Effective suppression of HIV-1 by artificial bispecific miRNA targeting conserved sequences with tolerance for wobble base-pairing

Biochemical and Biophysical Research Communications

Volumn 374, Issue 2, 2008, Pages 214-218

  Son, Jiyeon ^a   Uchil, Pradeep D ^b   Kim, Young Bong ^c   Shankar, Premlata ^d   Kumar, Priti ^d   Lee, Sang Kyung ^a  

^a Hanyang University   (South Korea)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Konkuk University   (South Korea)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Conserved; HIV; Lentivirus; miRNA; RNA interference; shRNA; siRNA; Wobble

Indexed keywords

BISPECIFIC MICRORNA; MICRORNA; TRANSACTIVATOR PROTEIN; VIF PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; CELL STRAIN HEK293; CLADISTICS; EMBRYO; GENE CONTROL; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; GENETIC CONSERVATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE; RNA INTERFERENCE; VIRUS GENE; VIRUS GENOME; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS REPLICATION;

BASE PAIRING; CELL LINE; CONSERVED SEQUENCE; GENE SILENCING; GENES, REPORTER; GENETIC VECTORS; HIV-1; HUMANS; MICRORNAS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

EID: 50949086562     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.125     Document Type: Article

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