The tight junction proteins ZO-1, occludin and actin participate in the permeability increasing of blood-brain barrier induced by hypoxia-ischemia

Chinese Journal of Contemporary Pediatrics

Volumn 10, Issue 4, 2008, Pages 513-516

  Wu, Li Wen ^a   Yin, Fei ^a   Peng, Jing ^a   Wang, Wei Dong ^a   Gan, Na ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Actin; Blood brain barrier; Culture; Occludin; Permeability; Tight junction protein; ZO 1

Indexed keywords

ACTIN; BOVINE SERUM ALBUMIN; CELL PROTEIN; IODINE 125; OCCLUDIN; PROTEIN ZO1; TIGHT JUNCTION PROTEIN;

ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL JUNCTION; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOXIA; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; ISCHEMIA; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; RAT; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ACTINS; ANIMALS; ANOXIA; BLOOD-BRAIN BARRIER; FEMALE; ISCHEMIA; MALE; MEMBRANE PROTEINS; PERMEABILITY; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS;

EID: 50249174381     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Chinese source.
2. Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, et al. Rho-mediated regulation of tight junction during monocyte migration across blood-brain barrier in HIV-1 encephalitis (HIVE) [J]. Blood, 2006, 107 (12): 4770-4880.
3. González-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins [J]. Prog Biophys Mol Biol, 2003, 81 (1): 1-44.
4. Ng I, Yap E, Tan WL, Kong NY. Blood-brain barrier disruption following traumatic brain injury: roles of tight junction proteins [J]. Ann Acad Med Singapore, 2003, 32 (5 Suppl): 63-66.
5. Kis B, Snipes JA, Deli MA, Abrahám CS, Yamashita H, Ueta Y, et al. Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins[J]. Acta Neurochir Suppl, 2003, 86: 565-568.
6. McCarthy KD, Vellis JD. Preparation of separate astroglial and oligdendroglial cell cultures from rat cerebral tissue[J]. J Cell Biol, 1980, 85 (3): 890-902.
7. Chinese source.
8. Chinese source.
9. Nusrat A, Parkos CA, Verkade P, Foley CS, Liang TW, Innis-Whitehouse W, et al. Tight junctions are membrane microdomains [M]. J Cell Sci, 2000, 113 (Pt 10): 1771-1778.
10. Brown RC, Thomas P. Hypoxia/aglycemia altersexpression of occludin and actin in brain endothelial cells [J]. Biochem Biophy Res, 2005, 327 (4): 1114-1123.
11. Hartwig W, Andrea L. Tight junctions of the blood-brain barrier: development, composition and regulation[J]. Vascul Pharmacol, 2002, 38 (6): 323-337.
12. Kago T, Takagi N, Date I, Takenaga Y, Takagi K, Takeo S. Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries[J]. Biochem Biophys Res Common, 2006, 339 (4): 1197-1203.
13. Mark WM, Margaret MW, Eugene BC. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption[J]. Am J Physiol Gastrointest Liver Physiol, 2006, 290 (2): 222-231.