In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 21002-21010

  Shimada, Masako ^a,b   Greer, Peter A ^c   McMahon, Andrew P ^d   Bouxsein, Mary L ^e   Schipani, Ernestina ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d HARVARD UNIVERSITY   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; C (PROGRAMMING LANGUAGE); CELL PROLIFERATION; MAMMALS;

CATALYTIC SUBUNITS; CELLULAR FUNCTION; CYSTEINE PROTEASE; IN-VITRO ANALYSIS; MATRIX MINERALIZATION; OSTEOBLAST FUNCTION; PARATHYROID HORMONES; REGULATORY SUBUNITS;

BONE;

CALPAIN; CALPAIN 1; CALPAIN 2; PROTEIN SUBUNIT; CAPNS1 PROTEIN, MOUSE; PARATHYROID HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTHROPOMETRY; ARTICLE; BODY SIZE; BONE MINERALIZATION; BONE REMODELING; CAPN4 GENE; CELL ACTIVITY; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; CORTICAL BONE; ENZYME ACTIVE SITE; FEMALE; GENE; GENE DELETION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LOXP SITE; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; TRABECULAR BONE; ANIMAL; BIOLOGICAL MODEL; BONE; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; CYTOLOGY; METABOLISM; METHODOLOGY; PROTEIN TERTIARY STRUCTURE;

MUS;

ANIMALS; BONE AND BONES; BONE REMODELING; CALPAIN; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; GENE DELETION; MICE; MODELS, BIOLOGICAL; OSTEOBLASTS; PARATHYROID HORMONE; PROTEIN STRUCTURE, TERTIARY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 51049114509     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710354200     Document Type: Article

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