binding (ACB) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction. Cardiovasc Toxicol 2001;1:147-51.
18. Christenson RH, Duh SH, Sanhai WR, et al. Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: a multicenter study. Clin Chem 2001;47:464-70.
19. Collinson P, Purcell IF, Gomma AH, et al. IMA release following angioplasty. Clin Chem 2003;49:A38-9.
20. Sinha MK, Vazquez JM, Calvino R, et al. Effects of balloon occlusion during percutaneous coronary intervention on circulating ischemia modified albumin and transmyocardial lactate extraction. Heart 2006;92:1852-3.
21. Quiles J, Roy D, Gaze D, et al. Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia. Am J Cardiol 2003;92:322-4.
22. Garrido IP, Roy D, Calvino R, et al. Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals. Am J Cardiol 2004;93:88-90.
23. Dusek J, St'asek J, Tichy M, et al. Prognostic significance of ischemia modified albumin after percutaneous coronary intervention. Clin Chim Acta 2006;367:77-80.
24. Cho DK, Choi JO, Kim SH, et al. Ischemia-modified albumin is a highly sensitive serum marker of transient myocardial ischemia induced by coronary vasospasm. Coron Artery Dis 2007;18:83-7.
25. Roy D, Quiles J, Sinha M, et al. Effect of direct-current cardioversion on ischemia-modified albumin levels in patients with atrial fibrillation. Am J Cardiol 2004;93:366-8.
26. Roy D, Quiles J, Sinha M, et al. Effect of radiofrequency catheter ablation on the biochemical marker ischemia modified albumin. Am J Cardiol 2004;94:234-6.
27. Sbarouni E, Georgiadou P, Panagiotakos D, et al. Ischaemia modified albumin in radiofrequency catheter ablation. Europace 2007;9:127-9.
28. Sinha MK, Roy D, Gaze DC, et al. Role of "ischemia modified albumin", a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes. Emerg Med J 2004;21:29-34.
29. Collinson PO, Gaze DC, Bainbridge K, et al. Utility of admission cardiac troponin and "ischemia modified albumin" measurements tor rapid evaluation and rule out of suspected acute myocardial infarction in the emergency department. Emerg Med J 2006;23:256- 61.
30. Abadie JM, Blassingame CL, Bankson DD. Albumin cobalt binding assay to rule out acute coronary syndrome. Ann Clin Lab Sci 2005;35:66-72.
31. Keating L, Benger JR, Beetham R, et al. The PRIMA study: presentation ischaemia-modified albumin in the emergency department. Emerg Med J 2006;23:764-8.
32. Worster A, Devereaux PJ, Heels-Ansdell D, et al. Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome. CMAJ 2005;172:1685-90.
33. Aparci M, Kardesoglu E, Ozmen N, et al. Prognostic significance of ischemia-modified albumin in patients with acute coronary syndrome. Coron Artery Dis 2007;18:367-73.
34. Peacock F, Morris DL, Anwaruddin S, et al. Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department. Am Heart J 2006;152:253-62.
35. Gaze DC, Crompton L, Collinson PO. Sample stability of ischemia modified albumin (IMA) as assessed by the Albumin Cobalt Binding (ACB™) test. Clin Chem 2003;49:A40.
36. Beetham R, Monk C, Keating L, et al. Effects of storage at -20°C on ischaemia-modified albumin results. Ann Clin Biochem 2006;43:500-2.
37. Gaze DC, Crompton L, Collinson P. Ischemia-modified albumin concentrations should be interpreted with caution in patients with low serum albumin concentrations. Med Princ Pract 2006;15:322-4.
38. Lee YW, Kim HJ, Cho YH, et al. Application of albumin-adjusted ischemia modified albumin index as an early screening marker for acute coronary syndrome. Clin Chim Acta 2007;384:24-7.
39. Maguire OC, O'Sullivan J, Ryan J, et al. Evaluation of the albumin cobalt binding (ACB) assay for measurement of ischaemia-modified albumin (IMA) on the Beckman Coulter LX-20. Ann Clin Biochem 2006;43:494-9.
40. van der Zee PM, Verberne HJ, van Straalen JP, et al. Ischemia-modified albumin measurements in symptom-limited exercise myocardial perfusion scintigraphy reflect serum albumin concentrations but not myocardial ischemia. Clin Chem 2005;51:1744-6.
41. Gidenne S, Ceppa F, Fontan E, et al. Analytical performance of the Albumin Cobalt Binding (ACB) test on the Cobas MIRA Plus analyzer. Clin Chem Lab Med 2004;42:455-61.
42. Apple FS, Quist HE, Otto AP, et al. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem 2002;48:1097- 100.
43. Lippi G, Brocco G, Salvagno GL, et al. High-workload endurance training may increase serum ischemia-modified albumin concentrations. Clin Chem Lab Med 2005;43:741-4.
44. Lippi G, Salvagno GL, Montagnana M, et al. Influence of physical exercise and relationship with biochemical variables of NT-pro-brain natriuretic peptide and ischemia modified albumin. Clin Chim Acta 2006;367:175-80.
45. Middleton N, Shave R, George K, et al. Novel application of flow propagation velocity and ischaemia-modified albumin in analysis of postexercise cardiac function in man. Exp Physiol 2006;91:511-9.
46. Zapico-Muniz E, Santalo-Bel M, Merce-Muntanola J, et al. Ischemia-modified albumin during skeletal muscle ischemia. Clin Chem 2004;50:1063-5.
47. Falkensammer J, Stojakovic T, Huber K, et al. Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia. Clin Chem Lab Med 2007;45:535-40.
48. Refaai MA, Wright RW, Parvin CA, et al. Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta 2006;366:264-8.
49. Roy D, Quiles J, Sharma R, et al. Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. Clin Chem 2004;50:1656- 60.
50. Hacker M, Hoyer HX, la Fougere C, et al. Effects of peripheral vascular intervention on ischemia-modified albumin. Coron Artery Dis 2007;18:375-9.
51. Sbarouni E, Georgiadou P, Theodorakis GN, et al. Ischemia-modified albumin in relation to exercise stress testing. J Am Coll Cardiol 2006;48:2482-4.
52. Troxler M, Thompson D, Homer-Vanniasinkam S. Ischaemic skeletal muscle increases serum ischaemia modified albumin. Eur J Vasc Endovasc Surg 2006;31:164-9.
53. Banu NS, Gaze DC, Bruce H, et al. Markers of muscle ischemia, necrosis, and inflammation following uterine artery embolization in the treatment of symptomatic uterine fibroids. Am J Obstet Gynecol 2007;196:213-5.
54. Kalay N, Cetinkaya Y, Basar E, et al. Use of ischemia-modified albumin in diagnosis of coronary artery disease. Coron Artery Dis 2007;18:633-7.
55. Kurz K, Voelker R, Zdunek D, et al. Effect of stress-induced reversible ischemia on serum concentrations of ischemia-modified albumin, natriuretic peptides and placental growth factor. Clin Res Cardiol 2007;96:152-9.
56. Senes M, Kazan N, Coskun O, et al. Oxidative and nitrosative stress in acute ischaemic stroke. Ann Clin Biochem 2007;44:43-7.
57. Abboud H, Labreuche J, Meseguer E, et al. Ischemia-modified albumin in acute stroke. Cerebrovasc Dis 2007;23:216-20.
58. Turedi S, Gunduz A, Mentese A, et al. Value of ischemia-modified albumin in the diagnosis of pulmonary embolism. Am J Emerg Med 2007;25:770-3.
59. Sharma R, Gaze DC, Pellerin D, et al. Ischemia-modified albumin predicts mortality in ESRD. Am J Kidney Dis 2006;47:493- 502.
60. Sharma R, Gaze DC, Pellerin D, et al. Evaluation of ischaemia-modified albumin as a marker of myocardial ischaemia in end-stage renal disease. Clin Sci (Lond) 2007;113:25-32.
61. Montagnana M, Lippi G, Regis D, et al. Evaluation of cardiac involvement following major orthopedic surgery. Clin Chem Lab Med 2006;44:1340-6.
62. Gugliucci A, Hermo R, Monroy C, et al. Ischemia-modified albumin levels in cord blood: a case-control study in uncomplicated and complicated deliveries. Clin Chim Acta 2005;362:155-60.
63. Prefumo F, Gaze DC, Papageorghiou AT, et al. First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development. Hum Reprod 2007;22:2029-32.
64. Collinson PO, Stubbs PJ. Are troponins confusing? Heart 2003;89:1285-7.
65. Borderie D, Allanore Y, Meune C, et al. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem 2004;50:2190-3.
66. Montagnana M, Lippi G, Volpe A, et al. Evaluation of cardiac laboratory markers in patients with systemic sclerosis. Clin Biochem 2006;39:913-7.