Enantiomeric reversed-phase high-performance liquid chromatography resolution of d-/l-penicillamine after spirocyclization with ninhydrin and by using copper(II)-l-proline complex as a chiral selector in the mobile phase

Journal of Chromatography A

Volumn 1205, Issue 1-2, 2008, Pages 90-93

  Sotgia, Salvatore ^a   Zinellu, Angelo ^a,b   Pisanu, Elisabetta ^a   Pinna, Gerard Aime ^a   Deiana, Luca ^a   Carru, Ciriaco ^a,b  

^a UNIVERSITY OF SASSARI   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

Chiral ligand exchange chromatography; Chirality; Derivatization; Ninhydrin; Penicillamine; Spirothiazolidine

Indexed keywords

CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; COPPER; COPPER COMPOUNDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERS; LIQUID CHROMATOGRAPHY; LIQUID PHASE EPITAXY; SEPARATION; STEREOCHEMISTRY; SULFUR COMPOUNDS;

ABSORBANCE DETECTION; C18 COLUMN; CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY; CHIRAL SELECTORS; CHIRALITY; COPPER(II); DERIVATIZATION; HPLC METHODS; ISOCRATIC ELUTION; L-PROLINE; MOBILE PHASE; NINHYDRIN; PENICILLAMINE; REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; SPIROCYCLIZATION; SPIROTHIAZOLIDINE;

PHASE SEPARATION;

COPPER; NINHYDRIN; PENICILLAMINE; PROLINE;

ARTICLE; CHIRALITY; COMPLEX FORMATION; CYCLIZATION; DRUG DETERMINATION; DRUG PURIFICATION; DRUG STRUCTURE; ELUTION; ENANTIOMER; PRIORITY JOURNAL; RACEMIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOISOMERISM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; NINHYDRIN; PENICILLAMINE; PROLINE; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 50849110793     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.08.021     Document Type: Article

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