The level of aryl acylamidase activity displayed by human butyrylcholinesterase depends on its molecular distribution

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 336-339

  Montenegro, M F ^a,b   Moral Naranjo, M T ^a   Paez de la Cadena M ^b   Campoy, F J ^a   Munoz Delgado E ^a   Vidal, C J ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF VIGO   (Spain)

Author keywords

Aryl acylamidase; Blood serum; Butyrylcholinesterase; Colon; Human; Molecular forms

Indexed keywords

2 NITROACETANILIDE; ACETANILIDE DERIVATIVE; ACETYLCHOLINESTERASE; AMIDASE; ARYL ACYLAMIDASE; CHOLINESTERASE; ESTERASE; MONOMER; NITRO DERIVATIVE; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; HUMAN; HUMAN TISSUE; HYDROLYSIS; OLIGOMERIZATION; PROTEIN PROCESSING;

AMINO ACID NAPHTHYLAMIDASES; BUTYRYLCHOLINESTERASE; COLON; COLORECTAL NEOPLASMS; HUMANS; RECTUM;

EID: 50649121395     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.03.007     Document Type: Article

References (5)

1. Checler F., Grassi J., and Vincent J.P. Cholinesterases display genuine arylacylamidase activity but are totally devoid of intrinsic peptidase activities. J. Neurochem. 62 (1994) 756-763
2. Massoulié J., Bon S., Perrier N., and Falasca C. The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring. Chem. Biol. Interact. 157-158 (2005) 3-14
3. Montenegro M.F., Ruiz-Espejo F., Campoy F.J., Muñoz-Delgado E., Páez de la Cadena M., Rodríguez-Berrocal F.J., and Vidal C.J. Cholinesterases are down-expressed in human colorectal carcinoma. Cell. Mol. Life Sci. 63 (2006) 2175-2182
4. Ruiz-Espejo F., Cabezas-Herrera J., Illana J., Campoy F.J., and Vidal C.J. Cholinesterase activity and acetylcholinesterase glycosylation are altered in human breast cancer. Breast Cancer Res. Treat. 72 (2002) 11-22
5. S. Darvesh, S. McDonald R, K.V. Darvesh, D. Mataija, S. Mothana, H. Cook, K.M. Carneiro, N. Richard, R. Walsh, E. Martin, On the active site for the hydrolysis of aryl amides and choline esters by human cholinesterases, Bioorg. Med. Chem. 14 (2006) 4586-4599.