The oxidation of methionine-54 of epoetinum alfa does not affect molecular structure or stability, but does decrease biological activity

PDA Journal of Pharmaceutical Science and Technology

Volumn 62, Issue 3, 2008, Pages 211-223

  Labrenz, Steven R ^a   Calmann, Melissa A ^a   Heavner, George A ^b   Tolman, Glen ^a  

^a Global Biologics Supply Chain   (United States)

^b CENTOCOR INC   (United States)

Author keywords

Conformation; Epoetinum alpha; Methionine; Oxidation; Peroxide; Potency

Indexed keywords

HYDROGEN PEROXIDE; METHIONINE; METHIONINE SULFOXIDE; POTASSIUM IODIDE; RECOMBINANT ERYTHROPOIETIN; TERT BUTYL HYDROPEROXIDE; TRYPTOPHAN; ANTIANEMIC AGENT; DRUG DERIVATIVE;

ALLOSTERISM; AMINO ACID METABOLISM; ARTICLE; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG OXIDATION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; ENVIRONMENTAL CHANGE; PROTEIN ANALYSIS; PROTEIN FUNCTION; RECEPTOR BINDING; SPECTRAL SENSITIVITY; STRUCTURE ACTIVITY RELATION; TEMPERATURE SENSITIVITY; THERMODYNAMICS; CELL LINE; CHEMISTRY; OXIDATION REDUCTION REACTION; PROTEIN BINDING; PROTEIN FOLDING; TEMPERATURE;

ALLOSTERIC REGULATION; CELL LINE; CIRCULAR DICHROISM; DRUG STABILITY; EPOETIN ALFA; HEMATINICS; HYDROGEN PEROXIDE; METHIONINE; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN FOLDING; TEMPERATURE; TERT-BUTYLHYDROPEROXIDE; THERMODYNAMICS;

EID: 50949134465     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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