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The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
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Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., and Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 7 (1998) 1369-1376
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An investigation of polymorphism in the interleukin-10 gene promoter
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Turner D.M., Williams D.M., Sankaran D., Lazarus M., Sinnott P.J., and Hutchinson I.V. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24 1 (1997) 1-8
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Turner, D.M.1
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6
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0033854873
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Lack of association between human TGF-beta1 gene variants and primary hypertension
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Frossard P.M., Pravica V., Perrey C., Hutchinson I.V., and Lukic M.L. Lack of association between human TGF-beta1 gene variants and primary hypertension. Am J Hypertens 13 8 (2000) 944-945
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7
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Awad M.R., Webber S., Boyle G., Sturchioc C., Ahmed M., Martell J., Law Y., Miller S.A., Bowman P., Gribar S., et al. The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. J Heart Lung Transplant 20 6 (2001) 625-630
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Law, Y.7
Miller, S.A.8
Bowman, P.9
Gribar, S.10
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8
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-
0030930830
-
Cytokine gene polymorphism and heart transplant rejection
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For the first time, this study outlines the importance of studying SNPs in combination, rather than in isolation.
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Turner D., Grant S.C., Yonan N., Sheldon S., Dyer P.A., Sinnott P.J., and Hutchinson I.V. Cytokine gene polymorphism and heart transplant rejection. Transplantation 64 5 (1997) 776-779. For the first time, this study outlines the importance of studying SNPs in combination, rather than in isolation.
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Turner, D.1
Grant, S.C.2
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Sinnott, P.J.6
Hutchinson, I.V.7
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9
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Ternstrom L., Jeppsson A., Ricksten A., and Nilsson F. Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy. J Heart Lung Transplant 24 4 (2005) 433-438
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J Heart Lung Transplant
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Ternstrom, L.1
Jeppsson, A.2
Ricksten, A.3
Nilsson, F.4
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10
-
-
0035664542
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Influence of tumor necrosis factor-alpha gene-308 polymorphism on the development of coronary vasculopathy after cardiac transplantation
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Densem C.G., Hutchinson I.V., Yonan N., and Brooks N.H. Influence of tumor necrosis factor-alpha gene-308 polymorphism on the development of coronary vasculopathy after cardiac transplantation. J Heart Lung Transplant 20 12 (2001) 1265-1273
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J Heart Lung Transplant
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Densem, C.G.1
Hutchinson, I.V.2
Yonan, N.3
Brooks, N.H.4
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11
-
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18844401943
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Interleukin-6 polymorphism: a genetic risk factor for cardiac transplant related coronary vasculopathy?
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Densem C.G., Ray M., Hutchinson I.V., Yonan N., and Brooks N.H. Interleukin-6 polymorphism: a genetic risk factor for cardiac transplant related coronary vasculopathy?. J Heart Lung Transplant 24 5 (2005) 559-565
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J Heart Lung Transplant
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Densem, C.G.1
Ray, M.2
Hutchinson, I.V.3
Yonan, N.4
Brooks, N.H.5
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12
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47049104607
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Genetic polymorphisms impact the risk of acute rejection in pediatric heart transplantation: a multi-institutional study
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Genetic polymorphism combinations as independent predictors for rejection profile in pediatric heart recipients.
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Girnita D.M., Brooks M.M., Webber S.A., Burckart G.J., Ferrell R., Zdanowicz G., DeCroo S., Smith L., Chinnock R., Canter C., et al. Genetic polymorphisms impact the risk of acute rejection in pediatric heart transplantation: a multi-institutional study. Transplantation 85 11 (2008) 1632-1639. Genetic polymorphism combinations as independent predictors for rejection profile in pediatric heart recipients.
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Girnita, D.M.1
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Ferrell, R.5
Zdanowicz, G.6
DeCroo, S.7
Smith, L.8
Chinnock, R.9
Canter, C.10
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13
-
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33845917818
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Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients
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Racial distribution of 16 SNPs of cytokine, growth factors, cytotoxic molecules, and pharmacogenomic factors in pediatric heart transplanted patients.
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Girnita D.M., Webber S.A., Ferrell R., Burckart G.J., Brooks M.M., McDade K.K., Chinnock R., Canter C., Addonizio L., Bernstein D., et al. Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients. Transplantation 82 12 (2006) 1774-1780. Racial distribution of 16 SNPs of cytokine, growth factors, cytotoxic molecules, and pharmacogenomic factors in pediatric heart transplanted patients.
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Girnita, D.M.1
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McDade, K.K.6
Chinnock, R.7
Canter, C.8
Addonizio, L.9
Bernstein, D.10
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14
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0033400238
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Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene
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Brogan I.J., Khan N., Isaac K., Hutchinson J.A., Pravica V., and Hutchinson I.V. Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene. Hum Immunol 60 12 (1999) 1245-1249
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Brogan, I.J.1
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15
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0037442985
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Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
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Stevens A., Soden J., Brenchley P.E., Ralph S., and Ray D.W. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 63 4 (2003) 812-816
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Stevens, A.1
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16
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33646798768
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Genetic polymorphism in platelet-derived growth factor and vascular endothelial growth factor are significantly associated with cardiac allograft vasculopathy
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Tambur A.R., Pamboukian S., Costanzo M.R., and Heroux A. Genetic polymorphism in platelet-derived growth factor and vascular endothelial growth factor are significantly associated with cardiac allograft vasculopathy. J Heart Lung Transplant 25 6 (2006) 690-698
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Tambur, A.R.1
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17
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1642399709
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The effect of recipient cytokine gene polymorphism on cardiac transplantation outcome
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Gourley I.S., Denofrio D., Rand W., Desai S., Loh E., and Kamoun M. The effect of recipient cytokine gene polymorphism on cardiac transplantation outcome. Hum Immunol 65 3 (2004) 248-254
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Gourley, I.S.1
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Kamoun, M.6
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18
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33645637027
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Impact of TGFbeta1 gene polymorphisms on acute and chronic rejection in pediatric heart transplant allografts
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Di Filippo S., Zeevi A., McDade K.K., Bastien O., and Webber S.A. Impact of TGFbeta1 gene polymorphisms on acute and chronic rejection in pediatric heart transplant allografts. Transplantation 81 6 (2006) 934-939
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Di Filippo, S.1
Zeevi, A.2
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Bastien, O.4
Webber, S.A.5
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19
-
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4744358701
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Donor and recipient-transforming growth factor-beta 1 polymorphism and cardiac transplant-related coronary artery disease
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Densem C.G., Hutchinson I.V., Yonan N., and Brooks N.H. Donor and recipient-transforming growth factor-beta 1 polymorphism and cardiac transplant-related coronary artery disease. Transplant Immunol 13 3 (2004) 211-217
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Transplant Immunol
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Densem, C.G.1
Hutchinson, I.V.2
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20
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34248675212
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The challenge of renal function in heart transplant children
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Di Filippo S., Cochat P., and Bozio A. The challenge of renal function in heart transplant children. Pediatr Nephrol (Berlin, Germany) 22 3 (2007) 333-342
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Di Filippo, S.1
Cochat, P.2
Bozio, A.3
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21
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33845951304
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The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation
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Large and comprehensive study on the impact of TGF-β1 SNPs and calciuneurin inhibitor-induced end-stage renal failure, following heart transplantation.
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van de Wetering J., Weimar C.H., Balk A.H., Roodnat J.I., Holweg C.T., Baan C.C., van Domburg R.T., and Weimar W. The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation. Transplantation 82 12 (2006) 1744-1748. Large and comprehensive study on the impact of TGF-β1 SNPs and calciuneurin inhibitor-induced end-stage renal failure, following heart transplantation.
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(2006)
Transplantation
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, pp. 1744-1748
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-
van de Wetering, J.1
Weimar, C.H.2
Balk, A.H.3
Roodnat, J.I.4
Holweg, C.T.5
Baan, C.C.6
van Domburg, R.T.7
Weimar, W.8
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22
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13444259636
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Impact of TGFbeta1 gene polymorphisms on late renal function in pediatric heart transplantation
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Di Filippo S., Zeevi A., McDade K.K., Boyle G.J., Miller S.A., Gandhi S.K., and Webber S.A. Impact of TGFbeta1 gene polymorphisms on late renal function in pediatric heart transplantation. Hum Immunol 66 2 (2005) 133-139
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(2005)
Hum Immunol
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, pp. 133-139
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Di Filippo, S.1
Zeevi, A.2
McDade, K.K.3
Boyle, G.J.4
Miller, S.A.5
Gandhi, S.K.6
Webber, S.A.7
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23
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2342527023
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Interleukin-10 production genotype protects against acute persistent rejection after lung transplantation
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Zheng H.X., Burckart G.J., McCurry K., Webber S., Ristich J., Iacono A., Dauber J., McDade K., Grgurich W., Zaldonis D., et al. Interleukin-10 production genotype protects against acute persistent rejection after lung transplantation. J Heart Lung Transplant 23 5 (2004) 541-546
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(2004)
J Heart Lung Transplant
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, pp. 541-546
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Zheng, H.X.1
Burckart, G.J.2
McCurry, K.3
Webber, S.4
Ristich, J.5
Iacono, A.6
Dauber, J.7
McDade, K.8
Grgurich, W.9
Zaldonis, D.10
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24
-
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0037112739
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Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation
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Lu K.C., Jaramillo A., Lecha R.L., Schuessler R.B., Aloush A., Trulock E.P., Mendeloff E.N., Huddleston C.B., Alexander Patterson G., and Mohanakumar T. Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. Transplantation 74 9 (2002) 1297-1302
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(2002)
Transplantation
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, pp. 1297-1302
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Lu, K.C.1
Jaramillo, A.2
Lecha, R.L.3
Schuessler, R.B.4
Aloush, A.5
Trulock, E.P.6
Mendeloff, E.N.7
Huddleston, C.B.8
Alexander Patterson, G.9
Mohanakumar, T.10
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25
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33750609290
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Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant
-
Snyder L.D., Hartwig M.G., Ganous T., Davis R.D., Herczyk W.F., Reinsmoen N.L., Schwartz D.A., and Palmer S.M. Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant. J Heart Lung Transplant 25 11 (2006) 1330-1335
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(2006)
J Heart Lung Transplant
, vol.25
, Issue.11
, pp. 1330-1335
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-
Snyder, L.D.1
Hartwig, M.G.2
Ganous, T.3
Davis, R.D.4
Herczyk, W.F.5
Reinsmoen, N.L.6
Schwartz, D.A.7
Palmer, S.M.8
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26
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33847742648
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Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14
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Innate immune receptor gene polymorphisms can also contribute to the onset and severity of rejection in lung recipients.
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Palmer S.M., Klimecki W., Yu L., Reinsmoen N.L., Snyder L.D., Ganous T.M., Burch L., and Schwartz D.A. Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. Am J Transplant 7 3 (2007) 693-699. Innate immune receptor gene polymorphisms can also contribute to the onset and severity of rejection in lung recipients.
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(2007)
Am J Transplant
, vol.7
, Issue.3
, pp. 693-699
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-
Palmer, S.M.1
Klimecki, W.2
Yu, L.3
Reinsmoen, N.L.4
Snyder, L.D.5
Ganous, T.M.6
Burch, L.7
Schwartz, D.A.8
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27
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17444425361
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The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology
-
This study outlines the impact of pro-inflammatory cytokine SNPs on various forms of rejection in renal transplantation.
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Tinckam K., Rush D., Hutchinson I., Dembinski I., Pravica V., Jeffery J., and Nickerson P. The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology. Transplantation 79 7 (2005) 836-841. This study outlines the impact of pro-inflammatory cytokine SNPs on various forms of rejection in renal transplantation.
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(2005)
Transplantation
, vol.79
, Issue.7
, pp. 836-841
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-
Tinckam, K.1
Rush, D.2
Hutchinson, I.3
Dembinski, I.4
Pravica, V.5
Jeffery, J.6
Nickerson, P.7
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28
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41349114022
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Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation
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Manchanda P.K., and Mittal R.D. Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation. Mol Cell Biochem 311 1-2 (2008) 57-65
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(2008)
Mol Cell Biochem
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, pp. 57-65
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Manchanda, P.K.1
Mittal, R.D.2
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29
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37349016203
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Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation
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Brabcova I., Petrasek J., Hribova P., Hyklova K., Bartosova K., Lacha J., and Viklicky O. Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation. Transplantation 84 8 (2007) 1037-1044
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(2007)
Transplantation
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, pp. 1037-1044
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Brabcova, I.1
Petrasek, J.2
Hribova, P.3
Hyklova, K.4
Bartosova, K.5
Lacha, J.6
Viklicky, O.7
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30
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33847749299
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Cytokine gene polymorphisms in renal transplant recipients
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Azarpira N., Aghdaie M.H., Geramizadeh B., Behzadi S., Nikeghbalian S., Sagheb F., Rahsaz M., Behzad-Behbahanie A., Ayatollahi M., Darai M., et al. Cytokine gene polymorphisms in renal transplant recipients. Exp Clin Transplant 4 2 (2006) 528-531
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(2006)
Exp Clin Transplant
, vol.4
, Issue.2
, pp. 528-531
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Azarpira, N.1
Aghdaie, M.H.2
Geramizadeh, B.3
Behzadi, S.4
Nikeghbalian, S.5
Sagheb, F.6
Rahsaz, M.7
Behzad-Behbahanie, A.8
Ayatollahi, M.9
Darai, M.10
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31
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34548609382
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Influence of cytokine genes polymorphisms on long-term outcome in renal transplantation
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Breulmann B., Bantis C., Siekierka M., Blume C., Aker S., Kuhr N., Grabensee B., and Ivens K. Influence of cytokine genes polymorphisms on long-term outcome in renal transplantation. Clin Transplant 21 5 (2007) 615-621
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(2007)
Clin Transplant
, vol.21
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, pp. 615-621
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-
Breulmann, B.1
Bantis, C.2
Siekierka, M.3
Blume, C.4
Aker, S.5
Kuhr, N.6
Grabensee, B.7
Ivens, K.8
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32
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30144434975
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Immune response gene polymorphisms in renal transplant recipients
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Dmitrienko S., Hoar D.I., Balshaw R., and Keown P.A. Immune response gene polymorphisms in renal transplant recipients. Transplantation 80 12 (2005) 1773-1782
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(2005)
Transplantation
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, pp. 1773-1782
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Dmitrienko, S.1
Hoar, D.I.2
Balshaw, R.3
Keown, P.A.4
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33
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37349075804
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Cytokine gene polymorphism in kidney transplantation-impact of TGF-beta 1, TNF-alpha and IL-6 on graft outcome
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Nikolova P.N., Ivanova M.I., Mihailova S.M., Myhailova A.P., Baltadjieva D.N., Simeonov P.L., Paskalev E.K., and Naumova E.J. Cytokine gene polymorphism in kidney transplantation-impact of TGF-beta 1, TNF-alpha and IL-6 on graft outcome. Transplant Immunol 18 4 (2008) 344-348
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(2008)
Transplant Immunol
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, pp. 344-348
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Nikolova, P.N.1
Ivanova, M.I.2
Mihailova, S.M.3
Myhailova, A.P.4
Baltadjieva, D.N.5
Simeonov, P.L.6
Paskalev, E.K.7
Naumova, E.J.8
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34
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33646839000
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Interleukin-1beta and receptor antagonist (IL-1Ra) gene polymorphisms and the prediction of the risk of end-stage renal disease
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Manchanda P.K., Kumar A., Bid H.K., and Mittal R.D. Interleukin-1beta and receptor antagonist (IL-1Ra) gene polymorphisms and the prediction of the risk of end-stage renal disease. Biomarkers 11 2 (2006) 164-173
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Biomarkers
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, pp. 164-173
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Manchanda, P.K.1
Kumar, A.2
Bid, H.K.3
Mittal, R.D.4
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35
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33744923957
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Relationship between subclinical rejection and genotype, renal messenger RNA, and plasma protein transforming growth factor-beta1 levels
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Hueso M., Navarro E., Moreso F., Beltran-Sastre V., Ventura F., Grinyo J.M., and Seron D. Relationship between subclinical rejection and genotype, renal messenger RNA, and plasma protein transforming growth factor-beta1 levels. Transplantation 81 10 (2006) 1463-1466
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(2006)
Transplantation
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, pp. 1463-1466
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Hueso, M.1
Navarro, E.2
Moreso, F.3
Beltran-Sastre, V.4
Ventura, F.5
Grinyo, J.M.6
Seron, D.7
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36
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50549088987
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Association between cytokine gene polymorphisms and outcomes in renal transplantation: a meta-analysis of individual patient data
-
Large meta-analysis that reports the independent effect of HLA-ABDR mismatch, age at the time of transplant, and SNPs on poor outcome in renal recipients.
-
Thakkinstian A., Dmitrienko S., Gerbase-Delima M., McDaniel D.O., Inigo P., Chow K.M., McEvoy M., Ingsathit A., Trevillian P., Barber W.H., et al. Association between cytokine gene polymorphisms and outcomes in renal transplantation: a meta-analysis of individual patient data. Nephrol Dial Transplant (2008). Large meta-analysis that reports the independent effect of HLA-ABDR mismatch, age at the time of transplant, and SNPs on poor outcome in renal recipients.
-
(2008)
Nephrol Dial Transplant
-
-
Thakkinstian, A.1
Dmitrienko, S.2
Gerbase-Delima, M.3
McDaniel, D.O.4
Inigo, P.5
Chow, K.M.6
McEvoy, M.7
Ingsathit, A.8
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