The extent of vacuolation in non-heart-beating porcine donor liver grafts prior to transplantation predicts their viability

Liver Transplantation

Volumn 14, Issue 9, 2008, Pages 1256-1265

  Monbaliu, Diethard ^a   Libbrecht, Louis ^a   De Vos, Rita ^a   Vekemans, Katrien ^a   Walter, Hugo ^b   Liu, Qiang ^a   Heedfeld, Veerle ^a   Goossens, Vera ^c   Pirenne, Jacques ^a   Roskams, Tania ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b INNOGENETICS   (Belgium)

^c Algonomics   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VACUOLE; CONTROLLED STUDY; DISEASE SEVERITY; HEART BEAT; HISTOPATHOLOGY; IMAGE ANALYSIS; LIVER BIOPSY; LIVER CELL DAMAGE; LIVER CONGESTION; LIVER GRAFT; LIVER ISCHEMIA; LIVER PARENCHYMA; LIVER SINUSOID; LIVER TRANSPLANTATION; NONHUMAN; ORGAN DONOR; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SCORING SYSTEM;

ANIMALS; BIOPSY; COLD TEMPERATURE; CYTOPLASM; GRAFT SURVIVAL; HEPATOCYTES; ISCHEMIA; LIVER; LIVER TRANSPLANTATION; MICROSCOPY, ELECTRON; REPERFUSION INJURY; RETROSPECTIVE STUDIES; RISK; SWINE; VACUOLES;

EID: 51349089293     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.21513     Document Type: Article

References (19)

1. Busuttil RW, Klintmalm G. Transplantation of the liver. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2005:915-928.
2. Monbaliu D, Crabbe T, Roskams T, Fevery J, Verwaest C, Pirenne J. Livers from non-heart-beating donors tolerate short periods of warm ischemia. Transplantation 2005;79: 1226-1230.
3. Abt PL, Desai NM, Crawford MD, Forman LM, Markmann JW, Olthoff KM, Markmann JF. Survival following liver transplantation from non-heart-beating donors. Ann Surg 2004;239:87-92.
4. Vilca MH, Rela M, Murphy G, Heaton N. Assessment of graft function before liver transplantation: quest for the lost ark? Transplantation 2000;70:560-565.
5. D'Alessandro AM, Kalayoglu M, Sollinger HW, Hoffmann RM, Reed A, Knechtle SJ, et al. The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation. Transplantation 1991;51:157-163.
6. Ma Y, Wang GD, Wu LW, Hu RD. Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats. World J Gastroenterol 2006; 12:4902-4905.
7. Li X, Elwell MR, Ryan AM, Ochoa R. Morphogenesis of postmortem hepatocyte vacuolation and liver weight increases in Sprague-Dawley rats. Toxicol Pathol 2003;31: 682-688.
8. Crowley H, Lewis WD, Gordon F, Jenkins R, Khettry U. Steatosis In donor and transplant liver biopsies. Hum Pathol 2000;31:1209-1213.
9. Franzen LE, Ekstedt M, Kechagias S, Bodin L. Semiquantitative evaluation overestimates the degree of steatosis in liver biopsies: a comparison to stereological point counting. Mod Pathol 2005; 18:912-916.
10. Vertemati M, Sabatella G, Minola E, Gambacorta M, Goffredi M, Vizzotto L. Morphometric analysis of primary graft non-function in liver transplantation. Histopathology 2005;46:451-459.
11. Monbaliu D, van Pelt J, De Vos R, Greenwood J, Parkkinen J, Crabbé T, et al. Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs. Liver Transpl 2007; 13: 239-247.
12. Monbaliu D, Vekemans K, Bogaerts H, Heedfeld V, Dubuisson C, Pirenne J. The influence of prolonging cold ischemia in porcine livers exposed to warm ischemia in a preclinical model of liver transplantation (abstract). Am J Transplant 2007;7:503.
13. Qing D, Han B. Tolerance limits of liver grafts with 30 minutes of warm ischemia to cold preservation in swine. Transplant Proc 2005;37:409-412.
14. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717-1721.
15. Doctor RB, Dahl RH, Salter KD, Fouassier L, Chen J, Fitz JG. ATP depletion in rat cholangiocytes leads to marked internalization of membrane proteins. Hepatology 2000; 31:1045-1054.
16. Trowell OA. The experimental production of watery vacuolation of the liver. J Physiol 1946;105:268-297.
17. Jurado F, Bujan J, Mora NP, Jimenez M, Arahuetes R, Bellon JM. A histopathological study of anoxic-resuscitated liver allografts. Histol Histopathol 1997;12:123-133.
18. Graber M, Lane B, Lamia R, Pastoriza-Munoz E. Bubble cells: renal tubular cells in the urinary sediment with characteristics of viability. J Am Soc Nephrol 1991;1:999-1004.
19. Casavilla A, Ramirez C, Shapiro R, Nghiem D, Miracle K, Bronsther O, et al. Experience with liver and kidney allografts from non-heart-beating donors. Transplantation 1995;59:197-203.