EGFR mutant lung adenocarcinomas in patients with germline BRCA mutations

Journal of Thoracic Oncology

Volumn 3, Issue 7, 2008, Pages 805-

  Marks, Jenifer L ^a   Golas, Ben ^a   Kirchoff, Tomas ^a   Miller, Vincent A ^a   Riely, Gregory J ^a   Offit, Kenneth ^a   Pao, William ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BRCA2 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADULT; AMINO ACID SUBSTITUTION; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CASE REPORT; DISEASE SEVERITY; EXON; FRAMESHIFT MUTATION; GENETIC ASSOCIATION; HEREDITY; HUMAN; LETTER; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL CARCINOMA; LUNG CANCER; LUNG METASTASIS; MALE; ONCOGENE; OVARY CANCER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SMOKING; SOMATIC MUTATION; TUMOR LOCALIZATION; ADENOCARCINOMA; AGED; BREAST TUMOR; GENETICS; LUNG TUMOR; METASTASIS; MIDDLE AGED; MUTATION; PEDIGREE; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AGED; BREAST NEOPLASMS; FRAMESHIFT MUTATION; GENES, BRCA2; GERM-LINE MUTATION; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PEDIGREE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 50349088410     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31817e4664     Document Type: Letter

References (2)

1. Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004;101: 13306-13311.
2. Ludwig T, Fisher P, Ganesan S, et al. Tumor-igenesis in mice carrying a truncating Brca1 mutation. Genes Dev 2001;15:1188-1193.