A morphologic and immunohistochemical study of nasal mucosa in leatherworkers

American Journal of Rhinology

Volumn 22, Issue 4, 2008, Pages 356-360

  Palomba, Annarita ^a   Iaia, Tonina Enza ^b   Biancalani, Mauro ^c   Conti, Stefano ^d   Battista, Giussepe ^e   Papaleo, Bruno ^f   Alessandro, Franchi ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b USL11 ^*  (Italy)

^c SAN GIUSEPPE HOSPITAL   (Italy)

^d Division of Otolaryngology Head and Neck Surgery   (Italy)

^e UNIVERSITY OF SIENA   (Italy)

^f National Department of Health and Safety   (Italy)

Author keywords

Goblet hyperplasia; Histopathology; Immunohistochemistry; Intestinal metaplasia; Intestinal type adenocarcinoma; Leather workers; Nasal cavity; Nasal mucosa; Occupational tumors; Respiratory epithelium

Indexed keywords

CYTOKERATIN 20; MUCIN 2; TRANSCRIPTION FACTOR CDX2;

ADULT; AGED; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DYSPLASIA; EPITHELIUM CELL; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDUSTRIAL WORKER; LEATHER INDUSTRY; MAJOR CLINICAL STUDY; MALE; NASAL BIOPSY; NOSE DISEASE; NOSE MUCOSA; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; PHENOTYPE; PROTEIN DETERMINATION; RISK ASSESSMENT; RISK FACTOR; SMOKING HABIT; SQUAMOUS CELL METAPLASIA;

ADENOCARCINOMA; ADULT; AGED; BIOPSY; GOBLET CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-20; MALE; MIDDLE AGED; MUCINS; NASAL MUCOSA; NOSE NEOPLASMS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PRECANCEROUS CONDITIONS; TANNING; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 51049092672     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2008.22.3201     Document Type: Article

References (28)

1. Bussi M, Gervasio CF, Riontino E, et al. Study of ethmoidal mucosa in a population at occupational high risk of sinonasal adenocarcinoma. Acta Otolaryngol 122:197-201, 2002.
2. Skarsgard DP, Groome PA, Mackillop WJ, et al. Cancer of the upper aerodigestive tract in Ontario, Canada, and United States. Cancer 88:1728-1738, 2000.
3. Franchi A, Santucci M, Wenig B, et al. Adenocarcinoma. In Pathology and Genetics of Head and Neck Tumours. Barnes L, Eveson JW, Reichart P, and Sidransky D (Eds). Lion: IARC Press, 20-23, 2005.
4. Bimbi G, Saraceno MS, Riccio S, et al. Adenocarcinoma of ethmoid sinus: An occupational disease. Acta Otorhinolaryngol Ital 24:199-203, 2004.
5. Franchi A, Massi D, Palomba A, et al. CDX-2, cytokeratin 7 and cytokeratin 20 immunohistochemical expression in the differential diagnosis of primary adenocarcinomas of the sinonasal tract. Virchows Arch 445:63-67, 2004.
6. Battista G, Comba P, Orsi D, et al. Nasal cancer in leather workers: An occupational disease. J Cancer Res Clin Oncol 121:1-6, 1995.
7. Wilhelmsson B, and Lundh B. Nasal epithelium in woodworkers in the forniture industry. A histological and cytological study. Acta Otolaryngol 98:321-334, 1984.
8. Kennedy MT, Jordan RCK, Bearen KW, et al. Expression pattern of CK7, CK20, CDX-2 and villin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol 57:932-937, 2004.
9. Choi HR, Sturgis EM, Rashid A, et al. Sinonasal adenocarcinoma: Evidence for histogenetic divergence of the enteric and nonenteric phenotypes. Hum Pathol 34:1101-1107, 2003.
10. Wilhelmsson B, Hellquist H, Olofsson J, et al. Nasal cuboidal metaplasia with dysplasia. Precursor to adenocarcinoma in wood-dust-exposed workers? Acta Otolaryngol 99:641-648, 1985.
11. Aust MR, Madsen CS, Jnnings A, et al. Mucin mRNA expression in normal and vasomotor inferior turbinates. Am J Rhinol 11:293-302, 1997.
12. Takeuchi K, Yuta A, and Sakakura Y. MUC2 mucin gene expression in the nose and maxillary sinus. Am J Otolaryngol 16:391-395, 1995.
13. Iaia TE, Farina G, Ferraro MT, et al. A series of cases of sinonasal cancer among shoemakers and tannery workers. Epidemiol Prev 28:169-173, 2004.
14. Iaia TE, Bartoli D, Calzoni P, et al. Cohort study of mortality among leather tanners in the Lower Valdarno area. Med Lav 93:95-107, 2002.
15. Bianco MA, Handaji A, and Savolainen H. Quantitative analysis of ellagic acid in hardwood samples. Sci Total Environ 222:123-126, 1988.
16. Bianco MA, and Savolainen H. Woodworkers' exposure to tannins. J Appl Toxicol 14:293-295, 1994.
17. Kirby KS. Induction of tumours by tannin extracts. Br J Cancer 14:147, 1960.
18. Reddy JK, Chiga M, Harris CC, et al. Polyribosome disaggregation in rat liver following administration of tannic acid. Cancer Res 30:58, 1970.
19. Audie JP, Janin A, Porchet N, et al. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ ibridization. J Histochem Cytochem 41:1479-1485, 1993.
20. Rose MC, Nickola TJ, Voynow JA, et al. Airway mucus obstruction: Mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am J Respir Cell Mol Biol 25:533-537, 2001.
21. Gum JR, Hicks JW, Swallow DM, et al. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem 264:6480-6487, 1984.
22. Jany BH, Gallup MV, Yan PS, et al. Human bronchus and intestine express the same mucin gene. J Clin Invest 87:77-82, 1991.
23. Dechun L, Wang D, Majumdar S, et al. Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis. J Pathol 181: 305-310, 1997.
24. Voynow JA, Selby DM, and Rose MC. Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Lung 176:345-354, 1998.
25. Kim SS, Kim Ks, Lee JG, et al. Levels of intracellular protein and messenger RNA of mucin and lysozyme in normal human nasal and polyp epithelium. Laryngoscope 110:276-280, 2000.
26. Martinez-Anton A, deBolos C, Garrido M, et al. Mucin genes have different expression patterns in healthy and diseased upper airway mucosa. Clin Exp Allergy 36:448-457, 2006.
27. Cathro HP, and Mills SE. Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas: An immunohistochemical study of 22 cases utilizing CDX2 and MUC2. Am J Surg Pathol 28:1026-1032, 2004.
28. Perrone F, Oggionni M, Birindelli S, et al. TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Int J Cancer 105:196-203, 2003.