Biological image-guided radiotherapy in rectal cancer: Is there a role for FMISO or FLT, next to FDG?

Acta Oncologica

Volumn 47, Issue 7, 2008, Pages 1237-1248

  Roels, Sarah ^a   Slagmolen, Pieter ^b   Nuyts, Johan ^a   Lee, John A ^c   Loeckx, Dirk ^b   Maes, Frederik ^b   Stroobants, Sigrid ^a   Penninckx, Freddy ^a   Haustermans, Karin ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; ANTINEOPLASTIC AGENT; FLUORODEOXYGLUCOSE F 18; FLUOROTHYMIDINE; FLUOROURACIL; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; CONTROLLED STUDY; HUMAN; IMAGING SYSTEM; POSITRON EMISSION TOMOGRAPHY; PREOPERATIVE CARE; PRIORITY JOURNAL; RECTUM CANCER; TUMOR VOLUME;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL HYPOXIA; COMBINED MODALITY THERAPY; DIDEOXYNUCLEOSIDES; FLUORODEOXYGLUCOSE F18; FLUOROURACIL; HUMANS; MISONIDAZOLE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECTAL NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR BURDEN;

EID: 51049123629     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/02841860802256434     Document Type: Article

References (32)

1. Movsas B, Hanlon AL, Lanciano R, Scher RM, Weiner LM, Sigurdson ER, et al. Phase I dose escalating trial of hyperfractionated pre-operative chemoradiation for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 1998;42:43-50.
2. Chan AK, Wong AO, Langevin J, Jenken D, Heine J, Buie D, et al. Preoperative chemotherapy and pelvic radiation for tethered or fixed rectal cancer: A phase II dose escalation study. Int J Radiat Oncol Biol Phys 2000;48:843-56.
3. Myerson RJ, Valentini V, Birnbaum EH, Cellini N, Coco C, Fleshman JW, et al. A phase I/II trial of three-dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma. Int J Radiat Oncol Biol Phys 2001;50:1299-308.
4. Ling CC, Humm J, Larson S, Amols H, Fuks Z, Leibel S, et al. Towards multidimensional radiotherapy (MD-CRT): Biological imaging and biological conformality. Int J Radiat Oncol Biol Phys 2000;47:551-60.
5. Yang Y, Xing L. Towards biologically conformal radiation therapy (BCRT): Selective IMRT dose escalation under the guidance of spatial biology distribution. Med Phys 2005;32:1473-84.
6. Roels S, Slagmolen P, Nuyts J, Loeckx D, Maes F, Vandecaveye V, et al. A protocol for image-guided dose-escalation in rectal cancer. Int J Radiat Oncol Biol Phys (submitted).
7. Been LB, Suurmeijer AJH, Cobben P, Jager P, Hoekstra HJ, Elsinga PH. [18F]FLT-PET in oncology: current status and opportunities. Eur J Nucl Med Mol Imaging 2004;31:1659-72.
8. Francis DL, Visvikis D, Costa DC, Arulampalam THA, Townsend C, Luthra SK, et al. Potential impact of [18F]3′-deoxy-3′-fluorothymidine versus [18F]fluoro-2-deoxy-D-glucose in positron emission tomography for colorectal cancer. Eur J Nucl Med Mol Imaging 2003;30:988-94.
9. Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996;41:31-9.
10. Koh WJ, Rasey JS, Evans ML, Grierson JR, Lewellen TK, Graham MM, et al. Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole. Int J Radiat Oncol Biol Phys 1992;22:199-212.
11. Eschmann SM, Paulsen F, Reimold M, Dittmann H, Welz S, Reischl G, et al. Prognosticimpact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy. J Nucl Med 2005;46:253-60.
12. Bruehlmeier M, Roelcke U, Schubiger PA, Ametamey SM. Assessment of hypoxia and perfusion in human brain tumors using PET with 18F- fluoromisonidazole and 15O-H2O. J Nucl Med 2004;45:1851-9.
13. Loi S, Ngan SY, Hicks RJ, Mukesh B, Mitchell P, Michael M, et al. Oxaliplatin combined with infusional 5-fluorouracil and concomitant radiotherapy in inoperable and metastatic rectal cancer: A phase I trial. Br J Cancer 2005;92:655-61.
14. Thorwarth D, Eschmann SM, Holzner F, Paulsen F, Thorwarth AM. Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients. Radiother Oncol 2006;80:151-6.
15. Rajendran JG, Wilson DC, Conrad EU, Peterson LM, Bruckner JD, Rasey JS, et al. [(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: Correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging 2003;30:695-704.
16. Balter JM, Kessler ML. Imaging and alignment for image-guided radiation therapy. J Clinic Oncol 2007;25:931-7.
17. Cascini GL, Avallone A, Delrio P, Guida C, Tatangelo F, Marone P, et al. 18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. J Nucl Med 2006;47:1241-8.
18. Eschmann SM, Paulsen F, Bedeshem C, Machulla HJ, Hehr T, Bamberg M, et al. Hypoxia-imaging with (18)F-Misonidazole and PET: Changes of kinetics during radiotherapy of head-and-neck cancer. Radiother Oncol 2007;83:406-10.
19. Nehmeh SA, Lee NY, Schröder H, Squire O, Zanzonico PB, Erdi YE, et al. Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer. Int J Radiat Oncol Biol Phys 2008;70:235-42.
20. Koh WJ, Bergman KS, Rasey JS, Peterson LM, Evans ML, Graham MM, et al. Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18] fluoromisonidazole positron emission tomography. Int J Radiat Oncol Biol Phys 1995;33:391-8.
21. Huang SC, McBride W, Stout D, Sitko J, Liao YP, Daigle J, et al. Post-irradiation temporal changes in glucose metabolism and cell proliferation in implanted murine tumors as measured by FDG and FLT PET. J Nucl Med 2002;43:25.
22. Geets X, Lee J, Bol A, Lonneux M, Grégoire V. A gradient-based method for segmenting FDG-PET images: Methodology and validation. Eur J Nucl Med Mol Imaging 2007;34:1427-38.
23. Slagmolen P, Loeckx D, Roels S, et al. Non-rigid registration of multi-temporal CT and MR images for radiotherapy treatment planning. In: Pluim JPW, Likar B, Gerritsen FA editors., WBIR 2006: Third International Workshop on biomedical image registration. Lecture Notes in computer science 4057. Berlin, Heidelberg: Springer-Verlag; 2006. p 297-305.
24. Rueckert D, Sonoda LI, Hayes C, Hill DL, Leach MO, Hawkes DJ. Nonrigid registration using free-form deformations: Application to breast MR images. IEEE Trans Med Imaging 1999;18:712\u201321.
25. Rohlfing T, Maurer CRJ, Bluemke DA, Jacobs MA. Volume-preserving nonrigid registration of MR breast images using free-form deformation with an incompressibility constraint. IEEE Trans Med Imaging 2003;22:730\u201341.
26. Daisne JF, Sibomana M, Bol A, Doumont T, Lonneux M, Grégoire V. Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: Influence of reconstruction algorithms. Radiother Oncol 2003;69:247-50.
27. Grégoire V, Bol A, Geets X, Lee J. Is PET-based treatment planning the new standard in modern radiotherapy? The Head and Neck paradigm. Semin Radiat Oncol 2006;16:232-8.
28. Dubois L, Landuyt W, Haustermans K, Dupont P, Bormans G, Vermaelen P, et al. Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry. Br J Cancer 2004;91:1947-54.
29. Troost EG, Vogel WV, Merkx MA, Slootweg PJ, Marres HA, Peeters WJ, et al. 18F-FLT PET does not discriminate between reactive and metastatic lymph nodes in primary head and neck cancer patients. J Nucl Med 2007;48:726-35.
30. Patel DA, Chang ST, Goodman KA, Quon A, Thorndyke B, Gambhir SS, et al. Impact of Integrated PET/CT on variability of target volume delineation in rectal cancer. Technol Cancer Res Treat 2007;6:31-6.
31. 18F]FLT uptake after chemotherapy: An experimental study. Eur J Nucl Med 2002;29:1462-9.
32. Lin Z, Mechalakos J, Nehmeh S, Schoder H, Lee N, Humm J, et al. The influence of changes in tumor hypoxia on dose-painting treatment plans based on (18)F-FMISO positron emission tomography. Int J Radiat Oncol Biol Phys 2008;70:1219-28.