Ectopic hamartomatous thymoma: A clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor

American Journal of Surgical Pathology

Volumn 28, Issue 10, 2004, Pages 1360-1370

  Fetsch, John F ^a   Laskin, William B ^b   Michal, Michal ^c   Remotti, Fabrizio ^d   Heffner, Dennis ^a   Ellis, Gary ^a,f   Furlong, Mary ^e   Miettinen, Markku ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

^d Coll Phys/Surgs of Columbia Univ ^*  (United States)

^e GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f ARUP LABORATORIES   (United States)

Author keywords

Branchial cleft; Cervical sinus of His; Embryology; Immunohistochemistry; Keratin; Lateral cervical cyst; Mixed tumor; Neck; Salivary gland tumor; Soft tissue tumor; Sternoclavicular joint; Synovial sarcoma

Indexed keywords

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BRANCHIAL ANLAGE MIXED TUMOR; BRANCHIAL ARCH; CELL COUNT; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; ECTOPIC HAMARTOMATOUS THYMOMA; EXCISION; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MITOSIS; MIXED TUMOR; MYOEPITHELIUM CELL; NECK TUMOR; NERVE SHEATH TUMOR; PREOPERATIVE EVALUATION; SALIVARY GLAND TUMOR; SKIN TUMOR; SPINDLE CELL; SQUAMOUS CELL; SYNOVIAL SARCOMA; TERATOMA; THYMOMA; TUMOR BIOPSY; TUMOR CLASSIFICATION; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR VOLUME;

ADULT; AGED; CHORISTOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HAMARTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, GERM CELL AND EMBRYONAL; RETROSPECTIVE STUDIES; THYMOMA; THYMUS NEOPLASMS;

EID: 5044227782     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000135518.27224.3f     Document Type: Article

References (43)

1. Armour A, Williamson JMS. Ectopic cervical hamartomatous thymoma showing extensive myoid differentiation. J Laryngol Otol. 1993;107: 155-158.
2. Chan JKC, Rosai J. Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol. 1991;22: 349-367.
3. Chu PG, Lyda MH, Weiss LM. Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumors. Histopathology. 2001;39:9-16.
4. Chu PG, Weiss LM. Keratin expression in human tissues and neoplasms. Histopathohgy. 2002;40:403-439.
5. Chu PG, Weiss LM. Expression of cytokeratin 5/6 in epithelial neoplasms: an immunohistochemical study of 509 cases. Mod Pathol. 2002; 15:6-10.
6. Dardick I, Stratis M, Parks WR, et al. S-100 protein antibodies do not label normal salivary gland myoepithelium. Am J Pathol. 1991;138:619-628.
7. Demirkesen C, Hoede N, Moll R. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J Cutan Pathol. 1995;22:518-535.
8. Doctor VM, Simba MR. Ectopic hamartomatous thymoma: a case report and review of the literature. Int J Cancer. 1993;30:192-195.
9. Eulderink F, de Graaf P. Ectopic hamartomatous thymoma located presternally. Eur J Surg. 1998;164:629-630.
10. Fetsch JF, Weiss SW. Ectopic hamartomatous thymoma: clinicopathologic, immunohistochemical, and histogenetic considerations in four new cases. Hum Pathol. 1990;21:662-668.
11. Franke WW, Schmid E, Schiller DL, et al. Differentiation-related patterns of expression of proteins of intermediate-sized filaments in tissues and cultured cells. Cold Spring Harb Symp Quant Biol. 1982;46:431-453.
12. Frazer JE. The disappearance of the precervical sinus. J Anat. 1926;61: 132-143.
13. Fukunaga M. Ectopic hamartomatous thymoma: a case report with immunohistochemical and ultrastructural studies. APMIS. 2002;110:565-570.
14. Garrett FD. Development of the cervical vesicles in man. Anat Rec. 1948; 100:101-113.
15. Gusterson BA, Monaghan P, Mahendran R, et al. Identification of myoepithelial cells in human and rat breasts by anti-common acute lymphoblastic leukemia antigen antibody A12. J Natl Cancer Inst. 1986;77:343-349.
16. Henderson CJA, Gupta L. Ectopic hamartomatous thymoma: a case study and review of the literature. Pathology. 2000;32:142-146.
17. Hirokawa M, Tadaoka Y, Shimizu M, et al. Ectopic hamartomatous thymoma: report of a case with fine needle aspiration biopsy findings. Acta Cytol. 1999;43:232-234.
18. Jernstrom P, Prietto CA. Accessory parotid gland tissue at base of neck. Arch Pathol. 1962;73:53-60.
19. Lee SN, Cho MS, Koo H, et al. Ectopic hamartomatous thymoma: a case report showing CD99+ lymphocytes and a low proliferative index. Arch Pathol Lab Med. 2003;127:e378-e381.
20. Mahendran R, McIlhinney R, O'Hare M, et al. Expression of the common acute lymphoblastic leukaemia antigen (CALLA) in the human breast. Mol Cell Probes. 1989;3:39-44.
21. Marschall J, Kanthan R. The sarcomatous guise of cervical ectopic hamartomatous thymoma. Head Neck. 2002;24:800-804.
22. Mentzel T, Kriegsmann J, Kosmehl H, et al. Ektopisches hamartomatöses Thymom: Fallbericht mit Besonderer berücksichtigung der Differential-diagnose. Pathologe. 1995;16:359-363.
23. Michal M, Neubauer L. Carcinoma arising in ectopic hamartomatous thymoma: a previously unpublished occurrence. Report of two cases. Zentralbl Pathol. 1993;139:381-386.
24. Michal M, Neubauer L, Fakan F. Carcinoma arising in ectopic hamartomatous thymoma: an ultrastructural study. Pathol Res Pract. 1996;192: 610-618.
25. Michal M, Zámečnik M, Gogora M, et al. Pitfalls in the diagnosis of ectopic hamartomatous thymoma. Histopathology. 1996;29:549-555.
26. Michal M, Mukensnabl R. Clear cell epithelial cords in an ectopic hamartomatous thymoma [Letter]. Histopathology. 1999;35:89-90.
27. Miettinen M. Keratin immunohistochemistry: update of applications and pitfalls. Pathol Annu. 1993;28:113-143.
28. Moll R, Franke WW, Schiller DL, et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 1982;31:11-24.
29. Moll R, Moll I, Wiest W. Changes in the pattern of cytokeratin polypeptides in epidermis and hair follicles during skin development in human fetuses. Differentiation. 1982;23:170-178.
30. Moore KL. The branchial apparatus and the head and neck. In: The Developing Human: Clinically Oriented Embryology, 4th ed, chapter 10. Philadelphia, Saunders, 1988:170-206.
31. Moritani S, Kushima R, Sugihara H, et al. Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections. Mod Pathol. 2002;15:397-405.
32. Ogawa Y, Toyosawa S, Ishida T. Keratin 14 immunoreactive cells in pleomorphic adenomas and adenoid cystic carcinomas of salivary glands. Virchows Arch. 2000;437:58-68.
33. Rosai J, Levine GD, Limas C. Spindle cell thymic anlage tumor: four cases of a previously undescribed benign neoplasm of the lower neck. Lab Invest. 1982;46:70A.
34. Rosai J, Limas C, Husband EM. Ectopic hamartomatous thymoma: a distinctive benign lesion of the lower neck. Am J Surg Pathol. 1984;8:501-513.
35. Roth JA, Enzinger FM, Tannenbaum M. Synovial sarcoma of the neck: a follow-up study of 24 cases. Cancer. 1975;35:1243-1253.
36. Saeed IT, Fletcher CDM. Ectopic hamartomatous thymoma containing myoid cells. Histopathology. 1990;17:572-574.
37. Schaafsma HE, Ramaekers FCS. Cytokeratin subtyping in normal and neoplastic epithelium: basic principles and diagnostic applications. Pathol Annu. 1994;29:21-62.
38. Smedts F, Ramaekers F, Leube RE, et al. Expression of keratins 1, 6, 15, 16, and 20 in normal cervical epithelium, squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Am J Pathol. 1993;142: 403-412.
39. Smith PS, McClure J. Unusual subcutaneous mixed tumour exhibiting adipose, fibroblastic, and epithelial components. J Clin Pathol. 1982;35: 1074-1077.
40. Willis RA. Developmental vestiges and their pathology. In: The Borderland of Embryology and Pathology, 2nd ed, chapter 7. Washington, DC: Butterworth, 1962:259-314.
41. Wilson CP. Lateral cysts and fistulae of the neck of developmental origin. Ann R Coll Surg Engl. 1955;17:1-26.
42. Youngs LA, Scofield HH. Heterotopic salivary gland tissue in the lower neck. Arch Pathol. 1967;83:550-556.
43. Zhao C, Yamada T, Kuramochi S, et al. Two cases of ectopic hamartomatous thymoma. Virchows Arch. 2000;437:643-647.