Tolerability and effects of oral Δ9-tetrahydrocannabinol in older adolescents with marijuana use disorders

Pharmacology Biochemistry and Behavior

Volumn 91, Issue 1, 2008, Pages 67-70

  Gray, Kevin M ^a   Hart, Carl L ^b   Christie, Douglas K ^a   Upadhyaya, Himanshu P ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Adolescent; Cannabis; Dronabinol; Marijuana; Oral THC

Indexed keywords

CANNABIS; DRONABINOL;

ADOLESCENT; ADULT; ARTICLE; CANNABIS ADDICTION; CANNABIS SMOKING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIGIT SYMBOL SUBSTITUTION TASK; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; TASK PERFORMANCE;

ADOLESCENT; ADULT; AFFECT; BLOOD PRESSURE; DATA INTERPRETATION, STATISTICAL; EUPHORIA; FEMALE; HALLUCINOGENS; HEART RATE; HUMANS; MALE; MARIJUANA ABUSE; PSYCHOMOTOR PERFORMANCE; TETRAHYDROCANNABINOL;

CANNABIS; CANNABIS SATIVA;

EID: 50649086574     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.06.011     Document Type: Article

References (27)

1. Benowitz N.L., and Jones R.T. Cardiovascular effects of prolonged Delta-9-tetrahydrocannabinol ingestion. Clin Pharmacol Ther 25 (1975) 440-446
2. Benowitz N.L., and Jones R.T. Cardiovascular and metabolic considerations in prolonged cannabinoid administration in man. J Clin Pharmacol 21 (1981) 214S-223S
3. Budney A.J., Vandrey R.G., Hughes J.R., Moore B.A., and Bahrenburg B. Oral delta-9-tetrahydrocannabinol suppresses cannabis withdrawal symptoms. Drug Alcohol Depend 86 (2007) 22-29
4. Budney A.L., Vandrey R.G., Hughes J.R., Thostenson J.D., and Bursac Z. Comparison of cannabis and tobacco withdrawal: severity and contribution to relapse. J Subst Abuse Treat (2008) 10.1016/j.jsat.2008.01.002
5. Calhoun S.R., Galloway G.P., and Smith D.E. Abuse potential of dronabinol (Marinol). J Psychoactive Drugs 30 (1998) 187-196
6. Chen C.Y., and Anthony J.C. Possible age-associated bias in reporting of clinical features of drug dependence: epidemiological evidence on adolescent-onset marijuana use. Addiction 98 (2003) 71-82
7. 9-tetrahydrocannabinol in man on mood and performance measures: a dose-response study. Pharmacol Biochem Behav 35 (1990) 861-864
8. Cornelius J.R., Chung T., Martin C., Wood D.S., and Clark D.B. Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependence. Addict Behav (2008) 10.1016/j.addbeh.2008.02.001
9. 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology 264 (2002) 61-70
10. Haney M., Hart C.L., Vosburg S.K., Nasser J., Bennett A., Zubaran C., et al. Marijuana withdrawal in humans: effects of oral THC or divalproex. Neuropsychopharmacology 29 (2004) 158-170
11. Hart C.L. Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. Drug Alcohol Depend 80 (2005) 147-159
12. Hart C.L., Haney M., Foltin R.W., and Fischman M.W. Effects of the NMDA antagonist memantine on human methamphetamine discrimination. Psychopharmacology 164 (2002) 376-384
13. 9-THC in male marijuana smokers in a laboratory choice procedure. Psychopharmacology 181 (2005) 237-243
14. Hart C.L., van Gorp W., Haney M., Foltin R.W., and Fischman M.W. Effects of acute smoked marijuana on complex cognitive performance. Neuropsychopharmacology 25 (2001) 757-765
15. 9-tetrahydrocannabinol in humans. Psychopharmacology 164 (2002) 407-415
16. Heishman S.J., Arasteh K., and Stitzer M.L. Comparative effects of alcohol and marijuana on mood, memory, and performance. Pharmacol Biochem Behav 58 (1997) 93-101
17. Heishman S.J., Stitzer M.L., and Bigelow G.E. Alcohol and marijuana: comparative dose effect profiles in humans. Pharmacol Biochem Behav 31 (1988) 649-655
18. Heishman S.J., Stitzer M.L., and Yingling J.E. Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjective reports, and performance. Pharmacol Biochem Behav 34 (1989) 173-179
19. International Narcotics Control Board. Annual Report. Vienna: United Nations Information Service (2007). http://www.incb.org/pdf/annual-report/2007/en/press-kit.pdf Available from: URL: http://www.incb.org/pdf/annual-report/2007/en/press-kit.pdf [accessed on April 3, 2008]
20. Johnston L.D., O'Malley P.M., Bachman J.G., and Schulenberg J.E. Overall, illicit drug use by American teens continues gradual decline in 2007 (2007), University of Michigan News and Information Services, Ann Arbor, MI. http://www.monitoringthefuture.org Available from: URL: http://www.monitoringthefuture.org [accessed on January 8, 2008]
21. Kalachnik, J.E. Standardized Monitoring for Psychopharmacologic Medication Side Effects. Manual for the Monitoring of Side Effects Scale (MOSES). Columbia, SC: University of South Carolina, School of Medicine, Department of Pediatrics, Center for Disability Resources, Columbia, SC, and the South Carolina Department of Disabilities and Special Needs; 2001.
22. McLeod D.R., Griffiths R.R., Bigelow G.E., and Yingling J. An automated version of the digit symbol substitution test (DSST). Behav Res Meth Instr 14 (1982) 463-466
23. Pickworth W.B., Rohrer M.S., and Fant R.V. Effects of abused drugs on psychomotor performance. Exp Clin Psychopharmacol 5 (1997) 235-241
24. Ponto L.L., O'Leary D.S., Koeppel J., Block R.I., Watkins G.L., Richmond J.C., et al. Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users. J Clin Pharmacol 44 (2004) 751-766
25. Roberts R., Rodriguez W., Murphy D., and Crescenzi T. Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. JAMA 290 (2003) 905-911
26. Substance Abuse and Mental Health Services Administration. Results from the 2006 National Survey on Drug Use and Health: National Findings (Office of Applied Studies, NSDUH Series H-32, DHHS Publication No. SMA 07-4293). Rockville, MD: United States Department of Health and Human Services; 2007.
27. Wilson W.H., Ellinwood E.H., Mathew R.J., and Johnson K. Effects of marijuana on performance of a computerized cognitive-neuromotor test battery. Psychiatry Res 51 (1994) 115-125