Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze

Behavioural Brain Research

Volumn 194, Issue 2, 2008, Pages 181-186

  Moraes, Cladis L K ^a   Bertoglio, Leandro J ^a   Carobrez, Antonio P ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Anxiety; Elevated plus maze; Glutamate; Periaqueductal gray; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; MALE; MAZE TEST; NEUROTRANSMISSION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR UPREGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; MALE; MAZE LEARNING; N-METHYLASPARTATE; PERIAQUEDUCTAL GRAY; PIPERAZINES; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 50549089325     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.07.005     Document Type: Article

References (33)

1. Beart P.M., Nicolopoulos L.S., West D.C., and Headley P.M. An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence. Neurosci Lett 85 (1988) 205-211
2. Beckett S.R., Lawrence A.J., Marsden C.A., and Marshall P.W. Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray. Psychopharmacology 108 (1992) 110-114
3. Beckett S., and Marsden C.A. The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour. J Psychopharmacol 11 (1997) 35-40
4. Beitz A.J., and Williams F.G. Localization of putative amino acid transmitters in the PAG and their relationship to the PAG-Raphe magnus pathway. In: Depaulis A., and Bandler R. (Eds). The midbrain periaqueductal gray matter (1991), Plenum Press, New York
5. Bergink V., van Megen H.J., and Westenberg H.G. Glutamate and anxiety. Eur Neuropsychopharmacol 14 (2004) 175-183
6. Bertoglio L.J., and Zangrossi. Involvement of dorsolateral periaqueductal gray N-methyl-d-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze. Behav Pharmacol 17 (2006) 589-596
7. Bittencourt A.S., Carobrez A.P., Zamprogno L.P., Tufik S., and Schenberg L.C. Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of N-methyl-d-aspartic acid glutamate receptors. Neuroscience 125 (2004) 71-89
8. Carobrez A.P., Teixeira K.V., and Graeff F.G. Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor. Neurosci Biobehav Rev 25 (2001) 697-709
9. Carobrez A.P., and Bertoglio L.J. Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci Biobehav Rev 29 (2005) 1193-1205
10. Carrive P. The periaqueductal gray and defensive behavior: functional representation and neuronal organization. Behav Brain Res 58 (1993) 27-47
11. Deakin J.F.W., and Graeff F.G. 5-HT and mechanisms of defense. J Psychopharmacol 5 (1991) 305-315
12. De Paula Soares V., and Zangrossi Jr. H. Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res Bull 64 (2004) 181-188
13. De Souza M.M., Schenberg L.C., and de Pádua Carobrez A. NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance. Behav Brain Res 90 (1998) 157-165
14. Fanselow M.S. The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In: Depaulis A., and Bandler R. (Eds). The midbrain periaqueductal gray matter (1991), Plenum, New York
15. Graeff F.G. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz J Med Biol Res 27 (1994) 811-829
16. Graeff F.G. On serotonin and experimental anxiety. Psychopharmacology 163 (2002) 467-476
17. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 65 (1995) 319-395
18. Jenck F., Broekkamp C.L., and Van Delft A.M. Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors. Psychopharmacology 97 (1989) 489-495
19. Kalynchuk L.E., Pinel J.P., Treit D., and Kippin T.E. Changes in emotional behavior produced by long-term amygdala kindling in rats. Biol Psychiatry 41 (1997) 438-451
20. Lovick T.A., Parry D.M., Stezhka V.V., and Lumb B.M. Serotonergic transmission in the periaqueductal gray matter in relation to aversive behaviour: morphological evidence for direct modulatory effects on identified output neurons. Neuroscience 95 (2000) 763-772
21. Lowry C.A., Johnson P.L., Hay-Schmidt A., Mikkelsen J., and Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress 8 (2005) 233-246
22. Lu C.L., Shaikh M.B., and Siegel A. Role of NMDA receptors in hypothalamic facilitation of feline defensive rage elicited from the midbrain periaqueductal gray. Brain Res 581 (1992) 123-132
23. Millan M.J. The neurobiology and control of anxious states. Prog Neurobiol 70 (2003) 83-244
24. Morimoto K. Seizure-triggering mechanisms in the kindling model of epilepsy: collapse of GABA-mediated inhibition and activation of NMDA receptors. Neurosci Biobehav Rev 13 (1989) 253-260
25. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 4th ed. (1998), Academic Press, New York
26. Rodgers R.J., and Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 21 (1997) 801-810
27. Schmitt M.L., Coelho W., Lopes-de-Souza A.S., Guimarães F.S., and Carobrez A.P. Anxiogenic-like effect of glycine and d-serine microinjected into dorsal periaqueductal gray matter of rats. Neurosci Lett 189 (1995) 93-96
28. Setem J., Pinheiro A.P., Motta V.A., Morato S., and Cruz A.P. Ethopharmacological analysis of 5-HT ligands on the rat elevated plus-maze. Pharmacol Biochem Behav 62 (1999) 515-521
29. Shaikh M.B., De Lanerolle N.C., and Siegel A. Serotonin 5-HT1A and 5-HT2/1C receptors in the midbrain periaqueductal gray differentially modulate defensive rage behavior elicited from the medial hypothalamus of the cat. Brain Res 765 (1997) 198-207
30. Silveira M.C., and Graeff F.G. Defense reaction elicited by microinjection of kainic acid in the medial hypothalamus of the rat. Braz J Med Biol Res 21 (1988) 569-571
31. Teixeira K.V., and Carobrez A.P. Effects of glycine or (+/-)-3-amino-1-hydroxy-2-pyrrolidone microinjections along the rostrocaudal axis of the dorsal periaqueductal gray matter on rats' performance in the elevated plus-maze task. Behav Neurosci 113 (1999) 196-203
32. Viana M.B., Graeff F.G., and Löschmann P.A. Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray. Pharmacol Biochem Behav 58 (1997) 167-172
33. Walker D.L., and Davis M. Involvement of the dorsal periaqueductal gray in the loss of fear-potentiated startle accompanying high footshock training. Behav Neurosci 111 (1997) 692-702