Cytotoxic effects of haplamine and its major metabolites on human cancer cell lines

Planta Medica

Volumn 74, Issue 10, 2008, Pages 1265-1268

  Ea, Sompheary ^a   Giacometti, Sarah ^a   Ciccolini, Joseph ^a   Akhmedjanova, Valentina ^b   Aubert, Claude ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b S Yu Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences   (Uzbekistan)

Author keywords

Cancer cell lines; Cytotoxicity; Haplamine; Hapophyllum perforatum; Rutaceae; Trans cis 3,4 dihydroxyhaplamine

Indexed keywords

3,4 DIHYDROXYHAPLAMINE; FLUOROPYRIMIDINE; FLUOROURACIL; GEMCITABINE; HAPLAMINE; PLANT EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DIGESTIVE SYSTEM CANCER; DRUG EFFICACY; DRUG POTENCY; HAPLOPHYLLUM PERFORATUM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER; MEDICINAL PLANT; METABOLITE; PANCREAS CANCER; PANCREAS CELL; STUDENT T TEST;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; DIGESTIVE SYSTEM NEOPLASMS; FLUOROURACIL; HUMANS; PYRANS; QUINOLONES; RUTACEAE;

HAPLOPHYLLUM; RUTACEAE;

EID: 50649118646     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081298     Document Type: Article

References (13)

1. Khalmatov KH. Wild medicinal plants of Uzbekistan, Tashkent. Medistsina; 1964: 134-5
2. Akhmedkhodzhaeva KHS, Kurmukov AG. Pharmacology of haplamine. Dokl Akad Nauk UzSSR 1975; 8: 36
3. Venturella P, Bellino A, Piozzi F. Synthesis of haplamine. Heterocycles 1975; 3: 367-70
4. Jansen O, Akhmedjanova V, Angenot L, Balansard G, Chariot A, Ollivier E et al. Screening of 14 alkaloids isolated from Haplophyllum A. Juss for their cytotoxic properties. J Ethnopharmacol 2006; 105: 241-5
5. Ea S, Bun SS, Aubert C, Akhmedjanova V, Ollivier E, Siv C et al. Inter-species variability of haplamine metabolism and identification of its phase I metabolites from liver microsomes. Planta Med 2006; 72: 1273-8
6. Ea S, Aubert C, Giacometti S, Ciccolini J, Siv C, Bun H. Validation of a simple HPLC method for haplamine and its metabolites assay in plasma suitable for pharmacokinetic application in rats. Biomed Chromatogr 2008; 22: 125-30
7. Akhmedjanova VI, Bessonova IA, Yunusov SY. Alkaloids of Haplophyllum perforatum. Khim Prirod Soed 1976; 3: 320-8
8. Shakirov R, Telezhenetskaya MV, Bessonova IA, Aripova SF, Israilov IA, Sulankhodjaev MN et al. The alkaloids plants structure and properties. Khim Prirod Soed 1996; 1: 118-89
9. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988; 48: 589-601
10. Fanciullino R, Giacometti S, Aubert C, Fina F, Martin PM, Piccerelle P et al. Development of stealth liposome formulation of 2′-deoxyinosine as 5-fluorouracil modulator: in vitro and in vivo study. Pharm Res 2005; 22: 2051-7
11. Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003; 3: 330-8
12. Mulcahy MF. Adjuvant therapy for pancreas cancer: advances and controversies. Semin Oncol 2007; 34: 321-6
13. Ciccolini J, Fina F, Bezulier K, Giacometti S, Roussel M, Evrard A et al. Transmission of apoptosis in human colorectal tumor cells exposed to capecitabine, Xeloda, is mediated via Fas. Mol Cancer Ther 2002; 11: 923-7