-
1
-
-
0031303067
-
TGFβ-1 regulation of VEGF production by breast cancer cells
-
Donovan D, Harmey JH, Toomey D, Osborne DH, Redmond HP, Bouchier-Hayes DJ. TGFβ-1 regulation of VEGF production by breast cancer cells. Ann Surg Oncol 1997;4:621-7.
-
(1997)
Ann Surg Oncol
, vol.4
, pp. 621-627
-
-
Donovan, D.1
Harmey, J.H.2
Toomey, D.3
Osborne, D.H.4
Redmond, H.P.5
Bouchier-Hayes, D.J.6
-
2
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17:548-58.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
3
-
-
33846675282
-
Mechanisms underlying TGF-β1 -induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis
-
Jeon SH, Chae BC, Kim HA, et al. Mechanisms underlying TGF-β1 -induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. J Leukoc Biol 2007;81:557-66.
-
(2007)
J Leukoc Biol
, vol.81
, pp. 557-566
-
-
Jeon, S.H.1
Chae, B.C.2
Kim, H.A.3
-
4
-
-
0031106404
-
Transforming growth factor-β: Vasculogenesis, angiogenesis, and vessel wall integrity
-
Pepper MS. Transforming growth factor-β: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 1997;8:21-43.
-
(1997)
Cytokine Growth Factor Rev
, vol.8
, pp. 21-43
-
-
Pepper, M.S.1
-
5
-
-
0036086409
-
Blockade of TGF- β inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka RS, Dumont N, Ritter CA, et al. Blockade of TGF- β inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 2002;109:1551-9.
-
(2002)
J Clin Invest
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
-
6
-
-
0033797857
-
Plasma transforming growth factor β1 in breast cancer patients treated with CMF chemotherapy
-
Kajdaniuk M, Swietochowska, Ostrowska Z, et al. Plasma transforming growth factor β1 in breast cancer patients treated with CMF chemotherapy. J Clin Pharm Ther 2000;25:291-4.
-
(2000)
J Clin Pharm Ther
, vol.25
, pp. 291-294
-
-
Kajdaniuk, M.1
Swietochowska, O.Z.2
-
7
-
-
0034911060
-
Serum levels of transforming growth factor 1 in patients with breast cancer
-
Sheen-Chen SM, Chen HS, Sheen CW, Eng HL, Chen WJ. Serum levels of transforming growth factor 1 in patients with breast cancer. Arch Surg 2001;136: 937-40.
-
(2001)
Arch Surg
, vol.136
, pp. 937-940
-
-
Sheen-Chen, S.M.1
Chen, H.S.2
Sheen, C.W.3
Eng, H.L.4
Chen, W.J.5
-
8
-
-
33746701947
-
Elevated plasma TGF-β1 levels correlate with decreased survival of metastatic breast cancer patients
-
Ivanovic V, Demajo M, Krtolica K, et al. Elevated plasma TGF-β1 levels correlate with decreased survival of metastatic breast cancer patients. Clin Chim Acta 2006;371:191-3.
-
(2006)
Clin Chim Acta
, vol.371
, pp. 191-193
-
-
Ivanovic, V.1
Demajo, M.2
Krtolica, K.3
-
9
-
-
0028921873
-
Drug resistance and gene amplification potential regulated by transforming growth factor (VI gene expression
-
Aiping H. Drug resistance and gene amplification potential regulated by transforming growth factor (VI gene expression. Cancer Res 1995;55:1758-62.
-
(1995)
Cancer Res
, vol.55
, pp. 1758-1762
-
-
Aiping, H.1
-
10
-
-
0030993935
-
Reversal of in vivo drug resistance by the transforming growth factor-βinhibitor decorin. lnt
-
Teicher BA, Maehara Y, Kakeh Y, et al. Reversal of in vivo drug resistance by the transforming growth factor-βinhibitor decorin. lnt J Cancer 1998;71:49-58.
-
(1998)
J Cancer
, vol.71
, pp. 49-58
-
-
Teicher, B.A.1
Maehara, Y.2
Kakeh, Y.3
-
12
-
-
0034604110
-
Role of transforming growth factor β in human disease
-
Blobe GC, Schiemann WP, Lodish HF Role of transforming growth factor β in human disease. N Engl J Med 2000;342:1350-8.
-
(2000)
N Engl J Med
, vol.342
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
13
-
-
15744372725
-
Role of transforming growth factor β in human cancer
-
Elliott RL, Blobe GC. Role of transforming growth factor β in human cancer. J Clin Oncol 2005:23: 2078-93.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2078-2093
-
-
Elliott, R.L.1
Blobe, G.C.2
-
14
-
-
33746145265
-
Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor
-
Bandyopadhyay A, Agyin J, Wang L, etal. Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor. Cancer Res 2006:66:6714-21.
-
(2006)
Cancer Res
, vol.66
, pp. 6714-6721
-
-
Bandyopadhyay, A.1
Agyin, J.2
Wang, L.3
-
15
-
-
0037816160
-
-
Siegel PM, Shue W, Cardiff RD, Muller WJ, Massagué J. Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA2003;100:8430-5.
-
Siegel PM, Shue W, Cardiff RD, Muller WJ, Massagué J. Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA2003;100:8430-5.
-
-
-
-
16
-
-
0032888683
-
Factors regulating the growth of metastatic cancer in bone
-
Boyce BF, Yoneda T, Guise TA. Factors regulating the growth of metastatic cancer in bone. Endocr Relat Cancer 1999;6:333-47.
-
(1999)
Endocr Relat Cancer
, vol.6
, pp. 333-347
-
-
Boyce, B.F.1
Yoneda, T.2
Guise, T.A.3
-
17
-
-
33846034493
-
Breast cancer bone metastasis and current small therapeutics
-
Cicek M, Oursler M. Breast cancer bone metastasis and current small therapeutics. Cancer Metastasis 2006;25:635-44.
-
(2006)
Cancer Metastasis
, vol.25
, pp. 635-644
-
-
Cicek, M.1
Oursler, M.2
-
18
-
-
33744813556
-
Genes associated with breast cancer metastatic to bone
-
Smid M, Wang Y, Klijn JG, et al. Genes associated with breast cancer metastatic to bone. J Clin Oncol 2006;24:2261-7.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2261-2267
-
-
Smid, M.1
Wang, Y.2
Klijn, J.G.3
-
19
-
-
34347231588
-
Transforming growth factor-β signaling in breast cancer
-
Chang CF, Westbrook R, Ma J, Cao D. Transforming growth factor-β signaling in breast cancer. Front Biosci 2007;12:4393-401.
-
(2007)
Front Biosci
, vol.12
, pp. 4393-4401
-
-
Chang, C.F.1
Westbrook, R.2
Ma, J.3
Cao, D.4
-
21
-
-
0034468039
-
Transforming growth factor- β and breast cancer: Tumor promoting effects of transforming growth factor-β
-
Dumont N, Arteaga CL. Transforming growth factor- β and breast cancer: Tumor promoting effects of transforming growth factor-β Breast Cancer Res 2000;2: 125-32.
-
(2000)
Breast Cancer Res
, vol.2
, pp. 125-132
-
-
Dumont, N.1
Arteaga, C.L.2
-
22
-
-
25444515482
-
Targeting TGFβ signaling for cancer therapy
-
Iyer S, Wang ZG, Akhtari M, Zhao W, Seth P. Targeting TGFβ signaling for cancer therapy. Cancer Biol Ther 2005;4:261-66.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 261-266
-
-
Iyer, S.1
Wang, Z.G.2
Akhtari, M.3
Zhao, W.4
Seth, P.5
-
23
-
-
0036888335
-
Integration of the TGF-β pathway into the cellular signaling network
-
Lutz M, Knaus P. Integration of the TGF-β pathway into the cellular signaling network. Cell Signal 2002: 14;977-88.
-
(2002)
Cell Signal
, vol.14
, pp. 977-988
-
-
Lutz, M.1
Knaus, P.2
-
24
-
-
2342647439
-
PKB/Akt modulates TGF-β signaling through a direct interaction with Smad3
-
Remy I, Montmarquette A, Michnick SW. PKB/Akt modulates TGF-β signaling through a direct interaction with Smad3. Nat Cell Biol 2004;6:358-65.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 358-365
-
-
Remy, I.1
Montmarquette, A.2
Michnick, S.W.3
-
25
-
-
15244340251
-
TGFβ1, back to the future: Revisiting its role as a transforming growth factor
-
Glick AB.TGFβ1, back to the future: revisiting its role as a transforming growth factor. Cancer Biol Ther 2004;3:276-83.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 276-283
-
-
Glick, A.B.1
-
26
-
-
0034711307
-
Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
-
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000;275:36803-10.
-
(2000)
J Biol Chem
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
27
-
-
0027137485
-
Anti-transforming growth factor (TGF) -β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression
-
Arteaga CL, Hurd SD, Winnier AR, Johnson MD, Fendly BM, Forbes JT. Anti-transforming growth factor (TGF) -β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression. J Clin Invest 1993;92:2569-76.
-
(1993)
J Clin Invest
, vol.92
, pp. 2569-2576
-
-
Arteaga, C.L.1
Hurd, S.D.2
Winnier, A.R.3
Johnson, M.D.4
Fendly, B.M.5
Forbes, J.T.6
-
28
-
-
0037474223
-
Autocrine transforming growth factor-β signaling mediates Smadindependent motility in human cancer cells
-
Dumont N, Bakin AV, Arteaga CL. Autocrine transforming growth factor-β signaling mediates Smadindependent motility in human cancer cells. J Biol Chem 2003;278:3275-85.
-
(2003)
J Biol Chem
, vol.278
, pp. 3275-3285
-
-
Dumont, N.1
Bakin, A.V.2
Arteaga, C.L.3
-
29
-
-
34547587877
-
Cell size and invasion in TGF-{β} induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
-
Lamouille S, Derynck R. Cell size and invasion in TGF-{β} induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 2007;178:437-51.
-
(2007)
J Cell Biol
, vol.178
, pp. 437-451
-
-
Lamouille, S.1
Derynck, R.2
-
30
-
-
6944248910
-
Activation of the Erk pathway is required for TGF- & beta1-induced EMT in vitro
-
Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL. Activation of the Erk pathway is required for TGF- & beta1-induced EMT in vitro. Neoplasia 2004;6: 603-10.
-
(2004)
Neoplasia
, vol.6
, pp. 603-610
-
-
Xie, L.1
Law, B.K.2
Chytil, A.M.3
Brown, K.A.4
Aakre, M.E.5
Moses, H.L.6
-
31
-
-
0031035582
-
Evidence for a role of Rho-like GTPases and stressactivated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling
-
Atfi A, Dejelloul S, Chastre E, Davis R, Gespach C. Evidence for a role of Rho-like GTPases and stressactivated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling. J Biol Chem 1997;272:1429-32.
-
(1997)
J Biol Chem
, vol.272
, pp. 1429-1432
-
-
Atfi, A.1
Dejelloul, S.2
Chastre, E.3
Davis, R.4
Gespach, C.5
-
32
-
-
0034023127
-
Role of Ras and Mapks in TGFβ signaling
-
Mulder KM. Role of Ras and Mapks in TGFβ signaling. Cytokine Growth Factor Rev 2000;11:23-35.
-
(2000)
Cytokine Growth Factor Rev
, vol.11
, pp. 23-35
-
-
Mulder, K.M.1
-
33
-
-
28544450380
-
Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21- activated kinase-2
-
Wilkes MC, Mitchell H, Penheiter SG, et al. Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21- activated kinase-2. Cancer Res 2005;65:10431-40.
-
(2005)
Cancer Res
, vol.65
, pp. 10431-10440
-
-
Wilkes, M.C.1
Mitchell, H.2
Penheiter, S.G.3
-
35
-
-
0035710746
-
Analysis of relative gene expression data using real time quantitative PCR and the 2-ΔΔCT Method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real time quantitative PCR and the 2-ΔΔCT Method. Methods 2001;25:402-8.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
36
-
-
10844295093
-
Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase 1 receptor
-
Mahendra G, Kumar S, Isayeva T, Ponnazhagan S. Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase 1 receptor. Cancer Gene Ther 2005;12:26-34.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 26-34
-
-
Mahendra, G.1
Kumar, S.2
Isayeva, T.3
Ponnazhagan, S.4
-
37
-
-
0142104985
-
Smad-dependent and Smadindependent pathways in TGF-β family signaling
-
Derynck R, Zhang YE. Smad-dependent and Smadindependent pathways in TGF-β family signaling. Nature 2003;425:577-84.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
38
-
-
0023925274
-
Transforming growth factor- β: Possible roles in carcinogenesis
-
Roberts AB, Thompson NL, Heine U, Flanders C, Sporn MB. Transforming growth factor- β: possible roles in carcinogenesis. Br J Cancer 1998;57:594-600.
-
(1998)
Br J Cancer
, vol.57
, pp. 594-600
-
-
Roberts, A.B.1
Thompson, N.L.2
Heine, U.3
Flanders, C.4
Sporn, M.B.5
-
39
-
-
0033381357
-
The role for transforming growth factor-β. (TGF-β) in human cancer
-
Gold L. The role for transforming growth factor-β. (TGF-β) in human cancer. Crit Rev Oncog 1999;10: 303-60.
-
(1999)
Crit Rev Oncog
, vol.10
, pp. 303-360
-
-
Gold, L.1
-
40
-
-
12544257249
-
Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo
-
Kamaraju AK, Roberts AB. Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem 2005;280:1024-36.
-
(2005)
J Biol Chem
, vol.280
, pp. 1024-1036
-
-
Kamaraju, A.K.1
Roberts, A.B.2
-
41
-
-
0029893734
-
Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor- β1 on gene expression
-
Mucsi I, Skorecki KL, Goldberg HJ. Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor- β1 on gene expression. J Biol Chem 1996;271:16567-72.
-
(1996)
J Biol Chem
, vol.271
, pp. 16567-16572
-
-
Mucsi, I.1
Skorecki, K.L.2
Goldberg, H.J.3
-
42
-
-
34247100316
-
ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells
-
Safina A, Vandette E, Bakin AV. ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells. Oncogene 2007;26: 2407-22.
-
(2007)
Oncogene
, vol.26
, pp. 2407-2422
-
-
Safina, A.1
Vandette, E.2
Bakin, A.V.3
-
43
-
-
15444372825
-
Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL. Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 2005; 280:10870-6.
-
(2005)
J Biol Chem
, vol.280
, pp. 10870-10876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
44
-
-
34447103569
-
Rho activation is required for transforming growth factor-β-induced epithelial-mesenchymal transition in lens epithelial cells
-
Cho HJ, Yoo J. Rho activation is required for transforming growth factor-β-induced epithelial-mesenchymal transition in lens epithelial cells. Cell Biol Int 2007;31:1225-30.
-
(2007)
Cell Biol Int
, vol.31
, pp. 1225-1230
-
-
Cho, H.J.1
Yoo, J.2
-
45
-
-
30444434212
-
Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation
-
Song K, Wang H, Krebs TL, Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation. EMBO J 2006;25:58-69.
-
(2006)
EMBO J
, vol.25
, pp. 58-69
-
-
Song, K.1
Wang, H.2
Krebs, T.L.3
Danielpour, D.4
-
46
-
-
39749166405
-
-
Involvement of PI3K/Akt pathway in TGF-β2 mediated epithelial mesenchymal transition in human lens epithelial cells. Ophthalmic Res 2008;40.69-76
-
Involvement of PI3K/Akt pathway in TGF-β2 mediated epithelial mesenchymal transition in human lens epithelial cells. Ophthalmic Res 2008;40.69-76
-
-
-
-
47
-
-
33748063941
-
-
McCubrey JA, Steelman LS. Abrams SL. Libra M Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 2006;46:249-79.
-
McCubrey JA, Steelman LS. Abrams SL. Libra M Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 2006;46:249-79.
-
-
-
-
48
-
-
30644467227
-
Inhibition of TGFβ signaling in cancer therapy
-
Arteaga CL. Inhibition of TGFβ signaling in cancer therapy. Curr Opin Genet Dev 2006;16:30-7
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 30-37
-
-
Arteaga, C.L.1
-
49
-
-
33845979811
-
The type III TGF-β receptor suppresses breast cancer progression
-
Dong M. How T, Kirkbride KC, et al. The type III TGF-β receptor suppresses breast cancer progression. J Clin Invest 2007;117:206-17
-
(2007)
J Clin Invest
, vol.117
, pp. 206-217
-
-
Dong, M.1
How, T.2
Kirkbride, K.C.3
-
50
-
-
0038724672
-
Targeting the TGF β signaling network in human neoplasia
-
Dumont N. Artega CL. Targeting the TGF β signaling network in human neoplasia Cancer Cell 2003:3 531-6.
-
(2003)
Cancer Cell
, vol.3
, pp. 531-536
-
-
Dumont, N.1
Artega, C.L.2
-
51
-
-
7444226411
-
-
Uhl M, Aulwurm S, Wischussen J. Weller M. SD- 208. a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 2004; 64:7954-61
-
Uhl M, Aulwurm S, Wischussen J. Weller M. SD- 208. a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 2004; 64:7954-61
-
-
-
|