Eccentric dosing of nitrates does not increase cardiac events in patients with healed myocardial infarction

Hypertension Research

Volumn 27, Issue 8, 2004, Pages 563-572

  Kanamasa, Ken ^a   Naito, Norikatsu ^a   Morii, Hideki ^a   Nakano, Kazue ^a   Tanaka, Yasushi ^a   Kitayama, Koji ^a   Haku, Ryo ^a   Kai, Tatsuya ^a   Yonekawa, Osamu ^a   Nagatani, Yusuke ^a   Ishikawa, Kinji ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac events; Myocardial infarction; Nitrates; Secondary prevention

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; ISOSORBIDE MONONITRATE; NITRIC ACID DERIVATIVE; WARFARIN;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY THROMBOSIS; DISEASE ASSOCIATION; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE REGIMEN; FEMALE; HEART ATRIUM FIBRILLATION; HEART DEATH; HEART INFARCTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOMES RESEARCH; REBOUND; RECURRENT DISEASE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SUDDEN DEATH; SURVIVAL RATE; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

AGED; ANGINA PECTORIS; FEMALE; HEART FAILURE, CONGESTIVE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIUM; NITROGLYCERIN; RECURRENCE; RISK FACTORS; SURVIVAL RATE; VASODILATOR AGENTS; WOUND HEALING;

EID: 5044249249     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.27.563     Document Type: Article

References (58)

1. Jugdutt BI: Role of nitrates after acute myocardial infarction. Am J Cardiol 1992; 70: 82B-87B.
2. Fitzgerald LJ, Bennett ED: The effects of oral isosorbide 5-mononitrate on mortality following acute myocardial infarction: a multicentre study. Eur Heart J 1990; 11: 120-126.
3. Yusuf S, Sleight P, Held P, et al: Routine medical management of acute myocardial infarction: lessons from overviews of recent randomized controlled trials. Circulation 1990; 82 (Suppl II): II-117-II-134.
4. Committee on Management of Acute Myocardial Infarction: 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: executive summary and recommendations: a report of the American College of Cardiology/American Heart Association Task Force of Practice Guidelines. Circulation 1999; 100: 1016-1030.
5. FDA: Oral anti-anginal nitrates should be indicated only for single, not chronic, use in absence of long-term data, FDA Cardio-Renal Drugs Advisory CMTE, concludes. FDA Reports "The Pink Sheet." 1993, p16.
6. Gruppo Italiano per lo Studio della Sopravvivenza nell' Infarto Miocardico: GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994; 343: 1115-1122.
7. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group: ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected acute myocardial infarction. Lancet 1995; 345: 669-685.
8. Ishikawa K, Kanamasa K, Ogawa I, et al: Long-term nitrate treatment increases cardiac events in patients with healed myocardial infarction. Jpn Circ J 1996; 60: 779-788.
9. Nakamura Y, Moss AJ, Brown MW, et al: Chronic nitrate use may be deleterious in ischemic heart disease: a study using the databases from two large-scale post-infarction studies. Am Heart J 1999; 138: 577-585.
10. Crean PA, Ribeiro P, Crea F, et al: Failure of transdermal nitroglycerin to improve chronic stable angina: a randomized, placebo-controlled, double-blind, double crossover trial. Am Heart J 1984; 108: 1494-1500.
11. Sullivan M, Savvides M, Abouantoun S, et al: Failure of transdermal nitroglycerin to improve exercise capacity in patients with angina pectoris. J Am Coll Cardiol 1985; 5: 1220-1223.
12. Parker JO, Fung HI: Transdermal nitroglycerin in angina pectoris. Am J Cardiol 1984; 54: 471-476.
13. Steering Committee: Transdermal Nitroglycerin Cooperative Study: acute and chronic anti-anginal efficacy of continuous twenty-four hour application of transdermal nitroglycerin. Am J Cardiol 1991; 68: 1263-1273.
14. DeMots H, Glasser SP, on behalf of the Transderm-Nitro Trial Study Group: Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina. J Am Coll Cardiol 1989; 13: 786-793.
15. Cowan JC, Bourke JP, Reid DS: Prevention of tolerance to nitroglycerin patches by overnight removal. Am J Cardiol 1987; 60: 271-275.
16. Parker JD, Farrell B, Fenton T, et al: Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin. Circulation 1991; 84: 2336-2345.
17. Ferratini M, Pirelli S, Merlini P, et al: Intermittent transdermal nitroglycerin monotherapy in stable exercise-induced angina: a comparison with a continuous schedule. Eur Heart J 1989; 10: 998-1002.
18. Forrester JS, Diamond GA, Swan HJC: Correlative classification of clinical and hemodynamic function after acute myocardial infarction. Am J Cardiol 1977; 39: 137-145.
19. Killip T III, Kimball JT: Treatment of myocardial infarction in a coronary care unit: a two years experience with 250 patients. Am J Cardiol 1967; 20: 457-464.
20. Heger JJ, Weyman AE, Wann LS, et al: Cross-sectional echocardiographic analysis of the extent of left ventricular asynergy in acute myocardial infarction. Circulation 1980; 61: 1113-1118.
21. Wagner GS, Freye CJ, Palmeri ST, et al: Evaluation of a QRS scoring system for estimating myocardial infarct size: I: specificity and observer agreement. Circulation 1982; 65: 342-347.
22. Prinzmetal M, Kennamer R, Merliss R, et al: Angina pectoris: I: a variant form of angina pectoris: preliminary report. Am J Med 1959; 27: 375-388.
23. Myerburg RJ, Castellanos A: Cardiac arrest and sudden cardiac death, in Braunwald E (ed): Heart Disease, A Textbook of Cardiovascular Medicine, Vol. 1, 4th ed. Philadelphia, WB Saunders Co, 1992, pp 756-789.
24. Schwartz GC, Oliver MF, Ezekowitz MD, et al: Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesteol Lowering (MIRACLE) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction. Am J Cardiol 1998; 81: 578-581.
25. Frishman WH: Tolerance, rebound, and time-zero effect of nitrate therapy. Am J Cardiol 1992; 70: 43G-48G.
26. Rapaport E: Influence of long-acting nitrate therapy on the risk of reinfarction, sudden death, and total mortality in survivors of acute myocardial infarction. Am Heart J 1985; 110: 276-280.
27. Rossetti E, Luca C, Bonetti F, et al: Transdermal nitroglycerin reduces the frequency of anginal attacks but fails to prevent silent ischemia. J Am Coll Cardiol 1993; 21: 337-342.
28. Mangione NJ, Glasser SP: Phenomenon of nitrate tolerance. Am Heart J 1994; 128: 137-146.
29. Kai H, Yamamoto H, Noma M, et al: Effects of continuous intravenous infusion of isosorbide dinitrate on development of tolerance to vasodilating action in human epicardial coronary arteries. Am Heart J 1994; 128: 230-236.
30. Gori T, Parker JD: The puzzle of nitrate tolerance: pieces smaller than we thought? Circulation 2002; 106: 2404-2408.
31. Gori T, Parker JD: Nitrate tolerance: a unifying hypothesis. Circulation 2002; 106: 2510-2513.
32. Dupuis J, Lalonde G, Lemieux R, et al: Tolerance to intravenous nitroglycerin in patients with congestive heart failure: role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. J Am Coll Cardiol 1990; 16: 923-931.
33. Elkayam U, Kulick D, McIntosh N, et al: Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure. Circulation 1987; 76: 577-584.
34. Reeves WC, Cook L, Wood MA, et al: Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits. Am J Cardiol 1985; 55: 1066-1069.
35. Molina CR, Andresen JW, Rapoport RM, et al: Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. J Cardiovasc Pharmacol 1987; 10: 371-378.
36. Rydell EL, Axelssom KL: Adrenaline toxicity in mice: sensitization of α1 adrenoreceptors by nitroglycerin. Acta Pharmacol Toxicol 1984; 55: 73-77.
37. Münzel T, Giaid A, Kurz S, et al: Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc Natl Acad Sci USA 1995; 92: 5244-5248.
38. Feldman RL, Pepine CJ, Conti CR: Unusual vasomotor coronary arterial responses after nitroglycerin. Am J Cardiol 1978: 42; 517-519.
39. Bove AA, Vlietstra RE: Paradoxical angina after nitroglycerin - another variant. N Engl J Med 1982: 306; 484-485.
40. Caramori PR, Adelman AG, Azeuedo ER, et al: Therapy with nitroglycerin increases coronary vasoconstriction in response to accetylcholine. J Am Coll Cardiol 1998; 32: 1969-1974.
41. On Y-K, Kim C-H, Oh B-H, Lee M-M, Park Y-B: Effects of angiotensin converting enzyme inhibitor and calcium antagonists on endothelial function in patients with essential hypertension. Hypertens Res 2002; 25: 365-371.
42. Dong J, Fujii S, Goto D, et al: Increase expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. Hypertens Res 2003; 26: 723-729.
43. Yamagishi K, Iso H, Kitamura A, et al: Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res 2003; 26: 209-217.
44. Hasebe N, Kido S, Ido A, Kikuchi K, for the Angiographical Study in Angina with Hypertension Induced insults (ASAHI) Investigators: Reverse J-curve relation between diastolic blood pressure and severity of coronary artery lesion in hypertensive patients with angina pectoris. Hypertens Res 2002; 25: 381-387.
45. Ono A, Fujita T: Factors relating to inadequate control of blood pressure in hypertensive patients. Hypertens Res 2003; 26: 219-224.
46. van den Berg EK, Schmitz JM, Benedict CR, et al: Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology. Circulation 1989; 79: 116-124.
47. Robertson RM, Robertson D, Friesinger GC, et al: Platelet aggregates in peripheral and coronary-sinus blood in patients with spontaneous coronary-artery spasm. Lancet 1980; 2: 829-831.
48. Murakami Y, Ishinaga Y, Sano K, et al: Increased serotonin release across the coronary bed during a nonischemic interval in patients with vasospastic angina. Clin Cardiol 1996; 19: 473-476.
49. Parker JO, Armes MH, Hawkinson RW, et al: Intermittent transdermal nitroglycerin therapy in angina pectoris: clinically effective without tolerance or rebound. Circulation 1995; 91: 1368-1374.
50. Scardi S, Camerini F, Pandullo C, et al: Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort angina: a multicentric study. Int J Cardiol 1991; 32: 241-248.
51. Luke R, Sharpe N, Coxon R: Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application. J Am Coll Cardiol 1987; 10: 642-646.
52. Fox KM, Dargie HJ, Deanfield J, et al: Avoidance of tolerance and lack of rebound with intermittent dose titrated transdermal glyceryl trinitrate. Br Heart J 1991; 66: 151-155.
53. Waters DD, Juneau M, Gossard D, et al: Limited usefulness of intermittent nitroglycerine patches in stable angina. J Am Coll Cardiol 1989; 13: 421-425.
54. Ishikawa K, Yamamoto T, Kanamasa K, et al: Intermittent nitrate therapy for prior myocardial infarction does not induce rebound angina nor reduce cardiac events. Int Med 2000; 39: 1020-1026.
55. Parker JO: Eccentric dosing with isosobide-5-mononitrate in angina pectoris. Am J Cardiol 1993; 72: 871-876.
56. Chrysant SG, Glasser SP, Bittar N, et al: Efficacy and safety of extended-release isosorbide mononitrate for stable effort angina pectoris. Am J Cardiol 1993; 72: 1249-1256.
57. Münzel T, Bassenge E: Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial coronary arteries and prevents rebound coronary vasoconstriction in vivo. Circulation 1996; 93: 2052-2058.
58. Thadani U, Maranda CR, Amsterdam E, et al: Lack of pharmacologic tolerance and rebound angina pectoris during twice-daily therapy with isosorbide-5-mononitrate. Ann Intern Med 1994; 120: 353-359.