Does homocysteine-lowering treatment improve cardiovascular outcomes in patients with acute coronary syndromes?. What we have learned from clinical trials?

International Journal of Cardiology

Volumn 129, Issue 2, 2008, Pages 274-275

  Celik, Turgay ^a   Iyisoy, Atila ^a   Bugan, Baris ^a   Yuksel, U Cagdas ^b   Isik, Ersoy ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b Sarikamis Army District Hospital Turkey   (Turkey)

Author keywords

Acute coronary syndromes; Cardiovascular mortality; Homocysteine lowering treatment

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; FIBRINOGEN; FOLIC ACID; HOMOCYSTEINE; METHIONINE; MYOGLOBIN; PLACEBO; PYRIDOXINE; TROPONIN I;

ACUTE CORONARY SYNDROME; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CLINICAL TRIAL; ENDOTHELIAL DYSFUNCTION; HEART INFARCTION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; LOADING DRUG DOSE; NECROSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN METABOLISM; STROKE; THROMBOSIS; TREATMENT DURATION; TREATMENT RESPONSE;

ACUTE CORONARY SYNDROME; CLINICAL TRIALS AS TOPIC; EVIDENCE-BASED MEDICINE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; PROGNOSIS; RISK ASSESSMENT; TREATMENT OUTCOME;

EID: 50349091858     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.06.044     Document Type: Article

References (9)

1. Martin-Herrero F., Martin-Moreiras J., Pabon P., et al. Homocysteine and outcome in young patients with acute coronary syndromes. Int J Cardiol 118 (2007) 183-188
2. Merritt J.C., and Foody J.M. Nonlipid cardiovascular risk factors. In: Griffin B.P., and Topol E.J. (Eds). Manual of Cardiovascular Medicine. 2nd ed (2004), Lippincott Williams & Wilkins Company 550-553
3. Rosenson R.S., and Kang D.S. Overview of homocysteine. In: Rose B.D. (Ed). UpToDate (2006), UpToDate, Wellesley
4. Facila L., Nunez J.E., G. V.B., et al. Early determination of homocysteine levels in acute coronary syndromes, is it an independent prognostic factor?. Int J Cardiol 100 (2005) 275-279
5. Stubbs P.J., Al-Obaidi M.K., Conroy R.M., Collinson P.O., Graham I.M., and Noble I.M. Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes. Circulation 102 (2000) 605-610
6. Omland T., Samuelsson A., Hartford M., et al. Serum homocysteine concentration as an indicator of survival in patients with acute coronary syndromes. Arch Intern Med 160 (2000) 1834-1840
7. Matetzky S., Freimark D., Ben-Ami S., et al. Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction. Arch Intern Med 163 (2003) 1933-1937
8. Bodi V., Sanchis J., Llacer A., et al. Multimarker risk strategy for predicting 1-month and 1-year major events in non-ST-elevation acute coronary syndromes. Am Heart J 149 (2005) 268-274
9. Bonaa K.H., Njolstad I., Ueland P.M., et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354 (2006) 1578