Bio-distribution study of 1,2-diethylbenzene and its main metabolites by whole-body autoradiography and tissue homogenates

Archives of Toxicology

Volumn 82, Issue 9, 2008, Pages 591-600

  Payan, Jean Paul ^a   Binet, Stephane ^a   Beydon, Dominique ^a   Ferrari, Elisabeth ^a  

^a INSTITUT NATIONAL DE RECHERCHE ET DE SÉCURITÉ   (France)

Author keywords

1,2 Diethylbenzene; Autoradiography; Distribution; Rat; Toxicokinetics

Indexed keywords

1 (2' ETHYLPHENYL)ETHANOL; 1,2 DIETHYLBENZENE; ALCOHOL; BENZENE DERIVATIVE; CARBON 14; DRUG METABOLITE; NEUROTOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD CELL; BRAIN; BRAIN CELL; BRAIN HOMOGENATE; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; KIDNEY; LIVER METABOLISM; LUNG; MALE; METABOLITE; NEUROTOXICITY; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; RAT; SPINAL CORD; TISSUE DISTRIBUTION; TISSUE HOMOGENATE; TOXICOKINETICS; TURBINATE; WHOLE BODY AUTORADIOGRAPHY;

ALGORITHMS; ANIMALS; AUTORADIOGRAPHY; BENZENE DERIVATIVES; BLOOD CELLS; BRAIN; HALF-LIFE; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 50649088413     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0281-2     Document Type: Article

References (20)

1. Arms AD, Travis CC (1988) Reference physiological parameters in pharmacokinetic modeling. EPA/600/6-88/004. U.S. Environmental Protection Agency, Washington, DC
2. RP Brown MD Delp SL Lindstedt LR Rhomberg RP Beliles 1997 Physiological parameter values for physiologically based pharmacokinetic models Toxicol Ind Health 13 407 484
3. Cavender F (1994) Ethylbenzene. In: Clayton GD, Clayton FE (eds) Patty's Industrial Hygiene and Toxicology, vol 2, part B, 4th rev edn. Wiley Interscience, New York, pp 1342-1346
4. F Gagnaire MN Becker B Marignac P Bonnet J De Ceaurriz 1992 Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats J Appl Toxicol 12 335 342
5. F Gagnaire A Ensminger B Marignac J De Ceaurriz 1991 Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats J Appl Toxicol 11 261 268
6. F Gagnaire B Marignac J de Ceaurriz 1990 Diethylbenzene-induced sensorimotor neuropathy in rats J Appl Toxicol 10 105 112
7. Gerarde HW (1960) Biochemistry of the aromatic hydrocarbons. Elsevier, Amsterdam
8. MS Kim MI Sabri VH Miller RJ Kayton DA Dixon PS Spencer 2001 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy Toxicol Appl Pharmacol 177 121 131
9. I Linhart Z Weidenhoffer P Sedmera M Polasekj J Smejkal 1996 Biotransformation of diethenylbenzenes, V. Identification of urinary metabolites of 1,2-diethenylbenzene in the rat Xenobiotica 26 1263 1272
10. G Nong G Charest-Tardif R Tardif DFV Lewis LM Sweeney ML Gargas K Krishnan 2007 Physiologically based modeling of the inhalation pharmacokinetics of ethylbenzene in B6C3F1 mice J Toxicol Environ Health Part A 70 1838 1848
11. JP Payan D Beydon B Cossec A Ensminger JP Fabry E Ferrari 1999 Toxicokinetics of 1,2-diethylbenzene in male Sprague-Dawley rats Part 1: excretion and metabolism of [(14)C]1,2-diethylbenzene Drug Metab Dispos 27 1470 1478
12. JP Payan B Cossec D Beydon JP Fabry E Ferrari 2001 Toxicokinetics and metabolism of 1,2-diethylbenzene in male Sprague Dawley rats Part 2: evidence for in vitro and in vivo stereoselectivity of 1,2-diethylbenzene metabolism Drug Metab Dispos 29 868 876
13. C Riemschneider RaW 1955 Uber die Eignung von 1,2-diacylbenzolen zum Nachweis und zur Bestimmung von Aminosâuren Monastsch Chem 86 201 209
14. Sandmeyer E (1981) Aromatic hydrocarbons. In: CGDaC FE (eds) Patty's industrial hygiene and toxicology. Wiley, New York, pp 3253-3431
15. A Sato T Nakajima 1987 Pharmacokinetics of organic solvent vapors in relation to their toxicity Scand J Work Environ Health 13 81 93
16. Spencer PS (1982) Experimental evaluation of selected petrochemicals for subchronic neurotoxic properties. In: Mc Farland HN, Holdworth CE, Mc Gregor JA, Call RW, Kane ML (eds) Toxicology of petroleum hydrocarbons. American Petroleum Institute, Washington, pp 249-260
17. The 2004 OECD List of High Production Volume Chemicals (2004) OECD Environment Directorate, Paris, p 143
18. S Ullberg 1954 Autoradiographical distribution and excretion studies with S35-labelled penicillin Proc Soc Exp Biol Med 85 550 553
19. P Upadhyaya SG Carmella FP Guengerich SS Hecht 2000 Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues Carcinogenesis 21 1233 1238
20. GR Wilkinson 1987 Clearance approaches in pharmacology Pharmacol Rev 39 1 47