Characterization of the C-terminal half of human juvenile myoclonic epilepsy protein EFHC1: Dimer formation blocks Ca2+ and Mg2+ binding to its functional EF-hand

Archives of Biochemistry and Biophysics

Volumn 477, Issue 1, 2008, Pages 131-138

  Murai, Marcelo J ^a   Sassonia, Rogério C ^a   Zamboni, André H ^a   Conte, Fábio F ^a   Martins de Souza, Daniel ^a   Aparicio, Ricardo ^a   de Oliveira, Marcelo G ^a   Lopes Cendes, Iscia ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Dimerization; Divalent ion binding; DM10 domain; EF hand motif; EFHC1; Isothermal titration calorimetry

Indexed keywords

CALCIUM; CALCIUM BINDING PROTEIN; MAGNESIUM; PROTEIN EFHC1;

ARTICLE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DIMERIZATION; DISULFIDE BOND; GEL PERMEATION CHROMATOGRAPHY; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; MYOCLONUS EPILEPSY; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; CHROMATOGRAPHY, GEL; DIMERIZATION; DNA PRIMERS; HUMANS; MAGNESIUM; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MYOCLONIC EPILEPSY, JUVENILE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 50949092744     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.06.008     Document Type: Article

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