Does general anesthesia potentiate the GABA-ergic action of intrathecal baclofen? [4]

Journal of Neurosurgical Anesthesiology

Volumn 16, Issue 4, 2004, Pages 323-324

  Gerçek, Arzu ^a   Baykan, Nigar ^a   Daǧçinar, Adnan ^a   Özek, M Memet ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANESTHETIC AGENT; ATROPINE; BACLOFEN; DIPYRIDAMOLE; LIDOCAINE; PROPOFOL; REMIFENTANIL; SEVOFLURANE; TROPONIN T; VECURONIUM;

ANGIOGRAPHY; ARTIFICIAL VENTILATION; BLOOD CELL COUNT; BOLUS INJECTION; BRAIN HYPOXIA; CATHETER; CEREBRAL PALSY; CREATINE KINASE BLOOD LEVEL; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROLYTE BLOOD LEVEL; END TIDAL CARBON DIOXIDE TENSION; ENDOTRACHEAL INTUBATION; EXERCISE TEST; FOREIGN BODY; GENERAL ANESTHESIA; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART VENTRICLE EXTRASYSTOLE; HUMAN; HYPOTENSION; INFUSION PUMP; INHALATION; LETTER; NEUROLOGIC DISEASE; PEROPERATIVE COMPLICATION; PHYSICAL EXAMINATION; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; QUALITY OF LIFE; SINUS BRADYCARDIA; SKIN DEFECT; SODIUM BLOOD LEVEL; SPASTICITY; SPINAL CORD INJURY; ST SEGMENT ELEVATION; T WAVE; TIDAL VOLUME;

ADOLESCENT; ANESTHESIA, GENERAL; BACLOFEN; DRUG SYNERGISM; ELECTROCARDIOGRAPHY; GABA AGONISTS; HUMANS; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; MUSCLE SPASTICITY; OVERDOSE;

EID: 5044229586     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008506-200410000-00019     Document Type: Letter

References (8)

1. Ordia JI, Fisher E, Adamski E, et al. Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity. J Neurosurg 1996;85:452-457.
2. Lyew MA, Mondy C, Eagle S, et al. Hemodynamic instability and delayed emergence from general anesthesia associated with inadvertent intrathecal baclofen overdose. Anesthesiology. 2003;98:265-268.
3. Perry HE, Wright RO, Shannon MW, et al. Baclofen overdose: drug experimentation in a group of adolescents. Pediatrics. 1998;101:1045-1048.
4. Peng CT, Ger J, Yang CC, et al. Prolonged severe withdrawal symptoms after acute-on-chronic baclofen overdose. J Clin Toxicol. 1998;36:359-363.
5. Kleinman BS, Olshansky B, Collins VJ. Perioperative arrhythmias. In: Collins VJ, ed. Physiologic and Pharmacologic Bases of Anesthesia. Philadelphia, Williams & Wilkins, 1996:113-140.
6. Murugaiah KD, Hemmings HC Jr. Effects of intravenous general anesthetics on 3H-GABA release from rat cortical synaptosomes. Anesthesiology. 1998;89:919-928.
7. Chen CL, Yang YR, Chiu TH. Activation of rat locus coeuleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone. Eur J Pharmacol. 1999;386:201-210.
8. Sallerin-Caute B, Lazorthes Y, Monsarrat B, et al. CSF baclofen levels after intrathecal administration in severe spasticity. Eur J Clin Pharmacol. 1991;40:363-365.