Gene expression profiles of vascular smooth muscle show differential expression of mitogen-activated protein kinase pathways during captopril therapy of heart failure

Journal of Vascular Research

Volumn 45, Issue 5, 2008, Pages 445-454

  Chen, Frank C ^a   Brozovich, Frank V ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin; Myosin light chain phosphatase; Myosin targeting subunit of myosin light chain phosphatase (MYPT1); Nitric oxide; Vasoconstriction

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; CAPTOPRIL; COMPLEMENTARY DNA; CYTOCHROME C OXIDASE; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; NITRIC OXIDE; PALMITOYL COENZYME A HYDROLASE; PLACEBO; PRAZOSIN; RNA; SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD VESSEL TONE; CONGESTIVE HEART FAILURE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; ANIMAL; DISEASE MODEL; DNA MICROARRAY; DOWN REGULATION; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; HEART FAILURE; METABOLISM; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; AORTA; CAPTOPRIL; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART FAILURE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL INFARCTION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PORTAL VEIN; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 50349084414     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000126735     Document Type: Article

References (28)

1. Mehta PK, Griendling KK: Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol 2007;292:C82-C97.
2. Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Suzuki Y, Mezzano S, Plaza JJ, Egido J: Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension 2001;38:1382-1387.
3. Sekiguchi K, Li X, Coker M, Flesch M, Barger PM, Sivasubramanian N, Mann DL: Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure. Cardiovasc Res 2004;63:433-442.
4. Berk BC, Corson MA: Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res 1997;80:607-616.
5. Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM: Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation 2004;109:1196-1205.
6. Lyle AN, Griendling KK: Modulation of vascular smooth muscle signaling by reactive oxygen species. Physiology (Bethesda) 2006;21:269-280.
7. Dzau VJ: Theodore Cooper Lecture: tissue angiotensin and pathobiology of vascular disease - a unifying hypothesis. Hypertension 2001;37:1047-1052.
8. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW: Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994;74:1141-1148.
9. Griendling KK, Sorescu D, Lassegue B, Ushio-Fukai M: Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 2000;20:2175-2183.
10. Chen FC, Ogut O, Rhee AY, Hoit BD, Brozovich FV: Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation. J Mol Cell Cardiol 2006;41:488-495.
11. Karim SM, Rhee AY, Given AM, Faulx MD, Hoit BD, Brozovich FV: Vascular reactivity in heart failure: role of myosin light chain phosphatase. Circ Res 2004;95:612-618.
12. Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Wheeler DL: GenBank. Nucleic Acids Res 2007;35:D21-D25.
13. Boguski MS, Lowe TM, Tolstoshev CM: dbEST - database for 'expressed sequence tags'. Nat Genet 1993;4:332-333.
14. Wheeler DL, Church DM, Federhen S, Lash AE, Madden TL, Pontius JU, Schuler GD, Schriml LM, Sequeira E, Tatusova TA, Wagner L: Database resources of the National Center for Biotechnology. Nucleic Acids Res 2003;31:28-33.
15. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera RA, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, et al: Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 2004;428:493-521.
16. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
17. Pfeffer JM, Pfeffer MA, Braunwald E: Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res 1985;57:84-95.
18. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC, et al: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement trial. The SAVE Investigators. N Engl J Med 1992;327:669-677.
19. Jessup M, Brozena S: Heart failure. N Engl J Med 2003;348:2007-2018.
20. Konstam MA: Improving clinical outcomes with drug treatment in heart failure: what have trials taught? Am J Cardiol 2003;91:9-14.
21. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:145-153.
22. Chuaqui RF, Bonner RF, Best CJ, Gillespie JW, Flaig MJ, Hewitt SM, Phillips JL, Krizman DB, Tangrea MA, Ahram M, Linehan WM, Knezevic V, Emmert-Buck MR: Post-analysis follow-up and validation of microarray experiments. Nat Genet 2002;32(suppl):509-514.
23. Morey JS, Ryan JC, Van Dolah FM: Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biol Proced Online 2006;8:175-193.
24. Zheng B, Berrie CP, Corda D, Farquhar MG: GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Proc Natl Acad Sci USA 2003;100:1745-1750.
25. Zheng B, Chen D, Farquhar MG: MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Proc Natl Acad Sci USA 2000;97:3999-4004.
26. Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem 2003;278:22278-22283.
27. Culjkovic B, Topisirovic I, Borden KL: Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. Cell Cycle 2007;6:65-69.
28. Geng Y, Valbracht J, Lotz M: Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 1996;98:2425-2430.