Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: No evidence of mitochondrial damage with highly active antiretroviral therapy

AIDS

Volumn 22, Issue 10, 2008, Pages 1226-1229

  Matsukura, Motoi ^a   Chu, Fanny F S ^b   Au, May ^a   Lu, Helen ^a   Chen, Jennifer ^a   Rietkerk, Sonja ^c   Barrios, Rolando ^d   Farley, John D ^a   Montaner, Julio S ^d   Montessori, Valentina C ^d   Walker, David C ^a,b   Côté, Hélène C F ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL RNA; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADULT; ARTICLE; CELL SIZE; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACTIVITY; GENE EXPRESSION; GENOTYPE; GLYCOGEN LIVER LEVEL; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LIPID LIVER LEVEL; LIVER BIOPSY; LIVER CELL; MALE; MITOCHONDRIAL TOXICITY; MITOCHONDRIAL VOLUME DENSITY; MIXED INFECTION; PRIORITY JOURNAL; COHORT ANALYSIS; LIVER MITOCHONDRION; MIDDLE AGED; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; DNA, MITOCHONDRIAL; HEPATITIS C, CHRONIC; HIV INFECTIONS; HUMANS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MITOCHONDRIA, LIVER;

EID: 50949116199     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328303be16     Document Type: Article

References (24)

1. Bica I, McGovern B, Dhar R, et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 2001; 32:492-497.
2. Monga HK, Rodriguez-Barradas MC, Breaux K, et al. HepatitisC virus infection-related morbidity and mortality among patients with human immunodeficiency virus infection. Clin Infect Dis 2001; 33:240-247.
3. Sherman KE, Peters M, Koziel MJ. HIV and liver disease forum: conference proceedings. Hepatology 2007; 45:1566-1577.
4. Pineda JA, Romero-Gomez M, Diaz-Garcia F, et al. HIV coinfection shortens the survival of patients with hepatitis C virusrelated decompensated cirrhosis. Hepatology 2005; 41:779-789.
5. Sulkowski MS, Benhamou Y. Therapeutic issues in HIV/HCVcoinfected patients. J Viral Hepat 2007; 14:371-386.
6. Rosenthal E, Pialoux G, Bernard N, et al. Liver-related mortality in human-immunodeficiency-virus-infected patients between 1995 and 2003 in the French GERMIVIC Joint Study Group Network (MORTAVIC 2003 Study). J Viral Hepat 2007; 14:183-188.
7. Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat Rev Drug Discov 2003; 2:812-822.
8. Cote HC. Mechanisms of antiretroviral therapy-induced mitochondrial dysfunction. Curr Opin HIV AIDS 2007; 2:253-260.
9. Van Huyen JP, Batisse D, Heudes D, et al. Alteration of cytochrome oxidase subunit I labeling is associated with severe mitochondriopathy in NRTI-related hepatotoxicity in HIV patients. Mod Pathol 2006; 19:1277-1288.
10. Verucchi G, Calza L, Biagetti C, et al. Ultrastructural liver mitochondrial abnormalities in HIV/HCV-coinfected patients receiving antiretroviral therapy. J Acquir Immune Defic Syndr 2004; 35:326-328.
11. Cote HC, Brumme ZL, Craib KJ, et al. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N Engl J Med 2002; 346:811-820.
12. Cote HC, Yip B, Asselin JJ, et al. Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens. J Infect Dis 2003; 187:1972-1976.
13. Gundersen HJ, Bendtsen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. Apmis 1988; 96:379-394.
14. Reith A, Mayhew TM. Stereology and morphometry in electron microscopy: problems and solutions. New York: Hemisphere Pub. Corp.; 1988.
15. Howard V, Reed MG. Unbiased stereology: three-dimensional measurement in microscopy. 2nd ed. Abingdon, Oxon; New York: Garland Science/BIOS Scientific Publishers; 2005.
16. Brau N. Chronic hepatitis C in patients with HIV/AIDS: a new challenge in antiviral therapy. J Antimicrob Chemother 2005; 56:991-995.
17. Lafeuillade A, Hittinger G, Chadapaud S. Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection. Lancet 2001; 357:280-281.
18. Walker UA, Setzer B, Venhoff N. Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors. AIDS 2002; 16:2165-2173.
19. Walker UA, Bauerle J, Laguno M, et al. Depletion of mitochondrial DNA in liver under antiretroviral therapy with didano-sine, stavudine, or zalcitabine. Hepatology 2004; 39:311-317.
20. Wnuk AM. Liver damage in HIV-infected patients. Med Sci Monit 2001; 7:729-736.
21. Fromenty B, Berson A, Pessayre D. Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation. J Hepatol 1997; 26 (Suppl 1):13-22.
22. Perlemuter G, Bigorgne A, Cassard-Doulcier AM, Naveau S. Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nat Clin Pract Endocrinol Metab 2007; 3:458-469.
23. Abid K, Pazienza V, de Gottardi A, et al. An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J Hepatol 2005; 42:744-751.
24. Weber R, Sabin CA, Friis-Moller N, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: the DAD study. Arch Intern Med 2006; 166:1632-1641.