Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 305-308

  Čalić, Maja ^a   Bosak, Anita ^a   Kuča, Kamil ^b   Kovarik, Zrinka ^a  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Nerve agents; Oxime; Protection; Reactivation

Indexed keywords

2 BUTENE; ALDOXIME; BUTANE; CHOLINESTERASE; PHOSPHORUS DERIVATIVE; PYRIDINIUM DERIVATIVE; SERINE; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG; XYLENE;

ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HUMAN;

BUTANES; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; HUMANS; KINETICS; OXIMES; PHOSPHORIC ACID ESTERS;

EID: 50649097918     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.04.010     Document Type: Article

References (12)

1. Dawson R.M. Review of oximes available for the treatment of nerve agent poisoning. J. Appl. Toxicol. 14 (1994) 317-331
2. Pang Y.-P., Kollmeyer T.M., Hong F., Lee J., Hammond P.I., Haugabouk S.P., and Brimijoin S. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem. Biol. 10 (2003) 491-502
3. Kovarik Z., Radić Z., Berman H.A., Simeon-Rudolf V., Reiner E., and Taylor P. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphorylated conjugates. Biochemistry 43 (2004) 3222-3229
4. Kovarik Z., Čalić M., Šinko G., and Bosak A. Structure-activity approach in the reactivation of tabun-phosphorylated human acetylcholinesterase with bispyridinium para-aldoximes. Arh. Hig. Rada Toksikol. 58 (2007) 201-209
5. Lenz D.E., Yeung D., Smith J.R., Sweeney R.E., Lumley L.A., and Cerasoli D.M. Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review. Toxicology 233 (2007) 31-39
6. Lucić Vrdoljak A., Čalić M., Radić B., Berend S., Jun D., Kuča K., and Kovarik Z. Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning. Toxicology 228 (2006) 41-50
7. Eto M. Organophosphorus Pesticides: Organic and Biological Chemistry (1976), CRC Press Inc., Cleveland p. 142
8. Čalić M., Lucić Vrdoljak A., Radić B., Jelić D., Jun D., Kuča K., and Kovarik Z. In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity. Toxicology 219 (2006) 85-96
9. Kovarik Z., Čalić M., Bosak A., Šinko G., and Jelić D. In vitro evaluation of aldoxime interactions with human acetylcholinesterase. Croat. Chem. Acta 81 (2008) 47-57
10. Šinko G., Čalić M., and Kovarik Z. para- and ortho-Pyridinium aldoximes in reaction with acetylthiocholine. FEBS Lett. 580 (2006) 3167-3172
11. Šinko G., Čalić M., Bosak A., and Kovarik Z. Limitation of the Ellman method: cholinesterase activity measurement in the presence of oximes. Anal. Biochem. 370 (2007) 223-227
12. Kuča K., Jun D., and Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev. Med. Chem. 6 (2006) 269-277