Cerebral infarction in a patient with macrothrombocytopenia with leukocyte inclusions (MTCP, May-Hegglin anomaly/Sebastian syndrome)

Journal of Nippon Medical School

Volumn 75, Issue 4, 2008, Pages 228-232

  Nishiyama, Yutaka ^a   Akaishi, Junko ^a   Katsumata, Toshiya ^a   Katsura, Ken Ichiro ^a   Katayama, Yasuo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Cerebral infarction; Macrothrombocytopeia; May Hegglin anomaly

Indexed keywords

ANTIHYPERTENSIVE AGENT; GLYCERIN FRUCTOSE; GLYCEROL DERIVATIVE; NORPHENAZONE;

AGED; ANAMNESIS; APHASIA; ARTICLE; ATHEROSCLEROSIS; BLEEDING TIME; BLOOD EXAMINATION; BLOOD SMEAR; BRAIN INFARCTION; CAROTID ARTERY; CASE REPORT; CAUDATE NUCLEUS; CELL INCLUSION; COMPUTER ASSISTED TOMOGRAPHY; CONSCIOUSNESS DISORDER; ECHOGRAPHY; FAMILY HISTORY; FEMALE; FRONTAL LOBE; GENE MUTATION; GENETIC ANALYSIS; HEART ATRIUM FIBRILLATION; HEMIPARESIS; HEMIPLEGIA; HOSPITAL ADMISSION; HUMAN; HYPERTENSION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; JAPANESE; LABORATORY TEST; LEUKOCYTE; LEUKOCYTE DISORDER; MACROTHROMBOCYTOPENIA WITH LEUKOCYTE INCLUSION; MAY HEGGLIN ANOMALY; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; POINT MUTATION; SEBASTIAN SYNDROME; TEMPORAL LOBE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TRANSTHORACIC ECHOCARDIOGRAPHY;

AGED; BLOOD PLATELETS; CEREBRAL INFARCTION; FEMALE; HUMANS; INCLUSION BODIES; LEUKOCYTES; MOLECULAR MOTOR PROTEINS; MUTATION; MYOSIN HEAVY CHAINS; SYNDROME; THROMBOCYTOPENIA;

EID: 50249160612     PISSN: 13454676     EISSN: 13473409     Source Type: Journal    
DOI: 10.1272/jnms.75.228     Document Type: Article

References (10)

1. Greinacher A, Mueller-Eckhardt C: Hereditary types of thrombocytopenia with giant platelets and inclusion bodies in the leukocytes. Blut 1990; 60: 53-60.
2. Peterson LC, Rao KV, Crosson JT, et al.: Fetcher syndrome-A variant of Alport's syndrome with leukocyte inclusions and macrothrombocytepenia. Blood 1985; 65: 397-400.
3. Kunishima S, Kojima T, Matsushita T, et al.: Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytepenia with leukocyte inclusions ( May-Hegglin anomaly / Sebastian syndrome). Blood 2001; 97: 1147-1149.
4. Kunishima S, Matsushita T, Kojima T, et al.: Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH-9 disorders: Association of subcellar localization with MYH-9 mutations. Lab Invest 2003; 83: 115-122.
5. Coller BS, Zarrabi MH: Platelet membrane studies in the May-Hegglin anomaly. Blood 1981; 5: 279-284.
6. The Antiphospholipid Antibodies in Stroke study (APASS) Group: Anticardiolipin antibodies are an dependent risk factor for first ischemic stroke. Neurology 1993; 43: 2069-2073.
7. Tuhrim S, Rando DH, Wu XX, et al.: Elevated anticardiolipin antibody titer is a stroke risk factor in multiethnic population independent of isotype or degree of positivity. Stroke 1999; 30: 1561-1565.
8. Lim W, Crowther MA, Eikelboom JW: Management of antiphospholipid antibody syndrome. JAMA 2006; 295: 1050-1057.
9. McDunn S, Hartz W, Tsao C, et al.: Coronary thrombosis in a patient with May-Hegglin anomaly. Am J Clin Pathol 1991; 95: 715-718.
10. Goto S, Kasahara H, Sakai H, et al.: Functional compensation of the low platelet count by increased individual platelet size in a patient with May-Hegglin anomaly presenting with acute infarction. Int J Cardiol 1998; 64: 171-177.