Microfluidic mixing via transverse electrokinetic effects in a planar microchannel

Microfluidics and Nanofluidics

Volumn 5, Issue 4, 2008, Pages 493-505

  Lynn, N Scott ^a   Henry, Charles S ^b   Dandy, David S ^a  

^a Engineering Research Center and Hydraulics Laboratory   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Electro osmosis; Integrated electrodes; Micro mixing; PDMS

Indexed keywords

ELECTRIC FIELD EFFECTS; ELECTRIC FIELDS; ELECTROMAGNETIC FIELD THEORY; ELECTROMAGNETIC FIELDS; ELECTROOSMOSIS; FLOW OF FLUIDS; MICROCHANNELS; MIXING; NANOFLUIDICS; NUMERICAL METHODS; THREE DIMENSIONAL;

CHANNEL WALLS; CONDITIONAL ENTROPY; ELECTRO-OSMOTIC FLOW; ELECTROKINETIC EFFECTS; HELICAL MOTION; INTEGRATED ELECTRODES; MICRO MIXERS; MICRO-FLUIDIC MIXING; MICRO-MIXING; NUMERICAL MODELLING; PARTICLE TRACKING; PASSIVE TRACER PARTICLES; PDMS; THREE-DIMENSIONAL FLOW FIELDS; TRANSVERSE DIRECTION;

ELECTRIC DRIVES;

EID: 50649124904     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-008-0258-8     Document Type: Article

References (53)

1. Altas I, Dym J, Gupta MM, Manohar RP (1998) Multigrid solution of automatically generated high-order discretizations for the biharmonic equation. SIAM J Sci Comput 19:1575-1585
2. Anderson JL (1989) Colloid Transport by Interfacial Forces. Annu Rev Fluid Mech 21:61-99
3. Bhattacharya S, Datta A, Berg JM, Gangopadhyay S (2005) Studies on surface wettability of poly(dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength. J Microelectromech Syst 14:590-597
4. Biddiss E, Erickson D, Li DQ (2004) Heterogeneous surface charge enhanced micromixing for electrokinetic flows. Anal Chem 76:3208-3213
5. Camesasca M, Manas-Zloczower I, Kaufman M (2005) Entropic characterization of mixing in microchannels. J Micromech Microeng 15:2038-2044
6. Camesasca M, Kaufman M, Manas-Zloczower I (2006) Quantifying fluid mixing with the Shannon entropy. Macromol Theory Simul 15:595-607
7. Cha J, Kim J, Ryu SK, Park J, Jeong Y, Park S, Park S, Kim HC, Chun K (2006) A highly efficient 3D micromixer using soft PDMS bonding. J Micromech Microeng 16:1778-1782
8. Chang CC, Yang RJ (2004) Computational analysis of electrokinetically driven flow mixing in microchannels with patterned blocks. J Micromech Microeng 14:550-558
9. Chang CC, Yang RJ (2006) A particle tracking method for analyzing chaotic electroosmotic flow mixing in 3D microchannels with patterned charged surfaces. J Micromech Microeng 16:1453-1462
10. Chang CC, Yang RJ (2007) Electrokinetic mixing in microfluidic systems. Microfluidics Nanofluidics 3:501-525
11. Chen H, Meiners JC (2004) Topologic mixing on a microfluidic chip. Appl Phys Lett 84:2193-2195
12. Dodge A, Jullien MC, Lee YK, Niu X, Okkels F, Tabeling P (2004) An example of a chaotic micromixer: The cross-channel micromixer. C R Phys 5:557-563
13. Gitlin I, Stroock AD, Whitesides GM, Ajdari A (2003) Pumping based on transverse electrokinetic effects. Appl Phys Lett 83:1486-1488
14. Hunter RJ (1981) Zeta potential in colloid science. Academic Press, New York
15. Jiang F, Drese KS, Hardt S, Kupper M, Schonfeld F (2004) Helical flows and chaotic mixing in curved micro channels. Aiche J 50:2297-2305
16. Johnson TJ, Locascio LE (2002) Characterization and optimization of slanted well designs for microfluidic mixing under electroosmotic flow. Lab Chip 2:135-140
17. Kim DS, Lee SW, Kwon TH, Lee SS (2004) A barrier embedded chaotic micromixer. J Micromech Microeng 14:798-805
18. Lammertink RGH, Schlautmann S, Besselink GAJ, Schasfoort RBM (2004) Recirculation of nanoliter volumes within microfluidic channels. Anal Chem 76:3018-3022
19. Lee JN, Park C, Whitesides GM (2003) Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal Chem 75:6544-6554
20. Lee CY, Lee GB, Fu LM, Lee KH, Yang RJ (2004) Electrokinetically driven active micro-mixers utilizing zeta potential variation induced by field effect. J Micromech Microeng 14:1390-1398
21. Leu TS, Ma FC (2005) Novel EHD-pump driven micro mixers. J Mech 21:137-144
22. Lin H, Storey BD, Oddy MH, Chen CH, Santiago JG (2004) Instability of electrokinetic microchannel flows with conductivity gradients. Phys Fluids 16:1922-1935
23. Lin JL, Lee KH, Lee GB (2005) Active mixing inside microchannels utilizing dynamic variation of gradient zeta potentials. Electrophoresis 26:4605-4615
24. McKnight TE, Culbertson CT, Jacobson SC, Ramsey JM (2001) Electroosmotically induced hydraulic pumping with integrated electrodes on microfluidic devices. Anal Chem 73:4045-4049
25. Meleshko VV (1998) Biharmonic problem in a rectangle. Appl Sci Res 58:217-249
26. Munson MS, Yager P (2004) Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer. Analytica Chimica Acta 507:63-71
27. Neils C, Tyree Z, Finlayson B, Folch A (2004) Combinatorial mixing of microfluidic streams. Lab Chip 4:342-350
28. Niu XZ, Lee YK (2003) Efficient spatial-temporal chaotic mixing in microchannels. J Micromech Microeng 13:454-462
29. Niu XZ, Liu LY, Wen WJ and Sheng P (2006) Hybrid approach to high-frequency microfluidic mixing. Phys Rev Lett 97
30. Oddy MH, Santiago JG, Mikkelsen JC (2001) Electrokinetic instability micromixing. Anal Chem 73:5822-5832
31. Pacheco JR, Chen KP, Hayes MA (2006) Rapid and efficient mixing in a slip-driven three-dimensional flow in a rectangular channel. Fluid Dyn Res 38:503-521
32. Park J, Shin SM, Huh KY and Kang IS (2005) Application of electrokinetic instability for enhanced mixing in various micro-T-channel geometries. Phys Fluids 17
33. Qian SZ, Bau HH (2002) A chaotic electroosmotic stirrer. Anal Chem 74:3616-3625
34. Qian SZ, Bau HH (2005) Theoretical investigation of electro-osmotic flows and chaotic stirring in rectangular cavities. Appl Math Model 29:726-753
35. Sato H, Ito S, Tajima K, Orimoto N, Shoji S (2005) PDMS microchannels with slanted grooves embedded in three walls to realize efficient spiral flow. Sens Actuators A Phys 119:365-371
36. Schonfeld F, Hardt S (2004) Simulation of helical flows in microchannels. Aiche J 50:771-778
37. Selverov KP, Stone HA (2001) Peristaltically driven channel flows with applications toward micromixing. Physics of Fluids 13:1837-1859
38. Stone ZB, Stone HA (2005) Imaging and quantifying mixing in a model droplet micromixer. Phys Fluids 17
39. Stone HA, Stroock AD, Ajdari A (2004) Engineering flows in small devices: Microfluidics toward a lab-on-a-chip. Annu Rev Fluid Mech 36:381-411
40. Stroock AD, Dertinger SK, Whitesides GM, Ajdari A (2002a) Patterning flows using grooved surfaces. Anal Chem 74:5306-5312
41. Stroock AD, Dertinger SKW, Ajdari A, Mezic I, Stone HA, Whitesides GM (2002b) Chaotic mixer for microchannels. Science 295:647-651
42. Sundaram N, Tafti DK (2004) Evaluation of microchamber geometries and surface conditions for electrokinetic driven mixing. Anal Chem 76:3785-3793
43. Sudarsan AP, Ugaz VM (2006) Fluid mixing in planar spiral microchannels. Lab Chip 6:74-82
44. Suzuki H, Ho CM, Kasagi N (2004) A chaotic mixer for magnetic bead-based micro cell sorter. J Microelectromech Syst 13:779-790
45. Sze A, Erickson D, Ren LQ, Li DQ (2003) Zeta-potential measurement using the Smoluchowski equation and the slope of the current-time relationship in electroosmotic flow. J Colloid Interface Sci 261:402-410
46. Therriault D, White SR, Lewis JA (2003) Chaotic mixing in three-dimensioned microvascular networks fabricated by direct-write assembly (vol 2, pg 265, 2002). Nat Mater 2:347-347
47. Vickers JA, Caulum MM, Henry CS (2006) Generation of hydrophilic poly(dimethylsiloxane) for high-performance microchip electrophoresis. Anal Chem 78:7446-7452
48. West J, Gleeson JP, Alderman J, Collins JK, Berney H (2003) Structuring laminar flows using annular magnetohydrodynamic actuation. Sens Actuators B Chem 96:190-199
49. Wu HY, Liu CH (2005) A novel electrokinetic micromixer. Sens Actuators A Phys 118:107-115
50. Xia YN, Whitesides GM (1998) Soft lithography. Annu Rev Mater Sci 28:153-184
51. Yamaguchi Y, Takagi F, Watari T, Yamashita K, Nakamura H, Shimizu H, Maeda H (2004a) Interface configuration of the two layered laminar flow in a curved microchannel. Chem Eng J 101:367-372
52. Yamaguchi Y, Takagi F, Yamashita K, Nakamura H, Maeda H, Sotowa K, Kusakabe K, Yamasaki Y, Morooka S (2004b) 3-D simulation and visualization of laminar flow in a microchannel with hair-pin curves. Aiche J 50:1530-1535
53. Yang JT, Huang KJ, Lin YC (2005) Geometric effects on fluid mixing in passive grooved micromixers. Lab Chip 5:1140-1147