Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers

PLoS Computational Biology

Volumn 4, Issue 8, 2008, Pages

  Hao, Jihua ^a   Serohijos, Adrian W R ^b,c   Newton, Gail ^d,h   Tassone, Gina ^d,i   Wang, Zuncai ^d   Sgroi, Dennis C ^d   Dokholyan, Nikolay V ^b,e   Basilion, James P ^a,f,g  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f Case Western Reserve University   (United States)

^g CASE WESTERN RESERVE UNIVERSITY   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; DISEASES; LIGANDS;

BINDING AFFINITIES; CONSENSUS SEQUENCE; HIGH AFFINITY; HIGH AFFINITY LIGANDS; PEPTIDE LIGAND; PEPTIDE STRUCTURES; PHAGE LIBRARIES; PHAGE-DISPLAY; RATIONAL REDESIGN; SEQUENCE MOTIFS;

PEPTIDES;

A1 PEPTIDE; B5 PEPTIDE; BINDING PROTEIN; BIOLOGICAL MARKER; CYSTEINE RICH INTESTINAL PROTEIN 1; LIGAND; CARRIER PROTEIN; CRIP1 PROTEIN, HUMAN; PEPTIDE; PEPTIDE LIBRARY; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER DIAGNOSIS; LIGAND BINDING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PHAGE DISPLAY; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; BINDING COMPETITION; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COLIPHAGE; DRUG ANTAGONISM; DRUG POTENTIATION; HUMAN; METHODOLOGY; PROTEIN BINDING; PROTEIN MOTIF; SYNTHESIS; THERMODYNAMICS;

AMINO ACID MOTIFS; BINDING, COMPETITIVE; CARRIER PROTEINS; COLIPHAGES; COMPUTATIONAL BIOLOGY; HUMANS; LIGANDS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; THERMODYNAMICS;

EID: 50949117526     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000138     Document Type: Article

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