Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial

American Journal on Addictions

Volumn 17, Issue 5, 2008, Pages 387-391

  Fairbairn, Catharine E ^a   Dundon, William D ^a,b   Xie, Hu ^a   Plebani, Jennifer G ^a   Kampman, Kyle M ^a   Lynch, Kevin G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; COCAINE; PLACEBO; PROPRANOLOL; PSYCHOTROPIC AGENT;

ADULT; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HEALTH PROGRAM; HUMAN; MAJOR CLINICAL STUDY; MALE; PERCEPTION; SUBSTANCE ABUSE;

ADOLESCENT; ADULT; AMANTADINE; COCAINE-RELATED DISORDERS; DOPAMINE AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PROPRANOLOL; TREATMENT OUTCOME; VASODILATOR AGENTS; YOUNG ADULT;

EID: 51149108318     PISSN: 10550496     EISSN: 15210391     Source Type: Journal    
DOI: 10.1080/10550490802266078     Document Type: Article

References (19)

1. White L, Tursky B, Schwartz GE. Placebo: Theory, research, and mechanisms. New York: Guilford Press; 1985.
2. Kaptchuk TJ. Intentional ignorance: A history of blind assessment and placebo controls in medicine. Bull Hist Med. 1998;72:389-433.
3. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-412.
4. Kintz BL, Delprato DJ, Mettee DR, Persons CE, Schappe RH. The experimenter effect. Psychol Bull. 1965;63:223-232.
5. McRae C, Cherin E, Yamazaki TG, et al. Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Arch Gen Psychiatry. 2004;61:412-420.
6. Bausell RB, Lao L, Bergman S, Lee WL, Berman BM. Is acupuncture analgesia an expectancy effect? Preliminary evidence based on participants' perceived assignments in two placebo-controlled trials. Eval Health Prof. 2005;28:9-26.
7. Rabkin JG, Markowitz JS, Stewart J, et al. Howblind is blind? Assessment of patient and doctor medication guesses in a placebo-controlled trial of imipramine and phenelzine. Psychiatry Res. 1986;19:75-86.
8. Hughes JR, Krahn D. Blindness and the validity of the double-blind procedure. J Clin Psychopharmacol. 1985;5:138-142.
9. Fergusson D, Glass KC, Waring D, Shapiro S. Turning a blind eye: The success of blinding reported in a random sample of randomised, placebo controlled trials. BMJ. 2004;328:432.
10. Fisher S, Greenberg RP. How sound is the double-blind design for evaluating psychotropic drugs? J Nerv Ment Dis. 1993;181:345-350.
11. Perkins KA, DiMarco A, Grobe JE, Scierka A, Stiller RL, Nicotine discrimination in male and female smokers. Psychopharmacol. 1994;116:407-413.
12. Fishman J, Reynolds T, Riedel E. A retrospective investigation of an intensive outpatient substance abuse treatment program. Am J Drug Alcohol Abuse. 1999;25:185-196.
13. Schulz, KF, Grimes DA. Blinding in randomized trials: Hiding who got what. Lancet. 2002;359:696-700.
14. Wickizer T, Maynard C, Atherly A, et al. Completion rates of clients discharged from drug and alcohol treatment programs in Washington State. Am J Public Health. 1994;84:215-221.
15. Kampman KM, Dackis C, Lynch KG, et al. A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. Drug Alcohol Depend. 2006;85:129-137.
16. Chick J, Anton R, Checinski K, et al. A multicentre randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse, Alcohol Alcohol. 2000;35:587-593.
17. Bosworth HB. Medication treatment adherence. In: Bosworth HB, Oddone EZ Weinberger M, eds. Patient Treatment Adherence: Concepts, Interventions and Measurements. Mahwah, NJ: Lawrence Erlbaum Associates; 2006:158.
18. Landis JR, Koch GG. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics. 1977;33:363-374.
19. Fleiss JL. Statistical Methods for Rates and Proportions. 2nd ed. New York: Wiley Interscience; 1981.