Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 2, 2008, Pages 388-397

  Mészáros, Gabriella Pásztor ^a   Ágai Csongor, Éva ^a   Kapás, Margit ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

Desmethyl RGH 188; Didesmethyl RGH 188; Human plasma and urine; LC MS MS; RGH 188

Indexed keywords

4 [2 [4 (2,3 DICHLOROPHENYL)PIPERAZINE 1 YL]ETHYL] N,N DIMETHYLCARBAMOYLCYCLOHEXYLAMINE; ATYPICAL ANTIPSYCHOTIC AGENT; DINOR 4 [2 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] N,N DIMETHYLCARBAMOYLCYCLOHEXYLAMINE; DRUG METABOLITE; NOR 4 [2 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] N,N DIMETHYLCARBAMOYLCYCLOHEXYLAMINE; RGH 188; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; DILUTION; DRUG BLOOD LEVEL; DRUG URINE LEVEL; FREEZE THAWING; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANTIPSYCHOTIC AGENTS; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; PIPERAZINES; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 50649097483     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.12.016     Document Type: Article

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