Identification and quantification of inhibitors for angiotensin-converting enzyme in hypoallergenic infant milk formulas

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 15, 2008, Pages 6333-6338

  Martin, Melanie ^a   Wellner, Anne ^a   Ossowski, Ines ^a   Henle, Thomas ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Angiotensin converting enzyme; Bioactive peptides; Blood pressure; HPLC MS; Infant nutrition

Indexed keywords

ALLERGEN; DIPEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MILK PROTEIN;

ARTICLE; ARTIFICIAL MILK; BREAST MILK; CHEMISTRY; HUMAN; HYDROLYSIS; IMMUNOLOGY; INFANT; MILK ALLERGY; NEWBORN;

ALLERGENS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; DIPEPTIDES; HUMANS; HYDROLYSIS; INFANT; INFANT FORMULA; INFANT, NEWBORN; MILK HYPERSENSITIVITY; MILK PROTEINS; MILK, HUMAN;

EID: 50449107794     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf800865b     Document Type: Article

References (17)

1. Skeggs, L. T.; Kahn, J. E.; Shumway, N. P. The preparation and function of the angiotensin-converting enzyme. J. Exp. Med. 1956, 103, 295-299.
2. Erdos, E. G. Angiotensin-I converting enzyme. Circ. Res. 1975, 36, 247-255.
3. Ondetti, M. A.; Rubin, B.; Cushman, D. W. Design of specific inhibitors of angiotensin converting enzyme: A new class of orally active antihypertensive agents. Science 1977, 196, 441-444.
4. FitzGerald, R. J.; Meisel, H. Lactokinins: Whey protein-derived ACE inhibitory peptides. Nahrung 1999, 43, 165-167.
5. Hata, Y.; Yamamoto, M.; Ohni, M.; Nakajima, K.; Nakamura, Y.; Takano, T. A placebo-controlled study of the effect of a sour milk on blood pressure in hypertensive subjects. Am. J. Clin. Nutr. 1996, 64, 767-771.
6. Mizushima, S.; Ohshige, K.; Watanabe, J.; Kimura, M.; Kadowaki, T.; Nakamura, Y.; Tochikubo, O.; Ueshima, H. Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am. J. Hypertens. 2004, 17, 701-706.
7. Nakamura, Y.; Masuda, O.; Takano, T. Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci., Biotechnol., Biochem. 1996, 60, 488-489.
8. Meisel, H.; Goepfert; Günther, S. ACE-inhibitory activities in milk products. Milchwissenschaft 1997, 52, 307-311.
9. Lee, Y. M.; Skurk, T.; Hennig, M.; Hauner, H. Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur. J. Nutr. 2007, 46, 21-27.
10. Engberink, M. F.; Schouten, E. G.; Kok, F. J.; van Mierlo, L. A.; Brouwer, I. A.; Gekijnse, J. M. Lactotripeptides show no effect on human blood pressure: Results from a double-blind randomized controlled trial. Hypertension 2008, 51, 399-405.
11. Exl, B.-M. A review of recent developments in the use of moderately hydrolyzed whey formulae in infant nutrition. Nutr. Res. 2001, 21, 355-379.
12. Hernández-Ledesma, B.; Amigo, L.; Ramos, M.; Recio, I. Release of angiotensin converting enzyme-inhibitory peptides by simulated gastrointestinal digestion of infant formulas. Int. Dairy J. 2004, 14, 889-889.
13. Cheung, H.-S.; Wang, F.-L.; Ondetti, M. A.; Sabo, E. F.; Cushman, D. W. Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem. 1980, 255, 401-407.
14. Sato, M.; Hosokawa, T.; Yamaguchi, T.; Nakano, T.; Muramoto, K.; Kahara, T.; Funayama, K.; Kobayashi, A.; Nakano, T. Angiotensin I-converting enzyme inhibitory peptides derived from Wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive tats. J. Agric. Food Chem 2002, 50, 6245-6252.
15. Fox, P. F. Milk proteins: General and historical aspects. In Advanced Dairy Chemistry, Part A, 3rd ed.; Fox, P. F., McSweeney, P. L. H., Eds.; Kluwer Academic/Plenum Publishers: New York, 2003; pp 1-48.
16. Hernandez-Ledesma, B.; Recio, I.; Ramos, M.; Amigo, L. Preparation of ovine and caprine β-lactoglobulin hydroryzates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolyzed with thermolysin. Int. Diary J. 2002, 12, 805-812.
17. Lopez-Fandino, R.; Otte, J.; van Camp, J. Physiological, chemical and technological peptides with antihypertensive and ACE-inhibitory activity. Int. Diary J. 2006, 16, 277-293.