Does 'ENHANCE' diminish confidence in Ezetimibe?

Journal of Association of Physicians of India

Volumn 56, Issue SEPTEMBER, 2008, Pages 665-666

  Gandhi, M J ^a  

^a Nanavati Heart Institute   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; EZETIMIBE; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN;

CORONARY ARTERY DISEASE; DRUG EFFECT; EDITORIAL; HUMAN;

ANTICHOLESTEREMIC AGENTS; AZETIDINES; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; HUMANS; SIMVASTATIN;

EID: 50949085405     PISSN: 00045772     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (8)

1. Jackevicius C, Tu J, Ross J, et al. Use of ezetimibe in the United States and Canada. N Engl J Med 2008;358. DOI: 10.1056/NEJMoa0801461.
2. Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358:1431-43.
3. Bots Ml, Baldassarre D, Simon A, et al. Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? Eur Heart J 2007;28:398-406.
4. Hodis HN, Mack WJ, LaBree L,et al.The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 1998;128:262-9.
5. Brown BG, Taylor AJ. Doses ENHANCE diminish confidence in LDL lowering or in ezetimibe? N Engl J Med 2008;358: 1504-7.
6. During A, Dawson HD, Harrision EH. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1,and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr 2005;135:2305-12.
7. Drazen JM, Jarcho JA, Morrissey S, Curfmans GD. Cholesterol lowering and Ezetimibe. N Eng J Med 358;1507:2008.
8. American College of Cardiology statement on ENHANCE trial. January 15, 2008. (Accessed March 13, 2008, at http://www.acc.org/enhance.htm.)