Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells

Journal of Periodontal Research

Volumn 43, Issue 5, 2008, Pages 508-513

  Kishimoto, A ^a   Fujita, T ^a   Shiba, H ^a   Komatsuzawa, H ^a   Takeda, K ^a   Kajiya, M ^a   Hayashida, K ^a   Kawaguchi, H ^a   Kurihara, H ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

A. acitinomycetemcomitans; ERK pathway; Gingival epithelial cells; IL 8; Irsogladine maleate; OMP29

Indexed keywords

INTERLEUKIN 8; IRSOGLADINE; MITOGEN ACTIVATED PROTEIN KINASE; OMP29 PROTEIN, ACTINOBACILLUS ACTINOMYCETEMCOMITANS; OUTER MEMBRANE PROTEIN; PROTEIN KINASE INHIBITOR; TRIAZINE DERIVATIVE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ARTICLE; BIOSYNTHESIS; BLOOD; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; GINGIVA; HUMAN; IMMUNOLOGY; MICROBIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; BACTERIAL OUTER MEMBRANE PROTEINS; CELLS, CULTURED; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GINGIVA; HUMANS; INTERLEUKIN-8; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; TRIAZINES;

EID: 50849116119     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2007.01059.x     Document Type: Article

References (24)

1. Uchida Y, Shiba H, Komatsuzawa H et al. Expression of IL-1β and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Cytokine 2001 14 : 152 161.
2. Katz J, Sambandam V, Wu JH, Michalek SM, Balkovetz DF. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infect Immun 2000 68 : 1441 1449.
3. Noguchi T, Shiba H, Komatsuzawa H et al. Syntheses of prostaglandin E2 and E-cadherin and gene expression of β-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Inflammation 2003 27 : 341 349.
4. Uchida Y, Shiba H, Komatsuzawa H et al. Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge. Biochem Biophys Res Commun 2005 333 : 502 507.
5. Fujita T, Ashikaga A, Shiba H et al. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans- induced reduction of gap-junctional intercellular communication. Cytokine 2006 34 : 271 277.
6. Saez JC, Gregory WA, Watanabe T et al. cAMP delays disappearance of gap junctions between pairs of rat hepatocytes in primary culture. Am J Physiol Cell Physiol 1989 257 : C1 C11.
7. Kawasaki Y, Tsuchida A, Sasaki T et al. Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas 2002 25 : 373 377.
8. Ueda F, Kyoi T, Mimura K, Kimura K, Yamamoto M. Intercellular communication in cultured rabbit gastric epithelial cells. Jpn J Pharmacol 1991 57 : 321 328.
9. Nakashima Y, Kohno H, El-Assal ON, Dhar DK, Ueda F, Nagasue N. Irsogladine upregulates expressions of connexin32 and connexin26 in the rat liver. Hepatol Res 2000 18 : 29 42.
10. 1 integrin in oral keratinocytes. J Biol Chem 2000 275 : 23869 23876.
11. Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human β-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-κB transcription factor family. J Immunol 2002 168 : 316 324.
12. Saklatvala J, Rawlinson LM, Marshall CJ, Kracht M. Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. FEBS Lett 1993 334 : 189 192.
13. Derijard B, Raingeaud J, Barrett T et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995 267 : 682 685.
14. Komatsuzawa H, Asakawa R, Kawai T et al. Identification of six major outer membrane proteins from Actinobacillus actinomycetemcomitans. Gene 2002 288 : 195 201.
15. Ouhara K, Komatsuzawa H, Shiba H et al. Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of β-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells. Infect Immun 2006 74 : 5211 5220.
16. Zhang L, Pelech SL, Mayrand D, Grenier D, Heino J, Uitto VJ. Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases. Exp Cell Res 2001 266 : 11 20.
17. Abdel-Latif MM, Windle H, Terres A, Eidhin DN, Kelleher D, Reynolds JV. Helicobacter pylori extract induces nuclear factor- κB, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. J Gastrointest Surg 2006 10 : 551 562.
18. Kim SY, Lee YC, Kim HK, Blaser MJ. Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol 2006 8 : 97 106.
19. Nozawa Y, Nishihara K, Peek RM et al. Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem Pharmacol 2002 64 : 21 30.
20. Yamada H, Aihara T, Okabe S. Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): roles of mitogen-activated protein kinase and interleukin-1β. Biochem Pharmacol 2001 61 : 1595 1604.
21. Torok AM, Bouton AH, Goldberg JB. Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun 2005 73 : 1523 1531.
22. Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V. MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases. J Biol Chem 2002 277 : 32490 32497.
23. Takahashi H, Honma M, Miyauchi Y, Nakamura S, Ishida-Yamamoto A, Iizuka H. Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf. Arch Dermatol Res 2004 296 : 74 82.
24. Yamaguchi T, Nagao S, Wallace DP et al. Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int 2003 63 : 1983 1994.