Using modeling to explore the degree to which a microbicide's sexually transmitted infection efficacy may contribute to the HIV effectiveness measured in phase 3 microbicide trials

Journal of Acquired Immune Deficiency Syndromes

Volumn 48, Issue 4, 2008, Pages 460-467

  Vickerman, Peter ^a   Foss, Anna ^a   Watts, Charlotte ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

HIV; Microbicides; Sexually transmitted infections; Trial effectiveness

Indexed keywords

MICROBICIDE; ANTIINFECTIVE AGENT; ANTIRETROVIRUS AGENT;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; MALE; MATHEMATICAL MODEL; OUTCOME ASSESSMENT; PHASE 3 CLINICAL TRIAL; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEXUALLY TRANSMITTED DISEASE; VIRUS TRANSMISSION; COMPUTER SIMULATION; DISEASE TRANSMISSION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; SEXUAL BEHAVIOR; STATISTICAL MODEL; THEORETICAL MODEL;

ANTI-INFECTIVE AGENTS; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DISEASE TRANSMISSION, HORIZONTAL; FEMALE; GELS; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; MODELS, STATISTICAL; MODELS, THEORETICAL; SEXUAL BEHAVIOR;

EID: 50649094760     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31817aebd6     Document Type: Article

References (16)

1. Balzarini J, Van Damme L. Microbicide drug candidates to prevent HIV infection. Lancet. 2007;369:787-797.
2. Zeitlin L, Whaley KJ. Microbicides for preventing transmission of genital herpes. Herpes. 2002;9:4-9.
3. Bowcut J. Microbicide activity against non-HIV pathogens. Microbicide Q. 2003;1:5-7. Available at: www.microbicide.com/publications/quarterly. shtml. Accessed October 2007.
4. Rottingen J, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV. Sex Transm Dis. 2001;28:579-595.
5. Grosskurth H, Mosha F, Todd J, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet. 1995;346:530-536.
6. Desai K, Boily MC, Garnett GP, et al. The role of sexually transmitted infections in male circumcision effectiveness against HIV - insights from clinical trial simulation. Emerg Themes Epidemiol. 2006;3:19.
7. Delany S, Moyes J, Pascoe S, et al. Sexually transmitted infections may play an important role in mediating the effect of microbicides in Phase III trials. Paper presented at: Microbicides, April 23-26, 2006; Cape Town, South Africa.
8. Vickerman P, Terris-Prestholt F, Delaney S, et al. Are targeted HIV prevention activities still cost-effective in high prevalence settings? Results from an STI treatment intervention for sex-workers in Hillbrow, South Africa. Sex Transm Dis. 2006;33(Suppl):S122-S132.
9. Kaul R, Kimani J, Nagelkerke N, et al. Monthly antibiotic chemopro-phylaxis and incidence of sexually transmitted infections and HIV-1 infections in Kenyan sex workers. JAMA. 2004;291:2555-2562.
10. Auvert B, Taljaard D, Lagarde E, et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2:e298.
11. Wawer MJ, Sewankambo NK, Serwadda D, et al. Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group. Lancet. 1999;353: 525-535.
12. Weiss H. Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes. 2004;11(Suppl 1):24A-35A.
13. Holmes KK, Johnson DW, Trostle HJ. An estimate of the risk of men acquiring gonorrhea by sexual contact with infected females. Am J Epidemiol. 1970;91:170-174.
14. Mann JR, Stine CC, Vessey J. The role of disease-specific infectivity and number of disease exposures on long-term effectiveness of the latex condom. Sex Transm Dis. 2002;29:344-349.
15. Garnett GP, Aral SO, Hoyle DV, et al. The natural history of syphilis. Implications for the transmission dynamics and control of infection. Sex Transm Dis. 1997;24:185-200.
16. Korenromp EL, Iudaryo MK, de Vlas SJ, et al. What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic? Int J STD AIDS. 2002;13:91-101.