Gardos pathway to sickle cell therapies?

Blood

Volumn 111, Issue 8, 2008, Pages 3918-3919

  Joiner, Clinton H ^a  

^a Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; HEMOGLOBIN; SENICAPOC; UNCLASSIFIED DRUG;

CELL COUNT; DRUG TOLERABILITY; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; NONHUMAN; NOTE; PRIORITY JOURNAL; SICKLE CELL ANEMIA; TREATMENT RESPONSE;

EID: 50849134271     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-01-135350     Document Type: Note

References (9)

1. Gardos G. The function of calcium in the potassium permeability of human erythrocytes. Biochim Biophys Acta. 1958;30:653-654.
2. Tosteson D, Shea E, Darling RC. Potassium and sodium in red blood cells in sickle cell anemia. J Clin Invest. 1952;48:406-411.
3. Joiner C, Rettig RK, JiangM,RisingerM,Franco PS. Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes. Blood. 2007;109:1728-1735.
4. Lew VL, Etzion Z, Bookchin RM. Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization. Blood. 2002;99:2578-2585.
5. Brugnara C, de Franceschi L, Alper SL. Inhibition of Ca(2+)-dependentK- transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives [see comment]. J Clin Invest. 1993;92:520-526.
6. Icagen, Inc. Press Release. Business Wire. April 3, 2007.
7. Serjeant GR, Serjeant BE, Milner PF. The irreversibly sickled cell; a determinant of haemolysis in sickle cell anaemia. Br J Haematol. 1969;17:527-533.
8. Ballas SK. Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells.AmJ Hematol. 1991;36:122-130.
9. KatoGJ,GladwinMT,SteinbergMH.Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the developmentof clinical subphenotypes.BloodRev. 2007;21:37-47.