Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolon

Journal of Gastroenterology

Volumn 43, Issue 8, 2008, Pages 626-631

  Adachi, Yasushi ^a,b   Ishii, Yoshifumi ^a   Yoshimoto, Mitsuru ^c   Yoshida, Yukinari ^d   Endo, Takao ^a   Yamamoto, Hiroyuki ^b   Akashi, Hirofumi ^b   Imai, Kohzoh ^b   Shinomura, Yasuhisa ^b   Kato, Yasuo ^a  

^a Sapporo Shirakabadai Hospital   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c Tenshi Hospital   (Japan)

^d Doto Hospital   (Japan)

Author keywords

c kit; CD34; Interstitial cell of Cajal (ICC); Sigmoid megacolon

Indexed keywords

CD34 ANTIBODY; PROTEIN ANTIBODY; PROTEIN S 100; STEM CELL FACTOR;

ABDOMINAL RADIOGRAPHY; ADULT; AGED; ARTICLE; CASE REPORT; CELL POPULATION; COLON RESECTION; COLONOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HIRSCHSPRUNG DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CELL OF CAJAL; INTESTINE INNERVATION; LABORATORY TEST; MALE; NEUROMUSCULAR DISEASE; PHENOTYPE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

AGED; ANTIGENS, CD34; COLONOSCOPY; DIAGNOSIS, DIFFERENTIAL; ENTERIC NERVOUS SYSTEM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEGACOLON; MIDDLE AGED; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-KIT; SIGMOID DISEASES;

EID: 50349094981     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2207-4     Document Type: Article

References (27)

1. Hagger R, Finlayson C, Jeffrey I, Kumar D. Role of the interstitial cells of Cajal in the control of gut motility. Br J Surg 1997;84:445-450.
2. Yamataka A, Kato Y, Tibboel D, Murata Y, Sueyoshi N, Fujimoto T, et al. A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease. J Pediatr Surg 1995;30:441-444.
3. Vanderwinden JM, Rumessen JJ, Liu H, Descamps D, De Laet MH, Vanderhaeghen JJ. Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Gastroenterology 1996;111:901-910.
4. + cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 1997;92:332-334.
5. Streutker CJ, Huizinga JD, Campbell F, Ho J, Riddell RH. Loss of CD117 (c-kit)-and CD34-positive ICC and associated CD34-positive fibroblasts defines a subpopulation of chronic intestinal pseudo-obstruction. Am J Surg Pathol 2003;27:228-235.
6. He CL, Burgart L, Wang L, Pemberton J, Young-Fadok T, Szurszewski J, et al. Decreased interstitial cell of Cajal volume in patients with slow-transit constipation. Gastroenterology 2000;118:14-21.
7. Wedel T, Spiegler J, Soellner S, Roblick UJ, Schiedeck TH, Bruch HP, et al. Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. Gastroenterology 2002;123:1459-1467.
8. Lyford GL, He CL, Soffer E, Hull TL, Strong SA, Senagore AJ, et al. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 2002;51:496-501.
9. Lee JI, Park H, Kamm MA, Talbot IC. Decreased density of interstitial cells of Cajal and neuronal cells in patients with slowtransit constipation and acquired megacolon. J Gastroenterol Hepatol 2005;20:1292-1298.
10. He CL, Soffer EE, Ferris CD, Walsh RM, Szurszewski JH, Farrugia G. Loss of interstitial cells of Cajal and inhibitory innervation in insulin-dependent diabetes. Gastroenterology 2001;121:427-434.
11. Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, et al. A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol 2006;41:1076-1087.
12. Faussone-Pellegrini MS, Fociani P, Buffa R, Basilisco G. Loss of interstitial cells and a fibromuscular layer on the luminal side of the colonic circular muscle presenting as megacolon in an adult patient. Gut 1999;45:775-779.
13. Meier-Ruge WA, Muller-Lobeck H, Stoss F, Bruder E. The pathogenesis of idiopathic megacolon. Eur J Gastroenterol Hepatol 2006;18:1209-1215.
14. Iantorno G, Bassotti G, Kogan Z, Lumi CM, Cabanne AM, Fisogni S, et al. The enteric nervous system in Chagasic and idiopathic megacolon. Am J Surg Pathol 2007;31:460-468.
15. Robinson TL, Sircar K, Hewlett BR, Chorneyko K, Riddell RH, Huizinga JD. Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal. Am J Pathol 2000;156:1157-1163.
16. Hagger R, Gharaie S, Finlayson C, Kumar D. Regional and transmural density of interstitial cells of Cajal in human colon and rectum. Am J Physiol 1998;275:G1309-G1316.
17. Ward SM, Sanders KM. Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol Gastrointest Liver Physiol 2001;281:G602-G611.
18. Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 1994;480:91-97.
19. Torihashi S, Ward SM, Nishikawa S, Nishi K, Kobayashi S, Sanders KM. c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 1995;280:97-111.
20. Young HM, Torihashi S, Ciampoli D, Sanders KM. Identification of neurons that express stem cell factor in the mouse small intestine. Gastroenterology 1998;115:898-908.
21. Torihashi S, Nishi K, Tokutomi Y, Nishi T, Ward S, Sanders KM. Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype. Gastroenterology 1999;117:140-148.
22. Maeda H, Yamagata A, Nishikawa S, Yoshinaga K, Kobayashi S, Nishi K. Requirement of c-kit for development of intestinal pacemaker system. Development (Camb) 1992;116:369-375.
23. Wang XY, Berezin I, Mikkelsen HB, Der T, Bercik P, Collins SM, et al. Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistry. Am J Pathol 2002;160:1529-1540.
24. Liu LW, Thuneberg L, Huizinga JD. Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves. Am J Physiol 1994;266:G485-G496.
25. Gladman MA, Scott SM, Lunniss PJ, Williams NS. Systematic review of surgical options for idiopathic megarectum and megacolon. Ann Surg 2005;241:562-574.
26. Chang IY, Glasgow NJ, Takayama I, Horiguchi K, Sanders KM, Ward SM. Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction. J Physiol 2001;536:555-568.
27. Sanders KM, Ward SM. Interstitial cells of Cajal: A new perspective on smooth muscle function. J Physiol 2006;576: 721-726.