Gadofluorine M enhancement allows more sensitive detection of inflammatory CNS lesions than T2-w imaging: A quantitative MRI study

Brain

Volumn 131, Issue 9, 2008, Pages 2341-2352

  Bendszus, Martin ^a,b   Ladewig, Gesa ^a   Jestaedt, Leonie ^a,b   Misselwitz, Bernd ^c   Solymosi, Laszlo ^a   Toyka, Klaus ^a   Stoll, Guido ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c BAYER PHARMA AG   (Germany)

Author keywords

CNS inflammation; Experimental autoimmune encephalomyelitis; Gadofluorine; Magnetic resonance imaging; Multiple sclerosis

Indexed keywords

GADOFLUORINE M; GADOLINIUM PENTETATE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CENTRAL NERVOUS SYSTEM; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DEMYELINATION; DIAGNOSTIC ACCURACY; ENCEPHALITIS; FEMALE; INTERMETHOD COMPARISON; MULTIPLE SCLEROSIS; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE LESION; PRIORITY JOURNAL; QUANTITATIVE STUDY; RAT; SENSITIVITY AND SPECIFICITY; SPINAL CORD LESION;

EID: 50849091554     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awn156     Document Type: Article

References (26)

1. Barkhausen J, Ebert W, Heyer C, Debatin JF, Weinmann HJ. Detection of atherosclerotic plaque with Gadofluorine-enhanced magnetic resonance imaging. Circulation 2003; 108: 605-9.
2. Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997; 120: 2059-69.
3. Bendszus M, Kleinschnitz C, Stoll G. Iron-enhanced MRI in ischemic stroke: intravascular trapping versus cellular inflammation. Stroke 2007; 38: e12.
4. Bendszus M, Stoll G. Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging. J Neurosci 2003; 23: 10892-6.
5. Bendszus M, Wessig C, Schütz A, Horn T, Kleinschnitz C, Sommer C, et al. Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging. Ann Neurol 2005; 57: 388-95.
6. Bergers E, Bot JC, De Groot CJ, Polman CH, Lycklama à Nijeholt GJ, Castelijns JA, et al. Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions. Neurology 2002; 59: 1766-71.
7. Brochet B, Deloire MS, Touil T, Anne O, CaillÃc JM, Dousset V, et al. Early macrophage MRI of inflammatory lesions predicts lesion severity and disease development in relapsing EAE. Neuroimage 2006; 32: 266-74.
8. Comi G, Filippi M, Barkhof F, Durelli L, Edan G, Fernandez O, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 2001; 357: 1576-82.
9. Devaux B, Enderlin F, Wallner B, Smilek DE. Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide. J Neuroimmunol 1997; 75: 169-73.
10. Dousset V, Brochet B, Deloire MS, Lagoarde L, Barroso B, Caille JM, et al. MR imaging of relapsing multiple sclerosis patients using ultra-small-particle iron oxide and compared with gadolinium. Am J Neuroradiol 2006; 27: 1000-5.
11. Filippi M, Grossmann RI. MRI techniques to monitor MS evolution: the present and the future. Neurology 2002; 58: 1147-53.
12. Henning TD, Saborowski O, Golovko D, Boddington S, Bauer JS, Fu Y, et al. Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol 2007; 17: 1226-34.
13. Hilton AA, Slavin AJ, Hilton DJ, Bernard CC. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. J Neurochem 1995; 65: 309-18.
14. Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 2000; 343: 898-904.
15. Kangarlu A, Bourekas EC, Ray-Chaudhury A, Rammohan KW. Cerebral cortical lesions in multiple sclerosis detected by MR imaging at 8 Tesla. Am J Neuroradiol 2007; 28: 262-6.
16. Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, Miller DH, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology 2006; 67: 1242-9.
17. Kleinschnitz C, Bendszus M, Frank M, Solymosi L, Toyka KV, Stoll G. In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging. J Cereb Blood Flow Metabol 2003; 23: 1356-61.
18. Madri JA, Graesser D. Cell migration in the immune system: the evolving inter-related roles of adhesion molecules and proteinases. Dev Immunol 2000; 7: 103-16.
19. Meding J, Urich M, Licha K, Reinhardt M, Misselwitz B, Fayad ZA, et al. Magnetic resonance imaging of atherosclerosis by targeting extracellulr matrix deposition with Gadofluorine M. Contrast Media Mol Imaging 2007; 2: 120-29.
20. Misselwitz B, Platzek J, Weinmann HJ. Early MR lymphography with gadofluorine M in rabbits. Radiology 2004; 231: 682-8.
21. Naparstek Y, Cohen IR, Fuks Z, Vlodavsky I. Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase. Nature 1984; 310: 241-4.
22. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005; 58: 840-6.
23. Pouwels PJ, Kuijer JP, Mugler JP 3rd, Guttmann CR, Barkhof F. Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging. Radiology 2006; 241: 873-9.
24. Rocca MA, Hickman SJ, Bö L, Agosta F, Miller DH, Comi G, et al. Imaging the optic nerve in multiple sclerosis. Mult Scler 2005; 11: 537-41.
25. Storch MK, Stefferl A, Brehm U, Weissert R, Wallstrom E, Kerschensteiner M, et al. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol 1998; 8: 681-94.
26. Vellinga MM, Oude Engberink RD, Seewann A, Pouwels PJ, Wattjes MP, van der Pol SM, et al. Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement. Brain 2008; 131: 800-7.