Age-related changes in porosity and mineralization and in-service damage accumulation

Journal of Biomechanics

Volumn 41, Issue 13, 2008, Pages 2868-2873

  Norman, Timothy L ^a   Little, Tara M ^b   Yeni, Yener N ^c  

^a CEDARVILLE UNIVERSITY   (United States)

^b EPIC SYSTEMS CORPORATION   (United States)

^c HENRY FORD HOSPITAL   (United States)

Author keywords

Cortical bone; Diffuse damage; Linear microcracks; Mineralization; Porosity

Indexed keywords

ELASTICITY; MINERALOGY; POLARIZATION; POROSITY; SILICA; SILICATE MINERALS; STRUCTURAL DESIGN;

BONE TURNOVER; CORTICAL BONE; DIFFUSE DAMAGE; LINEAR MICROCRACKS; MINERALIZATION;

BONE;

ADULT; AGED; AGING; ARTICLE; BONE INJURY; BONE MINERAL; BONE MINERALIZATION; BONE REMODELING; BONE STRESS; BONE TURNOVER; CADAVER; CORTICAL BONE; DIFFUSE DAMAGE AREA; FEMALE; FEMUR; HUMAN; HUMAN TISSUE; MALE; MICROCRACK DENSITY; PARAMETER; POROSITY; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BONE DENSITY; BONE DEVELOPMENT; CADAVER; CALCIFICATION, PHYSIOLOGIC; FEMALE; FEMUR; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POROSITY; YOUNG ADULT;

EID: 51049123391     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2008.06.032     Document Type: Article

References (50)

1. Boyce T.M., and Bloebaum R.D. Cortical aging differences and fracture implications for the human femoral neck. Bone 14 5 (1993) 769-778
2. Boyce T.D., Fyhrie D.P., Glotkowski M.C., Radin E.L., and Schaffler M.B. Damage type and strain mode associations in human compact bone bending fatigue. Journal of Orthopaedic Research 16 (1998) 322-329
3. Burr D.B. Microdamage and bone strength. Osteoporosis International 14 Suppl. 5 (2003) S67-S72
4. Burr D.B., and Stafford T. Validity of the Bulk-staining technique to separate artifactual from in-vivo bone microdamage. Clinical Orthopaedics and Related Research 260 (1990) 305-308
5. Burr D.B., Turner C.H., Naick P., Forwood M.R., Ambrosius W., Hasan M.S., and Pidaparti R. Does microdamage accumulation affect the mechanical properties of bone?. Journal of Biomechanics 31 (1998) 337-345
6. Currey J.D. The mechanical consequences of variation in the mineral content of bone. Journal of Biomechanics 2 (1969) 1-11
7. Currey J.D. Changes in the impact energy absorption of bone with age. Journal of Biomechanics 12 (1979) 459-469
8. Currey J.D., Brear K., and Zioupos P. The effects of ageing and changes in mineral content in degrading the toughness of human femora. Journal of Biomechanics 12 2 (1996) 257-260
9. Diab T., and Vashishth D. Morphology, localization and accumulation of in vivo microdamage in human cortical bone. Bone 40 (2007) 612-618
10. Diab T., Sit S., Kim D., Rho J., and Vashishth D. Age-dependent fatigue behavior of human cortical bone. European Journal of Morphology 45 1/2 (2005) 53-59
11. Fazzalari N.L., Forwood M.R., Smith K., Mathey B.A., and Herreen P. Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 22 (1998) 381-388
12. Freeman M.A.R., Todd R.C., and Pirie C.J. The role of fatigue in the pathogenesis of senile femoral neck fractures. Journal of Bone and Joint Surgery 56B (1974) 698
13. Frost H.M. Presence of microscopic cracks in vivo in bone. Henry Ford Hospital Bulletin 8 (1960) 25-35
14. Frost H.M. Mathematical Elements of Lamellar Bone Remodeling (1964), Charles C. Thomas, Springfield, IL
15. Frost H.M. Bone microdamage: factors that impair its repair. In: Uhtoff H.D. (Ed). Current Concepts of Bone Fragility (1985), Springer, Berlin 123-148
16. Giladi M., Milgrom C., Simkin A., and Danon Y. Stress fractures: identifiable risk factors. American Journal of Sports Medicine 19 6 (1991) 647-652
17. Goldman H.M., Bromage T.G., Boyde A., Thomas C.D.L., and Clement J.G. Intrapopulation variability in mineralization density at the human femoral mid-shaft. Journal of Anatomy 203 (2003) 243-255
18. Heaney R.P. The natural history of vertebral osteoporosis. Is low bone mass an Epiphenomenon?. Bone 13 Suppl. 2 (1992) S23-S26
19. Jepsen K.J., Pennington D.E., Lee Y.L., Warman M., and Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6 inbred mice. Journal of Bone and Mineral Research 16 (2001) 1854-1862
20. Jowsey J. Age changes in human bone. Clinical Orthopaedics and Related Research (1960) 210-218
21. Li G., Zhang S., Chen H., and Wang A. Radiographic and histologic analyses of stress fracture in rabbit tibias. American Journal of Sports Medicine 13 5 (1985) 285-294
22. Martin R.B., Pickett J.C., and Zinaich S. Studies of skeletal remodeling in aging men. Clinical Orthopaedic and Related Research 149 (1980) 268-282
23. Martin R.B., Burr D.B., and Sharkey N.A. Skeletal Tissue Mechanics (1998), Springer, New York
24. Mashiba T., Hirano T., Turner C.H., Forward M.R., Johnson C.C., and Burr D.B. Suppressed bone turnoverby bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. Journal of Bone and Mineral Research 15 4 (2000) 613-620
25. Mashiba T., Turner C.H., Hirano T., Forward M.R., Johnson C.C., and Burr D.B. Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone 28 5 (2001) 524-531
26. Matheson G.O., Clement D.B., Mckenzie D.C., Taunton J.F., Lloyd-Smith D.R., and Macintyre J.G. Stress fracture in athletes: a study of 320 cases. American Journal of Sports Medicine 15 1 (1987) 46-59
27. McCalden R.W., McGeough J.A., Barker M.B., and Court-Brown C.M. Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. Journal of Bone Joint Surgery American 75 (1993) 1193-1205
28. Meunier P.J., and Boivin G. Influence of changes in bone remodeling rate in the degree of mineralization of bone: therapeutic implications. Journal Bone Mineral Research 15 (2000) 818-825
29. Mori S., Harruff R., Ambrosius W., and Burr D.B. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 21 (1997) 521-526
30. Norman T.L., and Wang Z. Microdamage of human cortical bone: incidence and morphology in long bones. Bone 20 4 (1997) 375-379
31. Parsamian G.P., and Norman T.L. Diffuse damage accumulation in the fracture process zone of human cortical bone specimens and its influence on fracture toughness. Journal of Materials Science: Materials in Medicine 12 (2001) 779-783
32. Rousseeuw P.J., and Leroy A.M. Robust Regression and Outlier Detection (1987), Wiley, New York
33. Schaffler M.B. Role of bone turnover in microdamage. Osteoporosis International 14 Suppl 5 (2003) S73-S80
34. Schaffler M.B., Radin E.L., and Burr D.B. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone 11 (1990) 321-326
35. Schaffler M.B., Pitchford W.C., Choi K., and Riddle J.M. Examination of compact bone microdamage using back-scattered electron microscopy. Bone 15 (1994) 483-488
36. Schaffler M.B., Choi K., and Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone 17 6 (1995) 521-525
37. Schaffler M.B., Boyce T.M., and Fyhrie D.P. Tissue and matrix failure modes in human compact bone during tensile fatigue. Transactions of Orthopaedic Research Society 21 (1996) 57
38. Sherman, S., Heaney, R.P., Parfitt, A.M., Hadley, E.C., Dutta, C., (Eds.), 1993. NIA workshop on aging and bone quality. Calcified Tissue International 53(Supplment 1), pp. S1-S180
39. Simmons E.D., Pritzker K.P.H., and Grynpas M.D. Age-related changes in the human femoral cortex. Journal of Orthopaedic Research 9 (1991) 155-167
40. Thompson D.D. Age changes in bone mineralization, cortical thickness and Haversian canal areal. Calcified Tissue International 31 1 (1980) 5-11
41. Vashishth D., Behiri J.C., and Bonfield W. Crack growth resistance in cortical bone: concept of microcrack toughening. Journal of Biomechanics 30 (1997) 763-769
42. Vashishth D., Koontz J., Qiu S.J., Lundin-Cannon D., Yeni Y.N., Schaffler M.B., and Fyhrie D.P. In vivo diffuse damage in human vertebral trabecular bone. Bone 2 2 (2000) 147-152
43. Wank, R., Jepsen, K.J., Nasser, P., Schaffler, M.B., 2001. Aged rat bone fatigues in a fundamentally different manner from yonder adult bone. 47 Annual Meeting, Orthopaedic Research Society, San Francisco, CA, February 25-28, 0111:2001.
44. Wasserman N., Yerramshetty J., and Akkus O. Microcracks colocalize within highly mineralized regions of cortical bone tissue. European Journal of Morphology 42 1/2 (2005) 43-51
45. Yeni Y.N., Brown C.U., Wang Z., and Norman T.L. Influence of bone morphology on fracture toughness of the human femur and tibia. Bone 21 5 (1997) 453-459
46. Yeni Y.N., Brown C.U., and Norman T.L. Influence of bone composition and apparent density on fracture toughness of the human femur and tibia. Bone 22 1 (1998) 79-84
47. Zarrinkalam K.H., Kuliwaba J.S., Martin R.B., Wallwork M.A.B., and Fazzalari N.L. New insights into the propagation of fatigue damage in cortical bone using confocal microscopy and chelating flurochromes. European Journal of Morphology 42 1/2 (2005) 81-90
48. Zioupos P. Ageing human bone: factors affecting the biomechanical properties and the role of collagen. Journal of Biomaterials Applications 15 (2001) 187-229
49. Zioupos P. Accumulation of in-vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone. Journal of Microscopy 201 (2001) 270-278
50. Zioupos P., and Currey J.D. The extent of microcracking and the morphology of microcracks in damaged bone. Journal Material Science 29 (1994) 978-986